Journal of Japanese Society of Oral Oncology
Online ISSN : 1884-4995
Print ISSN : 0915-5988
ISSN-L : 0915-5988
Volume 35, Issue 1
Displaying 1-4 of 4 articles from this issue
  • Tomofumi Naruse, Kohei Furukawa, Keisuke Omori, Taro Miyoshi, Mitsunob ...
    2023 Volume 35 Issue 1 Pages 1-6
    Published: 2023
    Released on J-STAGE: March 22, 2023
    Metastasis to lymph nodes from oral squamous cell carcinoma (OSCC) without neck dissection classification (lingual lymph nodes (LLN) and lateral retropharyngeal lymph nodes (LRPN)) is rare and difficult to deal with. The aim of the present study was to assess the treatment modality and prognosis of LLN and LRPN in patients diagnosed with OSCC.
    This retrospective study involved a chart review of the clinical records of OSCC patients diagnosed with LLN or LRPN metastasis between June 2008 and March 2021. Data were collected and treatment outcomes were analyzed.
    Two OSCC patients with primary LRPN metastasis underwent LRPN dissection or superselective intra-arterial chemoradiotherapy. One patient with recurrent lateral LLN underwent surgery. Seven patients with recurrent LRPN and 7 patients with recurrent para-hypoid lymph nodes underwent chemoradiotherapy, bioradiotherapy, immune checkpoint inhibitors (ICIs) or best supportive care. The cumulative 1-year overall survival rate was 25.8% on LLN (especially para-hyoid lymph node), and 33.3% on LRPN.
    Cetuximab or ICIs are important to determine an effective treatment strategy for LLN or LRPN metastasis in the future.
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  • Taiki Suzuki, Satoru Ogane, Shigeo Yoshida, Chiho Hiraga, Junko Nakaji ...
    2023 Volume 35 Issue 1 Pages 7-15
    Published: 2023
    Released on J-STAGE: March 22, 2023
    Surgery for oral cancer that has extended to the midface region requires an approach to the site where blood vessels and nerves run intricately, and bleeding makes the operation more difficult. In addition, occlusal reconstruction and prosthesis fitting after extensive resection of a maxillary tumor are very difficult because an anchor for fixing the prosthetic device may not be possible. We report a case of giant carcinoma ex pleomorphic adenoma of the midface treated by a multidisciplinary approach involving airway management, nutrition management by gastrostomy, embolization, surgery and occlusal reconstruction.
    The patient was a 56-year-old man who presented with an extensive mass in the hard palate. He reported having been diagnosed with pleomorphic adenoma six years ago at another hospital, but stopped going to the hospital. We performed a biopsy of the mass in the hard palate at our institution, which was diagnosed as carcinoma ex pleomorphic adenoma. We discussed with relevant departments (e.g., otorhinolaryngology, radiology, ophthalmology, gastroenterology and anesthesiology) and planned endovascular embolization, tracheostomy and gastrostomy before surgery. Transcatheter maxillary artery embolization was effective for reducing blood loss for subtotal maxillectomy. Regarding postoperative occlusal reconstruction, although there were extensive maxillary defects, sharing of the preoperative treatment plan enabled early resumption of oral intake with an immediate surgical obturator. Two years have passed since the operation and there has been no recurrence.
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  • Yoshio Ueno, Tomoaki Imai, Atsuko Niki, Kayoko Amino, Nobuo Morita, Na ...
    2023 Volume 35 Issue 1 Pages 17-23
    Published: 2023
    Released on J-STAGE: March 22, 2023
    We report a case of esophageal carcinoma with oral metastasis with a review of the literature. A 68-year-old man diagnosed with esophageal carcinoma underwent radiation therapy at another hospital, went into remission, and was admitted to our department with a chief complaint of tongue discomfort. A 10-mm tumor was found in the tongue, and a systemic search revealed metastatic tongue malignancy. Partial tongue resection was performed because the growth of the tongue tumor was impairing quality of life (QOL). There was no recurrence until he died due to a deteriorated general condition. In Japan, there have been 16 previous reports of esophageal carcinoma metastasizing to the oral cavity. In the 17 patients including this case, the time from detecting primary lesion recurrence to the onset of oral metastasis was 3.1±2.2 months (mean±SD). Survival after oral metastasis was 5.7±4.2 months (jawbone: 6.8±4.9 months, oral soft tissue: 5.4±3.9 months); the time to primary esophageal lesion recurrence was 4.0±2.1 months in the recurrent group and 8.8±5.8 months in the non-recurrent group. Oral metastases were mostly found in the tongue, gingiva, and jawbone. Surgical resection for tongue tumors and chemotherapy or radiation therapy for gingival and jaw tumors were the treatment policies; these were selected to improve and maintain QOL at the end of life. Moreover, even in non-recurrent cases with good control of the primary esophageal lesion, if metastatic control is poor, the survival period is as short as that of recurrent cases. Thus, it is necessary to perform radical treatment actively where possible.
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  • Satoshi Fukuzawa, Kenji Yamagata, Kazuhiro Terada, Fumihiko Uchida, Na ...
    2023 Volume 35 Issue 1 Pages 25-31
    Published: 2023
    Released on J-STAGE: March 22, 2023
    Solitary fibrous tumors (SFTs) are undifferentiated mesenchymal tumors and their incidence has been increasing in recent years. In the stomatognathic region, SFTs commonly affect the buccal mucosa and the tongue, but there are few reports of SFTs occurring in the floor of mouth. We present a case of a SFT in the floor of mouth in a 40-year-old man who was successfully managed through surgery.
    In April 2021, a 40-year-old man presented to our department with swelling on the floor of the mouth, and on examination a 20 mm painless mass with a normal surface appearance was found. Magnetic resonance imaging revealed low-intensity signals on T1 weighted imaging, and mixed high- and low-intensity signals on T2 weighted imaging. Sublingual gland extirpation and tumorectomy were performed under general anesthesia.
    On histopathologic examination, the tumor displayed abundant collagen fibers, short spindle-shaped tumor cells, and numerous staghorn-like irregular blood vessels. The tumor tissue was observed to be mixed with glandular tissue. The tumor was positive for CD34 and STAT6 markers. These findings confirmed the diagnosis of an SFT. One year and four months postoperatively, the patient is doing well with no recurrence at the primary site and no systemic metastasis has been observed.
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