We reviewed studies of infantile lead encephalopathy published in Acta Paediatrica Japonica between 1936 and 1944, (Volumes 428～437 and 43 Issue 1～49 Issue 2). In this review article, 17 representative articles were discussed. The articles include two review articles, four statistical articles, and eleven case reports, which were categorized based on their content.

The great statue of Buddha in Toudaiji-temple in Nara (it’s so called Nara-Daibutsu) was constructed in 749 and gilded for 5years after built.

The “amalgam-method”, was applied to the gilding. At first, statue was coated with gold- amalgam, mercury was evaporated by heating next, and gold was plated on the surface.

It is said that many workers were poisoned by the vaper of mercury, but the basis of the theory is not be cleared.

In this report, the possibility of poisoning by the gilding work was studied from the risk evaluation way in the risk assessment.

As a result, it is cleared that the risk of the gilding work was dangerous level, and many workers must be poisoned by mercury.

The purpose of this study is to investigate the objective effects of alcohol to sleep in daily life. We obtained 43 and 37 night sleep data from two participants by sheet-shaped body vibrometer (SBV). We evaluated parameters measured by SBV, containing 9 sleep variables and 3 physiological indices (activity score, respiratory rate, heart rate). As a result, drinking alcohol caused significantly increased respiratory rate and heart rate for both of participants, and also caused significantly delayed bedtime or increased WASO (wake time after sleep onset) in each participants. This study revealed that it is enable to detect sleep worsening effect of drinking alcohol based on several tens of measurements of sleep variables and physiological indices in daily life. In addition, it is suggested that evaluation based on sleep variables underestimate the effect of drinking, and it seems useful to evaluate respiratory rate and heart rate in sleep time.