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Volume 17, Issue 1
Displaying 1-14 of 14 articles from this issue
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Keishi ABE, Seiji MIYAZAKI, Takashi KUSAKA, Nobuo IROKAWA, Haruki AOYA ...1976 Volume 17 Issue 1 Pages 1-11
Published: 1976
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSPlasma renin activity (PRA) was measured in 38 cases of aortitis syndrome. The values of resting peripheral vein blood PRA were 32.2±4.2 (SE) mμg/ml. These values were 3 times higher than those of normal subjects. Hypertension due to renal arterial stenosis was observed in 18 cases. Their resting PRA values were 41.2±6.0mμg/ml, while in the remaining 20 patients without renovascular hypertension those values were 24.2±5.4mμg/ml.
The patients belonging to aortic arch type or extensive type had 2 times higher PRA values than those of abdominal type. The patients with stenosis or obstruction of common carotid arteries had significantly higher PRA values than the patients without these lesions. Hyperresponse of renin secretion to upright posture was also observed in the same patients with carotid artery stenosis.
Abnormal renin release in Takayasu's arteritis disappeared after denervation of the carotid sinus nerve. The present study suggests that the unstable state of carotid sinus reflex is the main cause for the hypersecretion of renin.View full abstractDownload PDF (533K) -
The Effects of Autonomic Nervous Blocking and Anti-Thyroid Drug TreatmentToshiro FUNATSU1976 Volume 17 Issue 1 Pages 12-24
Published: 1976
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSThis work was intended to analyze the sympathetic and parasympathetic factors affecting the hemodynamics of hyperthyroidism.
Seven patients with hyperthyroidism, diagnosed based on the determinations of BMR, 131I-uptake, T3-resin sponge uptake (T3-RSU), and serum level of thyroxine (T4) were subjected to the study. The hemodynamic estimation was done (1) at rest, (2) after vagus blocking by the injection of 0.04mg/Kg b.wt. atropine and 0.2mg/Kg b.wt. propranolol before (hyperthyroid state=H) and after (euthyroid state=E) antithyroid drug therapy. Cardiac output was measured by the dye-dilution method, and the value was calculated according to the standard Hamilton formula.
The following results were obtained. (1) The vagal tone is lower in H than in E, on the other hand, sympathetic β-receptor tone is higher in H than in E. (2) The sympathetic α-receptor tone in H may be equivalent to that in E. (3) There might exist inotropic factors which affect the hemodynamics, other than autonomic nervous system in H.View full abstractDownload PDF (721K) -
Masaya SUGIURA, Shinichiro OHKAWA, Keisuke HIRAOKA, Iwao KUWAJIMA, Kei ...1976 Volume 17 Issue 1 Pages 25-31
Published: 1976
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSThe electrical axis of the heart in 1, 000 aged people more than 56 years of age was classified as normal axis in 58%, left axis deviation in 17.4%, mild left axis deviation in 21.9%, and right axis deviation in 2.7%.
Pathological examination disclosed that left axis deviation was associated with myocardial infarction in 20%, right bundle branch block in 16%, but showed no significant relationships with coronary sclerosis, myocardial fibrosis and cardiac hypertrophy. Right axis deviation was associated with right bundle branch block in 66.7% and right ventricular hypertrophy in 22.2%.View full abstractDownload PDF (403K) -
Taro ISHIYAMA, Yoshiharu MORITA, Seiichi TOYAMA, Toru YAMAGAMI, Nozomu ...1976 Volume 17 Issue 1 Pages 32-42
Published: 1976
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSExpecting activation of myocardial energy liberation, coenzyme Q was applied as a treatment to 55 patients suffering from congestive heart failure. Daily doses of 50 to 100mg of coenzyme Q7 were injected intravenously in 21 cases for 3 to 35 days. Daily doses of 60mg of coenzyme Q7 were administered perorally in 17 cases for 14 to 196 days. Daily doses of 30mg of coenzyme Q10 were administered perorally in 17 cases for 7 to 182 days. Clinical effects were evaluated within 4 weeks by the criteria using a scoring method of severity of congestive heart failure which was devised by the authors. In summary a certain effect was found in 20 cases and a mild effect was observed in 29 cases. No significant changes were observed in heart rate and blood pressure. Exanthema appeared in 2 patients of the group of coenzyme Q7 intravenous injection. In conclusion the therapeutic effect of coenzyme Q was thought to be mild but stable in supplement to digitalis therapy in cases of congestive heart failure.View full abstractDownload PDF (550K) -
