QA2 interval, preejection period and ejection time were calculated from the data of simultaneously recorded ECG, PCG, and external carotid arterial pulse wave in patients with adrenocortical overfunction, namely, Cushing's syndrome and primary aldosteronism, and in patients with nephrotic syndrome or collagen disease under longterm treatments with large doses of glucocorticoids.
PEP/ET ratio, which is considered inversely related to the maximal dp/dt of the left ventricle, was markedly increased in the patients with Cushing's syndrome, and in those who were treated with large doses of glucocorticoids for prolonged periods. The PEP/ET ratio in the patients with primary aldosteronism was also increased but not so marked. These results suggest that longterm use of large doses of glucocorticoids impairs the myocardial contractility.

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The haemodynamic effect and isoprenaline antagonism of a new beta adrenergic blocking drug, Kö 1366, was investigated in healthy volunteers, comparing with the effect of propranolol. Furtheremore Kö 1366 was administered to patients with ischaemic heart disease for measurement of heart rate, blood pressure and cardiac effort index at rest and on exercise.
Following intravenous administration of 1, 2, 2.5, and 3mg Kö 1366, changes in heart rate, blood pressure and cardiac effort index were observed. 2.5-3mg Kö 1366 was roughly equivalent in potency to 10mg of propranolol intravenously administered. In respect of decrease in cardiac index and stroke volume index, 2.5mg Kö 1366 intravenously administered was equivalent to or slightly less effective than 10mg propranolol. In terms of isoprenaline antagonism, the effect of 3mg Kö 1366 on heart rate was more marked than that of 10mg propranolol, and on cardiac effort index 1mg of Kö 1366 was more active than 10mg of propranolol. The inhibiting effect on cardiac index increase following isoprenaline was less pronounced than that by 10mg propranolol, and that of Kö 1366 on stroke volume index increase was nearly equivalent to that of propranolol. From these results, the Kö 1366 to propranolol potency ratio is estimated at 3-4 to 1.
After oral administration of 10-45mg per day of Kö 1366 to patients with ischaemic heart disease, heart rate, blood pressure and cardiac effort index were measured at rest and on exercise. It was found that Kö 1366 produced a slight decrease in heart rate, blood pressure and cardiac effort index at rest, but increases in heart rate, cardiac effort index and blood pressure on exercise were considerably inhibited by doses of 15mg or more. Fifteen to 30mg Kö 1366 is considered a suitable daily dose in the treatment of the patients with ischaemic heart disease.

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A method was devised for measuring a blood flow signal from a body in intact state. When a body was placed in a high magnetic field, blood flow induced EMF was detected with surface electrodes using the same principle as an electromagnetic flowmeter. This method was named Magnetorheography (its recording: MRG).
This experiment was made on human subjects. The MRG from the wrist, chest and abdomen, was detected by this method.

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ATPase activity of myofibrils and Ca²⁺ binding ability of sarcoplasmic reticulum isolated from the hearts of spontaneously hypertensive rats (OkamotoAoki strain, SHR) and normotensive Wistar rats (NR) were measured. Myofibrils isolated from both the hearts of SHR and NR showed essentially the same activity either in the absence or presence of Ca²⁺. On the other hand, Ca²⁺ activated ATPase activity of relaxed preparation of myofibrils from SHR was significantly lower than that from NR
The maximum Ca²⁺ binding capacity of sarcoplasmic reticulum (SR) from SHR (8.80±0.33nmoles/mg) was significantly lower than that from NR (11.95±0.55). Also, SR from SHR had significantly elevated Ca²⁺ activated ATPase activity (0.171±0.009μmoles/mg/min) compared with that of NR (0.100±0.009). Values were expressed as mean±s.e.m.
Reduction of Ca²⁺ binding capacity of SR may result in increase of intracellular free Ca²⁺ concentration which probably be one of the important factor for muscle contraction. If the abnormal intracellular distribution of Ca²⁺ is associated with the smooth muscle of cardiovascular system, it would cause the increase of vascular resistance resulting in hypertension.

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We established a 17 days survival with an implanted total artificial heart in a calf. The blood contact surface was made of aldehyde treated bovine pericardium and the outer surface was reinforced with specially treated natural rubber. The artificial heart used could pump by pneumatical driving system more than 11L/min of water in vitro and around 10L/min of blood in the experimental animal and was able to maintain hemodynamics within normal ranges for 17 days without difficulty. Though to keep hematological and biochemical parameters within normal ranges was relatively difficult, thromboembolism and disseminated coagulopathy characterized by bleeding were not large troubles at all. The main cause of death was breakage of the heart terminated in air embolism in the cerebral arteries.

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Renovascular hypertension was produced in Wistar-King strain female rats by left renal artery clipping. The clipped kidney and the contralateral untouched kidney were cut into cortical, corticomedullary and medullary portion. The cortical extract was divided into subcellular fractions by the stepwise centrifugation method. Enzyme activity of acid phosphatase, cytochrome C oxidase and glucose-6-phosphatase was determined to ascertain the nomenclature of each fraction.
Renin content in these fractions was determined by bioassay and it was expressed as equivalent activity of angiotensin II per mg of tissue protein.
Renin content in whole kidney extract of the clipped kidney was 2 times higher than that in the normal kidney described in our previous report. Cortex had also high renin content and it was 2 times higher than in the normal kidney, while medulla did not show any renin activity as well as that in the normal kidney. The renin content was highest in lysosomal fraction, which was 4 times greater than that in the normal kidney. Mitochondrial, mitochondrialmicrosomal or soluble fraction had also higher renin content than respective fraction in the normal kidney. No renin activity was found in microsomal fraction as well as in that fraction in the normal kidney.
In the contralateral untouched kidney, renin activity could not be demonstrated in any of the extracts or subcellular fractions.

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1) The ventricular fusion beat was produced in dogs with atrial pacing and the stimulation of various sites of ventricle. The interval between atrial and ventricular stimulation was controlled by a preset timer with a step of 1msec.
2) The limit of the range of the AV stimulation interval (D₁ and D₂) for the fusion beat was related to the normal activation time of the location of the ventricular stimulation.
3) The QRS morphology corresponding to the A type of WPW syndrome was obtained from the stimulation of posterior and lateral wall of the LV, that to B type from the base of the RV, and that to C type from the septal area of the LV, the posterior basal part and tha apical 2/3 of the RV.
4) The longer interval of the atrial and ventricular stimulation caused the B type QRS at any site of the ventricular stimulation.

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A case with coronary artery fistula, in which branches of both right and left coronary arteries were communicating to the pulmonary artery, was reported. The selective coronary arteriograms revealed also a small caliber of the left circumflex coronary artery beyond the branching point of the fistulous vessel and preponderance of the right coronary artery.

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A case of primary rhabdomyosarcoma is reported with various electrocardiographic findings during clinical course. At autopsy an atrioventricular node was found to be replaced by tumor tissue which was diagnosed histologically as rhabdomyosarcoma of the pleomorphic type.

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