Journal of Japanese Society of Oral Oncology

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Vital staining with iodine solution is a useful method to detect oral dysplastic/cancerous epithelium in the oral cavity. Several kinds of iodine solution have been used for this purpose, but the sensitivity differs among these solutions. Therefore, the purpose of this study was to determine a formula suitable for vital staining with iodine solution in oral mucosa.
Oral mucosa of five healthy volunteers was stained with eight different formulas of iodine solution (I₂ 3–10%, KI vs. NaI, KI 8–20%, Glycerin 0–80 ml). The sensitivity of detecting the boundary line between iodine-stained(nonkeratinized mucosa)and iodine-nonstained area (keratinized mucosa) and irritant behavior of iodine solutions were evaluated.
A higher concentration of iodine had a higher sensitivity and was more irritative. A higher concentration of KI revealed more mucosal irritation. The addition of glycerin made the iodine solution milder, but decreased the sensitivity of iodine staining. The results of this study suggest that iodine solution with a formula of I₂ 10 g, KI (NaI) 10 g, glycerin 40 ml/100 ml solution is suitable for iodine vital staining of oral mucosa.

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