JAPANESE CIRCULATION JOURNAL

Role of the Renin-Angiotensin System in Pathogenesis of Experimental Renal Hypertension

JUN FUJII, MASAO IKEDA

1971 年 35 巻 5 号 p. 493-498
発行日: 1971/06/20
公開日: 2008/04/14

DOIhttps://doi.org/10.1253/jcj.35.493

ジャーナルフリー

抄録を表示する抄録を非表示にする

Plasma renin activity (PRA) was measured in rabbits by a modification of Picken's method. In the acute stage, PRA increased in 5 of 11 animals with unilateral constriction of renal artery but it did not increase in 13 of 15 animals with bilateral constriction of renal arteries. No clear correlation was found between PRA and blood pressure. In the chronic stage, PRA increased in 6 of 32 animals with unilateral constriction of renal artery. There were a positive correlation between PRA and blood pressure, and a negative correlation between PRA and serum potassium level. However, there were hypertensive animals without increase in PRA. Removal of the clipped kidney was followed by a fall of blood pressure in chronic hypertensive animals. The fall of blood pressure did not depend upon the previous level of PRA. These results suggest that the renin-angiotensin system does not play a primary role in the pathogenesis of experimental renal hypertension and unknown renal mechanism may be involved in it.

抄録全体を表示

PDF形式でダウンロード (585K)
Significance of the Renin-Angiotensin System on the Development of Hypertension and the Maintenance of Elevated Blood Pressure Levels

TATSUO KOKUBU

1971 年 35 巻 5 号 p. 499-501
発行日: 1971/06/20
公開日: 2008/04/14

DOIhttps://doi.org/10.1253/jcj.35.499

ジャーナルフリー

PDF形式でダウンロード (358K)
Interpretation by the Deficiency Theory

HIROFUMI SAKABE

1971 年 35 巻 5 号 p. 503-504
発行日: 1971/06/20
公開日: 2008/04/14

DOIhttps://doi.org/10.1253/jcj.35.503

ジャーナルフリー

PDF形式でダウンロード (258K)
Interaction of Angiotensin and Noradrenaline in Rat's Hindlimb Preparation. : A Possible Mechanism of the Experimental Renal Hypertension

RIHEI SATO, YOSHIAKI MASUYAMA

1971 年 35 巻 5 号 p. 505-509
発行日: 1971/06/20
公開日: 2008/04/14

DOIhttps://doi.org/10.1253/jcj.35.505

ジャーナルフリー

抄録を表示する抄録を非表示にする

Interaction of angiotensin and noradrenaline on vascular responsiveness were investigated in the isolated rat's hindlimb preparations perfused with Tyrode solution in low perfusion pressure. Highly significant enhancement of responses to noradrenaline occurred in angiotensin infusion with concentration influenced or uninfluenced to the perfusion pressure. Diminished responses of repeated application of angiotensin, tachyphylaxis, easily produced in the preparation, were promptly reversed by an application of noradrenaline and no tachyphylaxis was made as far as both sub-stances were alternately administered. In the possible mechanism of the experimental renal hypertension, the participation of interaction in renin-angiotensin and sympathetic neurohumoral agent on the peripheral sites of the circulating system were suggested.

抄録全体を表示

PDF形式でダウンロード (485K)
Studies on the Ftiology of Essential Hypertension : a Role of Sympathetic Nervous System

TSUYOSHI KURIKI

1971 年 35 巻 5 号 p. 511-512
発行日: 1971/06/20
公開日: 2008/04/14

DOIhttps://doi.org/10.1253/jcj.35.511

ジャーナルフリー

PDF形式でダウンロード (314K)
On the Role of Aldosterone to Hypertension ; Especially an Extent of Its Participation

TATSUO ODA

1971 年 35 巻 5 号 p. 513-518
発行日: 1971/06/20
公開日: 2008/11/07

DOIhttps://doi.org/10.1253/jcj.35.513

ジャーナルフリー

抄録を表示する抄録を非表示にする

1) A role of aldosterone in the etiology of essential hypertension is yet obscure ; except severe and malignant hypertension which have an increased renal damage. However in the latter two diseases aldosterone has some significance in the maintenance of hypertension. 2) We have found the cases with primary aldosteronism showed a normokalemic stage especially in their initial stadium. 3) In our experienced cases of primary aldosteronism there were some cases of so-called secondary primary aldosteronism with bilateral adrenocortical hyperplasia (zona glomnerulosa). 4) In diagnoses of primary aldosteronism only the suppression of P.R.A. response is not satisfied and the existence of hyperaldosteronism must be recognized, because not a little percentage out of essential hypertension show often a low P.R.A. and P.R.A. response to sodium restriction and upright position. More sensitive and accurate method of determining plasma renin is necessary to resolve the problem which include a true incidence of primary aldosteronism in essential hypertension. 5) From our cases histologically the following possibility was considered that first zona glomerulosa caused hyperplasia and thereafter gradually transit to adenomatous hyperplasia and matured adenoma.

