Cancer of the oral cavity occurs in individuals who neither smoke nor drink alcohol. We investigated the characteristics of patients who were never-smokers and never-drinkers (N-S/N-D) yet had oral squamous cell carcinoma (OSCC) . The records of 100 patients treated for OSCC were evaluated. All patients underwent curative resection at the Oral and Maxillofacial Surgery, Kanazawa University Hospital between 1989 and 2002. Of the 100 patients with OSCC, 47 described themselves as lifelong N-S/N-D. Patients who were N-S/N-D were more commonly women and older persons compared with ones who were ever-smokers and/or ever-drinkers (E-S/E-D) . The most frequent locations in N-S/N-D were tongue and alveolar ridge, but OSCC in floor of mouth and buccal mucosa, which was often found in E-S/E-D patients, was scarcely found among N-S/N-D. In histopathological grading, mode of invasion and survival rate, there were no statistically significant differences. Of 30 patients with OSSC in N-S/N-D, 27 cases have given birth to at least one son. Our data were consistent with the previous reports from foreign countries. Birth status could be associated with a risk factor for OSCC in N-S/N-D patients because these patients were more commonly women.

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Through a multicenter study, we aimed to provide information for the selection of treatment and reconstructive method, and improvement of their postoperative function. This study reports the results of questionnaires about the tongue/floor of mouth cancer patients who had undergone reconstruction with fasciocutaneous/myocutaneous flaps on self-assessment of postoperative function. Eighty-one patients, enrolled from 13 Japanese institutions, were classified into three groups by the site of resection: lateral (N=51), anterior (N=17), and combined (N=13) . The lateral group was divided into three subgroups and the anterior group into two subgroups by the size of resection. Reconstruction was accomplished by radial forearm flap (N=50), rectus abdominis myocutaneous flap (N=18), pectoralis major myocutaneous flap (N=11), and others (N=2) . Postoperative function was evaluated subjectively using 14 selfreporting questionnaires including four categories of speech, eating, and swallowing in oral and pharyngeal phase. The influence of site and size of resection on the functional results was investigated with that of flap. Better results were generally obtained for lateral type resections and smaller excisions. Hemiglossectomized patients in the lateral group reconstructed with a radial forearm flap could speak faster than those repaired with a rectus abdominis myocutaneous flap. Other subjective assessments were influenced by the kind of flap used.
Teaching on nutrition and care of dysphagia are important in all patients because the self assessment scone of such contents decreased postoperatively. A new modality with less functional intervention is needed especially in patients of the combined group.

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Many causes of denture papillomatosis have been reported in the literature. We experienced two cases with denture papillomatosis of the lower gingiva, lip and cheek mucosa, which were located beneath an unadapted lower full denture after many years of use. Case 1 had worn the unadapted lower denture for 15 years, and Case 2 for 10 years. The denture papillomatosis was apparently caused by chronic mechanical stimulation by the lower complete dentures.

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