The influence of silicosis, alluminosis and titanosis on pulmonary tuberculosis was investigated by studies of calcium metabolism and pulmonary functions. The results of these studies led the author to the following conclusions. 1) Clinically, silicosis appears to have some adverse effects on pulmonary tuberculosis as revealed by pulmonary function studies. 2) The serum calcium level is higher in patients with pulmonary silicotuberculosis than in those with pulmonary tuberculosis. This might suggest that silicosis has a good effect on pulmonary tuberculosis. However, in the early stage of experimental pulmonary silico-tuberculosis the serum calcium level is lowered. Differences in these results are probably due to the different stages of the disease. If the experiments were performed at different stages, the results would perhaps be the same as in our human patients. 3) Animals with early experimental pneumoconiosis, including silicosis, show some differences in the calcium level, depending on the serum, the kind of the tissue, and the kind and the amount of the dust used. However, the addition of pulmonary tuberculosis to all types of pneumoconiosis affects calcium metabosism adversely. The addition of pneumocociosis to tuberculosis, however, does not always lower the calcium level. In general, either pneumoconiosis or pulmonary ruberculosis increases the abnormality in the calcium metabolism of the other. Histological examinations showed that the addition of pneumosoniosis to tuberculosis always cause pulmonary lesins to enlarge. However, the addition of tuberculosis to pneumoconiosis causes no change in the histological appearance. Thus, changes in the calcium level are not always related to tissue degeneration. 4) It is probable that some of the differences in the above results are due to differences in the methods used on experimental animals, and espesially to different stages of the disease. It is expected that further clinical and experimental studies on these topics will reveal interesting and important findings.

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Through general observation and biometry, examinations of tendon reflex and mobility of coxa, audiometry and x-ray of the lower extremities upon twenty motorboat racers in Japan in 1964, the following conclusions were acquired: 1. Although it seems recently that younger racers become smaller gradually, the results of the various examminations did not show any particular inferiority. 2. The longer the career, the higher the threshold of the Achilles tendon reflex in the both sides. As this relationship did not appear in the threshold of the knee-jeck reflex, this may not be attributed to the vacation, characterized by the act of maintaining the posture during the race. If this reflex be examined on the beginner, the relationship might be classified. 3. Some of the racers showed a lowering of audiotory acuity at 4, 036 c.p.s. and 8, 192 c.p.s. With the lack of date at the begining period, a comparative study was impossible, but it seems necessary to examine such disabled racers. There were many racers who complained of audiotory defects resulting from mechanical trauma. The trauma was caused by throwing out and hitting their left ear against water during the race. 4. The radiological findings were arthrosis deformans on the talus, on naviculare pedis and phalanges. The changes may be resulted from the load imposed upon the surface of the bones composed of these joints by the posture during the race. Many racers offered lumbago. As it might be possible that the posture and the repeated impacts caused the cahange of the spinal column, it is necessary to take X-ray pictures of the spine, knee, ankle and toes at the acceptance of racers. A systematic medical examination should be carried out at least twice a year in order to insure the health of the motorboat racers.

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The experiment with rabbits was to show whether CHCl₃ and C₂H₅OH were effective or not as the secondary or booster exposure of detecting inapparent industrial poisoning of CCl₄. Results were as follows. (1) There appeared no change at all in plasma GPT activities when CHCl₃ at 0.1cc/kg was administered to the normal rabbits. And after repeated administrations of a small dose of CCl₄ for 5 weeks, there was no change in GPT activities either. Receiving booster injection of a single dose of CHCl₃ at 0.1cc/kg the animals reacted to the dose by an apparent increase of plasma GPT activities this time. This result implies that CHCl₃ was effective as a secondary or booster exposure to detect the inapparent poisoning of CCl₄. (2) There was no change in plasma GPT activities when 50% C₂H₅OH at 10 cc/kg was subcutaneously injected to the chronically CCl₄ poisoned rabbits. This result meant that C₂H₅OH was not effective as a secondary or booster exposure to detect the inapparent poisoning of CCl₄. (3) The authors discussed that CCl₄ and CHCl₃ were effective as the secondary or booster exposure to detect the inapparent poisoning of CCl₄, and that the action of CCl₄ and CHCl₃ upon the inapparently poisoned animals had not yet been confirmed.

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