Clinical, radiological and histologic analysis of the 14 cases of fibrous dysplasia of the jaw was performed, placing special emphasis on the stage of bone formation.
The lesions were classified into four types; ground glass (7 cases), cotton wool (2 cases), mixed (3 cases) and dense calcified (2 cases), according to radiographic appearance.
The ground glass type was observed in the young patients and its main feature was a proliferation of the woven bone.
The cotton wool type was observed in patients about 30 years old. Reorganization by fusion or mass formation of the woven bones, spherical amorphous calcification and lamellar bone were seen in various places.
The mixed type was evident in the middle-aged patient group, accompanied with infection. It was chracterized by the mixed figure of cotton wool and radiolucency. Histologically, it showed condensation of woven bones or lamellar bones, and the inflammation was observed in part.
The dense calcified type was evident mainly in the alveolar area of the middle-aged group. Woven bones and lamellar bones were found to be extremely dense compared to other types.
From the above findings, it became evident that the clinicopathologic features of fibrous dysplasia covered a wide range. These variable features of the lesion could be explained as a sequential transition from the ground glass type through the cotton wool type and eventually to the dense calcified type, or to the mixed type after the exposure to infection. Furthermore, subsequent lamellar maturation may be possible

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A case of pleomorphic adenoma which recurred multinodularly in the subcutaneous tissue of the cervical region in a 32-year-old male was reported.
The cause of recurrence was guessed to be remnance and dissemination of the tumor cells during the former operation.
Tumor removal was performed like an upper neck dissection. Therefore, the skin and platysma from upper neck to lower cheek, a part of digastric muscle, submandibular gland and other tissues in submandibular triangle were resected with tumors. And after we performed the operation, 56, 000mg of UFT^® was prescribed to the patient as adjuvant therapy.
4 years and 4 months have passed since the radical operation. There have been no disturbances to him, and there have been no symptoms of side effect and recurrence.

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Resection for recurrent malignant tumors of the parotid gland may be accompanied with the full-thickness defect of the parotid-masseteric region. We reported the reconstructive technique for the full-thickness defect of the parotid-masseteric regoin with scalping forehead flap.
A 52-year-old man had the complaint of swelling in his left buccal region and visited our clinic in 1978. We performed the resection of primary tumor on the patient in 1983. The patient showed few evidences of recurrence postoperatively. The full-thickness defect, 6×3 cm in size was present in his parotid-masseteric region. We repaired the intraoral defect with hinge flap of pectoralis major myocutaneous flap and covered the extraoral defect with scalping forehead flap in 1990. By the use of this technique, we succeeded in functional and aesthetic reconstraction.

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Thirty cases of pleomorphic adenoma, treated and histopathologically proved in our department between October 1981 and September 1991, were reviwed and clinically analyzed. The patients included 8 men and 22 women, whose ages ranged from 16 to 75 years old with a mean of 46.0. Twenty-four cases were distributed in the minor salivary glands (80.0%) and 6 cases in the major salivary glands. Among the minor salivary gland lesions, the locations were the palate in 17 cases (56.7%), the buccal mucosa in 3 (10.0%), the lip in 3 (10.0%) and the tongue in 1 (3.3%) . In the major salivary gland lesions, 4 cases (13.3%) were found in the submandibular gland and 2 cases (6.7%) in the parotid gland. The pathologic diagnoses were pleomorphic adenoma in 27 cases (90.0%) and carcinoma in pleomorphic adenoma in 3 (10.0 %) . All cases of the carcinoma in pleomorphic adenoma occurred in the minor salivary glands; the palate, buccal mucosa and lip. Despite benign appearance, these cases were consequently diagnosed as carcinoma in pleomorphic adenoma, and chemotheraphy was employed postoperatively.
All the lesions in the series were surgically removed, followed by histopathologic examinations. All cases including carcinoma in pleomorphic adenoma have showed no evidence of recurrence to date. In conclusion, precise histopathologic examination is required even with benign appearance in the treatment of salivary gland tumors.

