The effects of plasmin and anti-plasmin on an experimental cerebrovascular occlusion were observed in dogs. It was suggested that plasmin would inhibit the progress of local ischemic changes by enhancing collateral circulation when used in an early stage of the disease, but it would merely increase the risk of hemorrhage when used in the cases where vascular changes have already developed. Ipsilon treatment after the occlusion apparently reduced angionecrotic changes and hemorrhagic tendency at the affected area, indicating a marked suppressing effect for the local hyperplasmic state due to the vascular occlusion.

抄録全体を表示

Purpose Since Rinehart has succeeded to cause arteriosclerosis in monkeys by administration of B₆ deficient diet, many studies on the relationship between B₆ and arteriosclerosis have been reported. Recently in our clinic, it was succeeded to cause arteriosclerosis in B₆ deficient monkeys. Many factors to cause arteriosclerosis have been considered but they have not been clarified yet. However, it is supposed that metabolic disturbances of the high energy phosphate due to B₆ deficiency may accelerate the occurrence of arteriosclerosis. Since Hahn has reported the relationship between Lipemia Clearing Factor (LCF) and arteriosclerosis, many similar studies have been reported. In one of them, it was reported that LCF was decreased by B₆ deficiency and could be restored by the administration of pyridoxal phosphate (PAL-P). It may suggest there is a close relationship between B₆ (active form) and LCF. Considering of these observations, the author has studied the effect of B₆ on the experimental arteriosclerosis in rabbits. Method s Both preventive and therapeutical experiments were performed. Preventive experiment : Pyridoxine (PIN), PAL-P or pyridoxamine phosphate (PAM:-P) (respectively 10mg/day) was injected, while administering lanolin in rabbits. The data were compared with those of the noninjected control group. Therapeutic experiment : 1) In rabbits, which were made arteriosclerotic by lanolin administration for 1 6 weeks, PIN, PAL-P or PAM-P was injected and usual diet was given for 1 2 weeks. And the data were compared with those of the noninjected group. 2) In rabbits, which were made arteriosclerotic by the same procedure, the effects of the combined treatment with PIN or PAL-P injection and lanolin feeding for 12 weeks were studied. In the above experiments, serum total cholesterol and phospholipids were determined and then, the animals were killed after 12 weeks and investigated histologically.

抄録全体を表示