Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
45 巻, 15 号
選択された号の論文の15件中1~15を表示しています
EDITORIALS
ORIGINAL ARTICLES
  • Atsushi Iwata, Shin-ichiro Miura, Kazuyuki Shirai, Akira Kawamura, Say ...
    2006 年 45 巻 15 号 p. 885-890
    発行日: 2006年
    公開日: 2006/09/01
    ジャーナル オープンアクセス
    Objective: It is unclear whether the reduction of coronary restenosis by statins is due to a decrease in low-density lipoprotein (LDL) cholesterol and/or pleiotropic effects. Therefore, we performed quantitative coronary angiography (QCA) and analyzed the lipid profile and changes in adhesion molecules and chemokines caused by statin in patients with acute myocardial infarction (AMI).
    Methods: The subjects included AMI patients who had initial coronary angiograms and significant coronary stenosis and were implanted with a stent. After stent implantation, patients were treated either with (n=36) or without (n=14) statin. The primary end-point for this study was the absolute changes in the lipid profile, C-reactive protein (CRP), adhesion molecules, chemokines and stenosis measured by QCA between the post-stent and follow-up angiogram at 6 months after stenting.
    Results: Treatment with statin reduced % coronary diameter stenosis (DS) and was associated with a greater reduction in LDL cholesterol at 6 months after stenting in patients with acute myocardial infarction (AMI), while there were no differences in adhesion molecules, chemokines, CC chemokine receptor or CXC chemokine receptor. Interestingly, changes in % DS between before and after statin treatment at 6 months (Δ%DS) were positively correlated with ΔLDL cholesterol, and patients who had an LDL cholesterol level of less than 80 mg/dl had a significantly lower Δ%DS. In addition, Δ%DS was significantly related only to the reduction in LDL cholesterol as assessed by a stepwise multivariable regression analysis.
    Conclusion: These results suggest that the lower level of LDL cholesterol is the most critical factor in preventing coronary restenosis.
  • Mitsuyo Okada, Akemi Takamizawa, Kenji Tsushima, Kazuhisa Urushihata, ...
    2006 年 45 巻 15 号 p. 891-896
    発行日: 2006年
    公開日: 2006/09/01
    ジャーナル オープンアクセス
    Objective: Simplified sleep polysomnography was performed in 207 adult men to examine the relationship between the frequency of sleep-disordered breathing (SDB) and lifestyle-related illness.
    Methods: Each subject was checked for SDB using a simplified sleep polysomnograph (Auto-Set Portable; Teijin Limited, Tokyo, Japan). Apnea and hypopnea were detected with a nasal cannula type airflow sensor. Hypoxemia was checked with a percutaneous oxygen saturation (SpO2) monitor. We analyzed the relationships between SDB and body mass index (BMI) and hypertension, hyperlipidemia, liver dysfunction, fatty liver, and abnormal glucose metabolism.
    Results: Fifty-nine subjects (29%) showed SDB with apnea hypopnea index (AHI) over 15 times/h. The frequency of obesity (BMI≥25), hypertension, hypercholesterolemia, fasting blood glucose level, and HbA1c were significantly higher in patients with SDB than in normal individuals (AHI<5 times/h). The frequencies of hypertension, hyperlipidemia, and abnormal glucose metabolism were compared between the obesity-free normal AHI group and the SDB group, and only that of hypertension was significantly different between the two groups.
    Conclusions: The present study revealed a high frequency of SDB among Japanese individuals. The results also suggest that as SDB becomes severe, it becomes more closely linked to the onset of lifestyle-related illnesses, such as hypertension, hypercholesterolemia and abnormal glucose metabolism.
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