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We reported one case, in which, malignant transformation during follow-up in terval for leukoplakia, occured twice. On 2/20 1986, multiple lesions of leukoplakia existed on right upper gingiva as well as right lower gingiva, palate and right glossal border. One week later, the reversible leukoplakia lesions on right upper gingiva and palate were healed, but the leukoplakia of left glossal border appeared. On 4/3, incurable lesions of leukoplakia, of which the pathologic status was dysplasia, were excised, including safty margin. However, one month after the excision, leukoplakia recurred but was soon made less serious by the medication of UFT. On 10/14, treatment by our clinic was given up halfway, because of the general condition, in spite of the new emerengence of lower lingual gingival leukoplakia. On 11/17 1988, When the patient came to our clinic again, the squamous cell carcinoma (T1N0M0) was appeared. Partial resection practised on 12/14, after preliminary chemotherapy. At though it had been making satisfactory progress without reccurence, the squamous cell carcinoma on the right glossal border showed up in the back of leukoplakia of the same on 6/13 1991. By means of the neo-adjuvant chemotherapy and later radical therapy by interstitial irradition of ¹³⁷Cs needle, this lesion disappeared. Presently, we are cautious to reccurence and new appearance of malignant tumors.

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Fifteen parotid gland tumors treated in our department during past eight years were studied. They were composed of 11 cases which were benign tumors or tumor-like lesions, and 4 cases of malignant tumors. Histopathologically, they were composed of 8 pleomorphic adenomas, one lymphoepithelial cyst, one benign lymphoepithelial lesion with cyst, one glomus tumor, 2 mucoepidermoid carcinomas, one adenoid cystic carcinoma and one adenocarcinoma.
We reported the clinical study and the clinical course of these cases.

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The study presents 2 patients with primary oral cancer which were treated successfully with the combined neo-adjuvant chemotherapy of UFT and platinum derivatives.
Case 1: The patient was a 77-year-old woman. She had a tumor measuring 29×18mm at the right border of tongue, which was diagnosed as squamous cell carcinoma, T₂N₀M₀, Stage II, and the mode of invasion type was grade II according to the Yamamoto-Kohama's classification. UFT was daily administered at 600mg/day after the biopsy, and carboplatin (300mg/m²) was given intravenously on day 20. After these treatments, the tumor almost disappeared. The excised material was histologically estimated Grade IV according to the Ohboshi-Shimosato's classification. There has been no evidence of recurrence and metastasis during the last 6 months.
Case 2: The patient was a 58-year-old man. At the first examination, clinical findings revealed a tumor measuring about 20×15mm on the right retromolar region of mandible. It was diagnosed as squamous cell carcinoma, T₂N₁M₀, Stage III, and the mode of invasion grade I according to the Yamamoto-Kohama's classification. After the biopsy, in addition to daily administration of UFT, cisplatin (60 mg/m²) was twice given on day 14 and day 30 intravenously. After the first administration of cisplatin, the rate of tumor regression was 76%, and after the second administration, the tumor almost disappeared clinically. En bloc excision was performed under the general anesthesia and its histological findings showed Grade II b of chemotherapeutic effect according to the Ohboshi-Shimosato's classification. There has been no evdence of recurrence and metastasis during last 3 months since the operation.

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Clinical study on immediate reconstructions of mandibular defect with various reconstructive materials following mandibular resection were carried out in 32 cases during the past 8 years. The materials for mandibular reconstruction was A-O plate 24, iliac bone 6 and alumina ceramics 2.
1) A-O plate seemed to be a useful material as it could be available regardless of the extent of bone defect. However, the complications occurring in some cases increased when it was placed in long-term.
2) Application of iliac bone graft was limited in the defect size. However, it could recover the oral dysfunction and esthetic disturbance. Therefore it was useful as an eternal reconstructive material
3) Alumina ceramics was weak in strength and it was an inconvenient material because its form could not be modified during operation. However it proved to be superior to A-O plate in recovering the facial contour.

