We report a case of diffuse large B-cell lymphoma （DLBCL） of the mandible in a super-elderly patient. A 98-year-old man initially presented with pain after a facial blow. Because CT revealed a buccal cortical bone defect of the right-side mandible, a biopsy of the mandibular bone was performed. Hematoxylin and eosin staining showed a diffuse multiplication image of large atypical lymphocytes of medium size; furthermore, immunostaining for the cluster of differentiation CD20, CD79a, and B-cell lymphoma 2 （BCL-2） was positive. In FDG-PET, no site exhibited abnormal accumulation besides the mandibular bone. Therefore, we made a diagnosis of DLBCL of the mandibular bone. Because the patient was super-elderly, the patient and his family declined treatment; thus, best supportive care was provided. However, since the tumor of the mandibular bone grew and the quality of life deteriorated over time, palliative irradiation of 30Gy was performed. As a result, the tumor shrank and survival of 1 year and 8 months was obtained after radiation treatment, but the patient died of another disease.

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We report a case of clear cell carcinoma identified in the hard palate of the mouth.
A 67-year-old man was admitted to our hospital with a painless mass in his right palate. The mass beneath the mucous membrane measured 20×15mm, and had an ulcer at the center of the mass. Based on biopsy findings, a pathological diagnosis of clear cell carcinoma was made. No metastasis to the cervical node was observed. Under general anesthesia, the patient underwent partial maxillectomy and the defect was reconstructed with a buccal fat pad. After surgery, we found a naso-oral fistula at the central part of the hard palate of the mouth. The fistula was difficult to cover with upper dentures, and as a result, the patient experienced hyperrhinolalia and could not drink water. Two years after surgery, we closed the fistula using a tongue flap. His hyperrhinolalia improved, and he could drink water. As of 60 months after removal of the clear cell carcinoma, the patient remains free from disease and maintains oral function.

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Therapy-related myelodysplastic syndrome （t-MDS） is a pathological condition with quantitative and qualitative dysplasia of erythrocytes, leucocytes, and platelets after chemotherapy and/or radiotherapy for malignant tumors. Here, we report a case of carcinoma of the buccal mucosa with the development of t-MDS.
The patient was a 57-year-old male. He had noticed painful swelling and ulceration on the left buccal mucosa and visited our department. General examination revealed gastric carcinoma, which was treated with endoscopic submucosal dissection, and hypopharyngeal carcinoma. Histopathological diagnosis of a biopsied buccal mucosal material was moderately differentiated squamous cell carcinoma. Clinical diagnosis was buccal mucosal carcinoma （T4aN2bM0, Stage Ⅳa）. Functional total neck dissection, buccal mucosal tumor resection, and reconstruction by a forearm flap were performed after administration of S-1 for 2 weeks. Pathological examination revealed four regional lymph node metastases, but the surgical margin was negative. Then, combined chemotherapy （CDDP, DTX, and S-1） and chemoradiotherapy with S-1 and X-rays were performed as adjuvant therapy for buccal mucosal carcinoma and chemoradiotherapy for hypopharyngeal carcinoma. Four years after the adjuvant chemoradiotherapy, continued fever and pancytopenia were observed, and the number of myeloblasts and WT1 mRNA copies in peripheral blood increased. Bone marrow examination revealed CD13-, CD33-, and CD34-positive cells. The patient was diagnosed as t-MDS. Eleven courses of azacitidine were administered. Though the patient remitted temporarily, he died of pancytopenia.

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Ehlers-Danlos syndrome （EDS） is a rare hereditary disease characterized by joint hypermobility, skin hyperextensibility, and vascular fragility. The disorder is classified into 13 subtypes, of which vascular EDS is the most severe subtype involving high risks of artery dissection, arteriorrhexis, and rupture of the intestines.
To the best of our knowledge, there are no reports describing oral cancer occurring in an EDS patient. We present an extremely rare case of tongue carcinoma that occurred in a patient suffering from vascular EDS. A 48-year-old Japanese woman was referred to our hospital for examination of a white lesion on the left edge of the tongue, which was highly suspicious of malignancy. We performed an excisional biopsy under intravenous sedation to prevent severe complications caused by circulatory fluctuation during general anesthesia. No general complications or abnormal bleeding occurred during the operation with stable circulatory dynamics. The histopathological diagnosis was well-differentiated squamous cell carcinoma （pT1N0M0, stage Ⅰ）. Wound healing was delayed, but there has been no recurrence in the 13 months after surgery.

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