Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
43 巻, 2 号
選択された号の論文の22件中1~22を表示しています
EDITORIAL
REVIEW ARTICLE
  • Enyu IMAI, Yoshitaka ISAKA
    原稿種別: Others
    専門分野: Others
    2004 年 43 巻 2 号 p. 85-96
    発行日: 2004年
    公開日: 2005/01/07
    ジャーナル オープンアクセス
    Somatic cell gene therapy has made considerable progress last five years and has shown clear success in some clinical trials. In the field of nephrology, both the elucidation of pathophysiology of renal diseases and the development of gene transfer technique have become driving force for new therapy of incurable renal diseases, such as Alport syndrome and polycystic kidney disease. Gene therapy of renal cancer, although its application is limited to advanced cancer, is the front-runner of clinical application. Erythropoietin gene therapy has provided encouraging results for the treatment of anemia in uremic rats and recently progressed to the inducible one in response to hypoxia. Gene therapy for glomerulonephritis and renal fibrosis showed prominent impact on experimental models, although the safety must be confirmed for prolonged treatment. Transplant kidney is an ideal material for gene modification and induction of tolerance in the transplant kidney is an attractive challenge. Emerging techniques are becoming available such as stem cell technology and messenger RNA silencing strategies. We believe that the future of gene therapy research is exciting and promising and it holds an enormous potential for clinical application.
ORIGINAL ARTICLE
Infectious Diseases
  • Yasuo ISHIZUKA, Hiroki TSUKADA, Fumitake GEJYO
    原稿種別: Others
    専門分野: Others
    2004 年 43 巻 2 号 p. 97-101
    発行日: 2004年
    公開日: 2005/01/07
    ジャーナル オープンアクセス
      Objective  Blood (1→3)-β-D-glucan (βG) measurement is widely used as an effective sero-diagnostic method for deep-seated mycosis. Antitumor βG (lentinan, schizophyllan) administration is known as one of the false-positive factors of blood βG measurement. To understand the influence of administered βG preparation to βG measurement in blood, we compared the interfering effect of βG administration in different βG measuring methods.
      Methods  βG concentration in plasma was measured by three different methods.
      Materials  βG concentration was measured in plasma of 18 samples of 7 cases with βG administration and 86 samples without βG administration. The period after last βG administration was three days to three years.
      Results  In the cases for which βG was administered, blood βG level drastically increased using the method which employs alkaline pretreatment. Even in the cases for which βG was administered three years previously; βG value measured by alkaline pretreatment was significantly high. Thus, interference of βG administration in blood βG measurement continued for years after the last administration.
      Conclusion  Disparity in βG values measured by different methods for βG administered cases is due to differences among sample pretreatment methods. Conformation of administered βG seemed to be transformed into a sensitive form to factor G by alkaline pretreatment. Especially in the case of the alkaline pretreatment method, βG administration disturbance was much stronger than for dilution-heating pretreatment. Therefore, in suspected cases, it is important to pay attention to βG administration during the previous few years.
CASE REPORTS
Castrointestinal Diseases
Respiratory Diseases
Hematological Diseases
Rheumatic Diseases
PICTURES IN CLINICAL MEDICINE
Endocrine-Metabolic Diseases
SYMPOSIA
I.Steroid Hormones Therapies in an Aging Society
II.New Therapeutic Strategies for Atrial Fibrillation
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