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Peripheral chondrosarcoma is a rare tumor of the jaws. We presented a case of peripheral chondrosarcoma arising from the surface of the mandible.
The patient was a 32-year-old man, complaining of swelling of the gingiva in the right molar region of the mandible. The histopathological diagnosis was peripheral chondrosarcoma.
The segmental resection of the mandible and the radical neck Bisection were performed in the patient under general anesthesia. After the operation, adjuvant chemotherapy consisting of Cyclophosphamide, Vincristine, Adriamycin and Cisplatin was given to the patient.
There has been no evidence of recurrence or metastasis in the patient 6 years after the operation.

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Hemangiomas in the oral tissues are commonly seen in the lip, tongue, cheek, and uncommonly in the masseter muscle, of which the lesion occuring in the deep portion is very rare. In this report, we present a case of intramuscular hemangioma found in the deep masseter muscle, with some discussions on the basis of literatures.
A 12-year-old-girl visited our clinic complaining about a swell in the right parotid region. Ultrasonic scanning examination showed a smooth, rounded mass, 3cm in diameter. There was a limitation in opening mouth, the interincisal distance at opening was 25mm. CT and MRI examinations revealed a soft tissue mass in the deep portion of the masseter muscle beneath the zygomatic arch.
Through a preauricular incision, the tumor was totally removed. It was histopathologically diagnosed as cavernous hemangioma. Postoperatively, the facial apperance became symmetric, facial nerve function remained intact and the interincisal distance increased to 44mm.
In the past 20 years (1970-1990) in Japan, 19 cases in 14 reports of intramuscular hemangioma of the masseter muscle were obtained.

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A case of peripheral ameloblastoma, occurred in the lingual gingiva of 3 4 of a 37-year-old female, is presented here. The patient noticed a tumor with neither symptoms nor tendency of growth about 6 months before the resection at our department. The tumor was hemi-spherical in shape, measuring 1.2×1.2×0.5mm, elastic hard in consistency, and covered with a normal mucosa. Dental x-ray films revealed radio-opacity with a focal radio-rucent area beneath the tumor. The resection of tumor was carried out at a dental clinic with a clinical diagnosis of benign tumor. Pathologically, it was diagnosed as ameloblastoma and tumor cells were observed at the surgical edge. Thereafter, the patient was referred to our department and underwent the en bloc resection of the alveolar bone of 3 4 5 area. The histology of the resected bone showed an invasion of tumor cells in the periodontal ligament of 4.
The postoperative course has shown no evidence of recurrence for about 11 months.

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Adenoid cystic carcinoma is reported as a tumor having unfavorable prognosis, because it is localy more invasive than other malignant tumors and has clinical potential for recurrence and metastasis. Concerning the treatment of this tumor, complete excision with surgery is the preferred treatment, because adenoid cystic carcinoma is not a radiosensitive tumor and the chemotherapy is not a effective treatment for this tumor. Therefore, in the intensive case of this tumor, that is unresectable, a definitive treatment is sometimes difficult.
On the other hand, the hyperthermia treatment for the malignant tumor has attracted much attention recently. This therapy has strict antitumor effect by itself as well as the synergistic effect with radiotherapy and chemotherapy, especially against the malignant adenomas.
In this report, we present a case of large adenoid cystic carcinoma affected the whole maxillaly sinus treated by combination therapy with irradiation, chemotherapy, surgical excision and hyperthermia therapy and gained a fair prognosis.

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Odontoma, an odontogenic tumor, occurs in 20% of all odontogenic benign tumors. Odontomas are classified into compound odomtomas and complex odontomas, and the latter is less common.
We report here a case of relatively large complex odontoma that was 4×2×2cm in size and occupied the whole molar area of the mandible of the left side of a 56-year-old man. The tumor was entirely resected by segmental resection of the mandible, which was immediately reconstructed with autogenous iliac bone graft. The postoperative course has been favorable. Microscopic examination of the tumor showed a characteristic finding of the complex odontoma, that is, constitution of a haphazard arrangement of enamel, dentin and cementum.
Additionally, we made a review of the literature and a clinical discussion in regarding the tumor size, location, and treatment.

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