Based on a suggestion of Prof. M. KONUMA, a study of the "epileptoid character" as related to occupation and constitution was conducted on applicants for drivers of a certain factory. The so-colled "epileptoid character" here is a character apparently rather normal and is much like the one following epileptics, i.e. neither psychopathic nor laden with pileptic diseases. As interesting results were observed in the survey, they are presented in this report. 1) "Epileptoid character" was note in 76 out of 200 subjects observed, i.e. in 38.0 percent. 2) Certain abnormal findings were noted in 14 out of the 76 cases on electroencephalography, as high as 18.4 percent, but those findings were considered to have no relations to epileptic nature. 3) This character was found in 78 out of 166 fathers of these 200 subjects (46.9 percent) and 30 out of 190 mothers (15.7 percent), respectively. Thus, this character was noted at a higher ratio among the fathers than the mothers. 4) The character was also found in 156 out of 667 siblings of these 200 subjects (23.4 percent). The character was noted at a higher ratio among the brothers than the sisters. 5) Frequency of alcoholic intolerance and potator strenuus as related to the "epileptoid character" was studied. Results indicated that alcoholic intolerance was found in 56 out of the 76 cases with "epileptoid character" (73.6 percent). On the other hand, potator strenuus was found in 7 (9.2 percent). 6) The above results prove that there are a remarkable amount of cases of rather special character trends as "epileptoid" in the workship of applicants of drivers, and that there may exist many problems regarding evaluation of merits and demerits of the "epileptoid character" as related to work in various industries and occupations from the practical stand point.

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In the two previous reports, the author has reported on the effects of noise on ECG and serum electrolytes, i.e. an increase in T voltage, a slight decrease in serum sodium concentration and no significant variation in serum potassium concentration. The relation between ECG and concentrations of serum or heart muscle electrolytes due to exposure to noise to noise in male adult rabbits as investigated. The animals were divided into 3 groups, as follow: group A ...... number of animals 4 ...... single exposure to noise (100∼105 phon, 3 hours) group B ...... number of animals 6 ...... lons-run exposure to noise (95 phon, 15 hours/day, 3 months) group C ...... number of animals 6 ...... control group ECG was recorded by limb leads. Sodium and potassium concentrations in serum and in heart muscle were determined by flame photometry. As to ECG, R wave amplitudes after exposure were higher in group A and lower in group B than before exposure. No changes of T heights were observed in 2 experimental groups, but potassium concentrations in serum were lower in group A than C. In myocardial tissues, variations of sodium concentrations were not significant in all groups, but potassium concentrations were higher in groups A and B than C.

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Ointments composed of azulen dehydroxyacetate and carboxymethyl-cellulose (A-CMC) or polyvinyl-pyridin (A-PVC) were used for cure and prevention of disorders of the skin and the mucous membrane. 1. By application of A-CMC, time of disappearance of dermatographic signs on the forearm of man was shortened, and dermatitis of rabbits by arsenites was prevented. 2. Application of A-PVP to the eye of rabbits, of which conjunctiva were made hyperemic and edematous by abrasion, caused more rapid disappearance of these symptoms without any side-effects. No side-effects were also observed in repeated applications to the nasal mucous membrnane of new-born infants. 3. The application of A-PVP to the nasal mucous membrane did not affect its excreting functions, and it prolonged the duration of enhanced air passage. 4. Inhalation of A-PVP prevented or cured inflammation of the respiratory tract of rabbits. 5. In arsenite plants, application of A-CMC decreased morbidity of dermatitis, and application of A-PVP not only cured cases of conjunctivitis and inflammation of the upper respiratory tract but also decreased their incidence. PVP as well as CMC, as high-molecular amphoteric substances, have non-osmotic protective effects due to its adsorptive, imbibitive and other characteristics. These effects combined with antiphlogistic and anti-allergic effects of azulen seem to provide excellent ointments not inferior to the existing ones for cure and prevention of disorders of the skin and the mucous membrane.

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