Naoto HANAZONO, Hiromu ODA, Hisaichi ISHIDA, Tadashi HATA, Yoshio KATS ...1976 Volume 17 Issue 1 Pages 43-53
Published: 1976
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSFour cases of variant angina pectoris with normal findings on coronary arteriogram were experienced. The facts may show that the existence of serious arteriosclerotic lesions in a major branch of coronary artery as pointed out by Prinzmetal is at least not essential for the occurrence of anginal attack in the present disease. But the finding that age and sex distribution of variant angina was nearly the same as that of effort angina seems to still indicate the possibility that arteriosclerotic lesion somehow participates in the mechanism of occurrence of the present disease.View full abstractDownload PDF (4748K) -
Jami G. SHAKIBI, Iraj ARYANPUR, Mansoureh PAYDAR, Fatemeh REYHANI, Bij ...1976 Volume 17 Issue 1 Pages 54-60
Published: 1976
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSOuabain-induced tachyarrhythmias in cats can be abolished by bolus injection of NaHCO3 solution. This effect is consistent, rapid and of short duration. The antiarrhythmic effect appears to be due to high sodium concentration of this solution, as hypertonic NaCl solution with equal concentration of sodium exerts the same effect. Alkalinity and hyper-osmolality cannot account for the antiarrhythmic effect of NaHCO3 as respiratory alkalosis and mannitol solution with equal osmolality did not relieve the arrhythmias. Overdrive suppression is not responsible for this effect as the heart rate slows down during normalization of the cardiac rhythm. It is postulated that high Na+ concentration abolished ouabain-induced arrhythmias by competition with calcium ion in the myocardial cell sarcotubular system thus replacing it. This hypothesis is supported by the known effect of other agents such as sodium-EDTA and magnesium chloride, in digitalis-induced arrhythmias, which exert their antiarrhythmic properties by removal or displacement of calcium in the myocardial cells.View full abstractDownload PDF (1626K) -
I. An Increase of Plasma Renin Activity Associated with Increased Permeability of Retinal Vessels and AngionecrosisToyoaki OKABAYASHI, Motoomi NAKAMURA, Akinobu SUMIYOSHI, Yoshisuke OKA ...1976 Volume 17 Issue 1 Pages 61-72
Published: 1976
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSThe renal parenchyma of 5 crub-eating monkeys (Macaca irus) was wrapped by cellophane and plasma renin activity, blocd pressure and vascular permeability of ocular ground were measured in comparison with 5 unoperated control monkeys. The results demonstrated that increases of systolic arterial pressure, plasma renin activity, and permeability of the retinal vessels were found in 4 operated monkeys. There was no such abnormal finding in the unoperated control monkeys. Generally there was a rough parallelism among levels of plasma renin activity and systolic blood pressure, an increase of permeability of retinal vessels and fibrinoid angionecrosis and/or necrotizing angitis similar to polyarteritis nodosa.View full abstractDownload PDF (2159K) -
Shigetoshi CHIBA1976 Volume 17 Issue 1 Pages 73-79
Published: 1976
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSThe right atrium isolated from the dog heart was perfused through the cannulated sinus node artery with heparinized arterial blood led from a support dog anesthetized with 30mg/Kg of sodium pentobarbital. When adenosine was administered into the sinus node artery, negative chronotropic and inotropic effects were dose-relatedly induced. The threshold dose for inducing the negative ones was 0.3μg. Even a large dose level of 100μg of adenosine did not cause sinus arrest although a profound sinus deceleration was induced. Adenosine action was suppressed by treatment with caffeine both in chronotropism and in inotropism. On the other hand, ACh induced only negative inotropic effect at a dose range of 0.01-0.03μg. At 0.1μg, ACh produced a significantly negative chronotropic effect. A large amount of 3-10μg of ACh usually caused sinus arrest. Atropine treatment inhibited a negative chronotropic effect much more readily than a negative inotropic one. Although ACh action was enhanced by physostigmine, the difference of threshold doses remained unchanged even after physostigmine treatment.