抄録全体を表示

PDF形式でダウンロード (1067K)
The Role of Aldosterone in Pathogenesis of Artenal Hypertension

SOITSU FUKUCHI

1971 年 35 巻 5 号 p. 519-521
発行日: 1971/06/20
公開日: 2008/04/14

DOIhttps://doi.org/10.1253/jcj.35.519

ジャーナルフリー

PDF形式でダウンロード (332K)
The Electrolyte Metabolism as a Pathogenetic Factor in Hypertension

CHUJIRO KASHII

1971 年 35 巻 5 号 p. 523-529
発行日: 1971/06/20
公開日: 2008/04/14

DOIhttps://doi.org/10.1253/jcj.35.523

ジャーナルフリー

PDF形式でダウンロード (594K)
Sodium and Hypertension

SUSUMU YORIFUJI

1971 年 35 巻 5 号 p. 531-532
発行日: 1971/06/20
公開日: 2008/04/14

DOIhttps://doi.org/10.1253/jcj.35.531

ジャーナルフリー

PDF形式でダウンロード (307K)
The Effect of Sodium and Potassium Ions on the Contractility of a Contractile Protein Extracted from Arterial Wall

NOBUHIKO SHIBATA, TORU YAMAGAMI, HIROTAKA AKAGAMI

1971 年 35 巻 5 号 p. 533-539
発行日: 1971/06/20
公開日: 2008/04/14

DOIhttps://doi.org/10.1253/jcj.35.533

ジャーナルフリー

抄録を表示する抄録を非表示にする

1. An attempt was made to clarify the role of NaCl for the induction of hypertension via the effeet of NaCl on the contraction and relaxation mechanism of the arterial wall with use of myosin B and microsomal fraction prepared from the bovine carotid artery. 2. The microsomal fraction was capable of taking up calcium in the presence of Mg⁺⁺ and ATP, but the capacity was very weak and very low. 3. The microsomal fraction also inhibited the superprecipitation of arterial myosin B in a slight degree. The further study is required in order to clarify the exact mechanism. 4. Elevation of the ratio of NaCl to KCl in a reaction mixture led to enhance the super-precipitation of arterial myosin B with or without the microsomal fraction. This finding might lead to on assumption that the elevation of the ratio of NaCl to KCl in arterial smooth muscle enhanced the contraction of the arterial wall, resulting in an increase of peripheral arterial resistance followed by high blood pressure.

抄録全体を表示

PDF形式でダウンロード (1174K)
Indications of Operation upon the Heart as viewed from Coronary Arteriographic Findings

YOSHIHIKO ISHIGURO

1971 年 35 巻 5 号 p. 547-551
発行日: 1971/06/20
公開日: 2008/04/14

DOIhttps://doi.org/10.1253/jcj.35.547

ジャーナルフリー

PDF形式でダウンロード (1767K)
Some Correlations between the Findings of Preoperative Coronary Arteriography and Benefit of Vineberg's Operation

KOKI ABE

1971 年 35 巻 5 号 p. 553-554
発行日: 1971/06/20
公開日: 2008/04/14

DOIhttps://doi.org/10.1253/jcj.35.553

ジャーナルフリー

PDF形式でダウンロード (314K)
The Clinical Experience of the Internal Mammary Artery Implantation for Ischemic Heart Disease

FUSAYOSHI TOMITA

1971 年 35 巻 5 号 p. 555-556
発行日: 1971/06/20
公開日: 2008/04/14

DOIhttps://doi.org/10.1253/jcj.35.555

ジャーナルフリー

PDF形式でダウンロード (296K)
Internal Mammary Artery Implantation Experimental and Clinical Analysis of the Effects of Implantation on the Ischemic Myocardium

AKIRA NONOYAMA

1971 年 35 巻 5 号 p. 557-563
発行日: 1971/06/20
公開日: 2008/04/14

DOIhttps://doi.org/10.1253/jcj.35.557

ジャーナルフリー

PDF形式でダウンロード (1302K)
Infarctectomy

HIROO HIRATSUKA

1971 年 35 巻 5 号 p. 565-566
発行日: 1971/06/20
公開日: 2008/04/14

DOIhttps://doi.org/10.1253/jcj.35.565

ジャーナルフリー

PDF形式でダウンロード (304K)
An Internist's View on the Indication for Surgical Treatment of Ischemic Heart Diseases

SHOJI HAYASE

1971 年 35 巻 5 号 p. 567-568
発行日: 1971/06/20
公開日: 2008/04/14

DOIhttps://doi.org/10.1253/jcj.35.567

ジャーナルフリー

PDF形式でダウンロード (313K)
CONTROL OF RENIN SECRETION IN THE ANESTHETIZED DOG (3) EFFECTS OF HYPERTONIC MANNITOL INFUSION

KENJIRO YAMAMOTO, MIZUO MIYAZAKI, TAKAMICHI HASEGAWA, JURO UEDA

1971 年 35 巻 5 号 p. 573-577
発行日: 1971/06/20
公開日: 2008/04/14

DOIhttps://doi.org/10.1253/jcj.35.573

ジャーナルフリー

抄録を表示する抄録を非表示にする

1. Effects of hypertonic mannitol infusion on renin secretion and renal function were studied in anesthetized eviscerated dogs. 2. Hypertonic mannitol infusion increased urine flow and urinary sodium excretion but decreased hematocrit, plasma sodium concentration and GFR. 3. Renin secretion rate markedly increased and showing an inverse relation to GFR and to tubular sodium load. 4. In references to the previous findings, it was suggested that an important factor in controling renin secretion was dependent on resultant phenomena from a reduction of GFR, rather than on renal vascular state.

抄録全体を表示

PDF形式でダウンロード (515K)

J-STAGEへの登録はこちら（無料）