Primary intra-osseous carcinoma (PIOC) of the jaw is uncommon and must be excludeed, in the differential diagnosis, from such as bone invasion of gingival cancer, metastatic cancer, cystic disease, and osteomyelitis. However, few studies about that have been reported. Thus, we report three cases of PIOC that we treated, and discuss its clinical and pathological features based on the literature.
Case No. 1: A 64-year-old woman was referred to our department because of swelling of her right cheek on October 16, 1995. This case was diagnosed as PIOC of the mandible. A hemi-manidibulectomy with bilateral neck dissection was performed, following chemotherapy (PEP 40mg total dose) . Neither recurrence nor metastasis has been noted during a five-year follow-up period.
Case No. 2 : A 56-year-old man was referred to our department because of continuous pain in the right side of the mandible; he visited our department on September 13, 1989. This case was diagnosed as PIOC of the mandible. Prior to surgery, he received chemotherapy (PEP 67.5mg total dose) and radiotherapy (19.5Gy total dose) . On November 10, 1989, a hemi-mandibulectomy with ipsilateral neck dissection was done. The patient has been free from the disease for five years.
Case No. 3 : A 51-year-old man, who presented with an enlargement of the hard palate, visited our department on August 20, 1999. He was finally diagnosed as PIOC arising from an odontogenic cyst. We performed a partial maxillectomy on October 4, 1999. This patient has been free from the disease for three years and four months.
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