From these results, either adenosine or ACh depresses both SA nodal pacemaker activity and atrial contractile force and there may be the difference of receptor density for ACh between the SA node and atrial tissue.View full abstractDownload PDF (318K) -
Juro IRIUCHIJIMA, Yoshinobu NUMAO, Hiroyuki SUGA1976 Volume 17 Issue 1 Pages 80-87
Published: 1976
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSCardiac output was measured by a pulse contour method in renovascular hypertensive rats, deoxycorticosterone (DOC) hypertensive rats and normotensive control Wistar rats in the conscious state. All rats were male in sex and 12-13 weeks of age (2-3 weeks after operation in the hypertensive rats). Cardiac output per body weight was not significantly different among the groups. Therefore, the hypertension in the experimentally hypertensive rats in the conscious state was ascribable to an increased total peripheral resistance. After anesthesia with pentobarbital and thoracotomy, the DOC rats were no longer hypertensive. However, in the renovascular hypertensive rats, the hypertensive state due to an increase in vascular resistance persisted after anesthesia, thoracotomy, and even ganglion blockade with hexamethonium bromide, indicating the importance of non-neural factors in the renovascular hypertension. Aortic compliance measured in vivo under anesthesia was smaller in either the renovascular or DOC hypertensive rats than in the control rats before and after ganglion blockade, which suggests a non-neural hardening of elastic vessels in the experimental hypertensions.View full abstractDownload PDF (479K) -
Akira FURUSE, Hiroshi INOUE, Akira MIZUNO, Masahiro SAIGUSA1976 Volume 17 Issue 1 Pages 88-96
Published: 1976
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSThe effects of allopurinol on the myocardial oxygen metabolism were studied in dogs with acute coronary artery occlusion. Upon occlusion of the contributory branch of the coronary artery, myocardial pO2, as measured with an improved polarographic technique, decreased to various lower values depending on the site of the electrode inserted. In the slightly ischemic myocardium, where myocardial pO2 decreased less than 50% of the control by the coronary occlusion, administration of allopurinol brought about a further diminution in myocardial pO2. In the severely ischemic myocardium, where myocardial pO2 decreased more than 50% of the control upon the coronary occlusion, no significant change was observed following allopurinol infusion. Theoretical beneficial effects of allopurinol on the ischemic myocardium by preserving functional purine bases might be offset by the aggravation of the negative oxygen balance in the ischemic but still viable myocardium following administration of allopurinol.View full abstractDownload PDF (495K) -
David GRANDISON, Robert S. SHEPARD, Raymond L. HENRY1976 Volume 17 Issue 1 Pages 97-105
Published: 1976
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSPyridinolcarbamate (PDC) was injected at a dose of 10mg/Kg of body weight into the femoral vein of anesthetized dogs with a bilateral cervical vagosympathotomy. At this dose, it produced a transitory decrease in systolic, diastolic, and mean arterial pressure and an increase in heart rate. In addition, it produced a more prolonged increase in stroke volume, peak aortic flow, cardiac output, and left ventricular minute work. It also lowered peripheral resistance and apparently decreased the vasoconstrictor action of injected norepinephrine (1μg of active base/Kg of body weight). These data are consistent with the view that PDC has a direct action on the heart that is similar to that of norepinephrine and that PDC blocks the alpha adrenergic receptors of the systemic resistance vessels.View full abstractDownload PDF (1626K) -
Hitonobu TOMOIKE, Kenji KAWAGUCHI, Akira TAKESHITA, Tuneo HIRATA, Moto ...1976 Volume 17 Issue 1 Pages 106-113
Published: 1976
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSAn abnormal echocardiographic signal was detected in the myocardium on the echocardiographic examination of the septum and posterior left ventricular wall in a patient found to have lymphosarcoma which was diffusely infiltrated in the myocardium. This echocardiographic abnormality was well correlated with the autopsy findings. Echocardiography appears to be one of useful methods in diagnosing cardiac mural tumor antemortemly.View full abstractDownload PDF (2423K) -
Yasunobu NONAKA, Masashi MORI, Yasuro SUGISHITA, Masao ISHII, Tadashi ...1976 Volume 17 Issue 1 Pages 114-122
Published: 1976
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSDyspnea, back pain, edema, and cyanosis developed suddenly in a 23-year-old woman during the last trimester of her first pregnancy. Although she had been noticed to have the enlarged heart and exertional shortness of breath to a slight degree, she had been apparently in good condition without any significant heart murmurs. Clinically, recurrent episodes of disseminated intravascular coagulation, including pulmonary thrombosis, were thought to be superimposed to Eisenmenger syndrome associated with toxemia of pregnancy. Anticoagulant and fibrinolytic treatments were tried, but their effectiveness was limited by hemorrhagic diathesis. She died of respiratory and circulatory failure after delivery of a moribund baby. Autopsy revealed Eisenmenger complex (a defect in the membranous portion of the interventricular septum and pulmonary vascular disease) and many fresh hemmorrhages in both lungs with a lot of new and organized thrombi. Fresh thrombi were also seen in the heart, the pancreas and the kidneys.
The high peripartal mortality in Eisenmenger syndrome could be attributed to pulmonary thrombosis, which may be related to DIC, as well as to peripartal changes in circulatory function.View full abstractDownload PDF (3099K) -
Satoshi OGAWA, Mitsuru KIMURA, Michio OKADA, Takanori OGINO, Kazuhiko ...1976 Volume 17 Issue 1 Pages 123-132
Published: 1976
Released on J-STAGE: December 09, 2008
JOURNAL FREE ACCESSA case of transient left posterior hemiblock and various intraventricular conduction disturbances associated with acute anterolateral infarction is reported. The earliest manifestation was an appearance of ventricular premature systoles originated in the area of the left posterior fascicle. On following recordings left posterior hemiblock with periods of high grade A-V block developed. A few minutes later regular alternation of left posterior hemiblock and left anterior hemiblock was recorded in the presence of 2:1 A-V block. The mechanism for such rare manifestation is analysed. After representing complete left bundle branch block, spontaneous recovery of normal conduction was obtained without any change in heart rate.View full abstractDownload PDF (2493K)
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