Ventilated exterior wall systems are commonly used for low-rise buildings, such as residential houses. Because the net wind force on the external wall is the difference between external pressure and ventilation layer pressure, the load may be reduced due to the effect of pressure equalization. On the other hand, the ventilation layer pressure acts on the internal walls such as drywalls, which is not considered in the conventional wind-resistant design of walls. The present paper discusses this subject based on a wind tunnel experiment of the external pressures as well as on a numerical simulation of the vent-layer pressure. Based on both of the experimental and analytical results, wind force on each member is evaluated and a design guide is proposed for the ventilated exterior wall systems.