Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
46 巻, 20 号
選択された号の論文の18件中1~18を表示しています
ORIGINAL ARTICLES
  • Wakoh Takahashi, Tomohide Ohnuki, Kazunari Honma, Shiaki Kawada, Shige ...
    2007 年 46 巻 20 号 p. 1679-1684
    発行日: 2007年
    公開日: 2007/10/15
    ジャーナル オープンアクセス
    Objective The aim of this study was to assess the significance of multiple risk factors for early carotid atherosclerosis in the Japanese population.
    Methods The relation between traditional vascular risk factors and serum high-sensitivity CRP (hs-CRP) or atherosclerotic lesions in the carotid arteries detected by B-mode ultrasonography was evaluated.
    Patients The subjects were 1,880 persons (1,240 men and 640 women, mean age 55+/-10 years old) without ischemic stroke, infection or collagen diseases.
    Results In the men, the odds ratio (OR) for atherosclerotic lesion was increased at 1.90 (95% CI: 1.05-3.43, P=0.032) in those with one risk factor, 2.42 (1.36-4.32, P=0.002) in those with two, and 2.95 (1.69-5.16, P<0.001) in those with three or more. In the women, the OR was similarly increased 1.93 (95% CI: 1.04-3.56, P=0.035) for one risk factor, 2.31 (1.23-4.33, P=0.009) for two, and 3.52 (1.80-6.87, P<0.001) for three or more. The mean hs-CRP concentration increased significantly with the increasing number of risk factors (men and women, P<0.001) and with the degree of carotid arterial stenosis (men, P=0.011; women, P=0.008).
    Conclusion Multiple risk factors are more predictive than a single risk factor for early carotid atherosclerosis in the Japanese population.
  • Hiroe Sato, Junichiro J Kazama, Yoko Wada, Takeshi Kuroda, Ichiei Nari ...
    2007 年 46 巻 20 号 p. 1685-1692
    発行日: 2007年
    公開日: 2007/10/15
    ジャーナル オープンアクセス
    Objective Alpha2-Heremans Schmid glycoprotein/Fetuin-A (AHSG) is a circulating negative acute-phase protein, which inhibits bimineralization. It is often considered as a potential mediator between chronic inflammation and cardiovascular diseases. The metabolism of AHSG in patients with rheumatoid arthritis (RA) is unknown.
    Methods Serum AHSG concentrations were measured in 102 patients with RA using a newly developed indirect enzyme-linked immunosorbent assay (ELISA).
    Results The serum AHSG levels in the RA patients were significantly lower than that in healthy volunteers (249.8 ± 84.1 vs 425.0 ± 93.0 μg/ml, P<0.0001). Serum C-reactive protein concentration and erythrocyte sedimentation rate were inversely correlated, while albumin, hemoglobin and total cholesterol were positively correlated with AHSG. Current serum AHSG levels did not affect the presence of aortic calcification, whereas cumulative glucocorticoid dosage was significantly related to aortic calcification (P=0.005).
    Conclusion Serum AHSG levels were significantly decreased in patients with RA. The levels reflected inflammatory and malnutritional conditions. Its role in the development of cardiovascular diseases or inflammatory bone resorption remain uncertain in RA patients.
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