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Volume 30 (1989)
- Issue 4 Pages 323-
- Issue 3 Pages 209-
- Issue 2 Pages 155-
- Issue 1 Pages 112-
Volume 30, Issue 2
Displaying 1-4 of 4 articles from this issue
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YUKIO SATOW, JUING-YI LEE, HIROSHI HORI, HIROE OKUDA, SHIGEO TSUCHIMOT ...1989 Volume 30 Issue 2 Pages 155-163
Published: June 15, 1989
Released on J-STAGE: June 16, 2006
JOURNAL FREE ACCESSThe teratogenicity of Californium-252 (Cf-252) irradiation which generates approximately 7010 2.3 MeV fast neutron and 30% gamma rays was evaluated. A single whole body exposure of Cf-252 at various doses was given to pregnant rats on day 8 or 9 of pregnancy, followed by microscopic autopsy of the fetuses at the terminal stage of pregnancy to search for external and internal malformations. For comparison, pregnant rats were irradiated with various doses of Cobalt-60 (Co-60) standard gamma rays at the same dose rate (1 rad/min.). The doses were 20-120 rad of Cf-252 and 80-220 rad of Co-60. Using frequency of radiation induced malformations observed on day 8 of pregnancy as an index, relative biological effectiveness (RBE) of 2.3-2.7 was obtained from the straight line obtained by modifying by the least squares method the frequency curves of malformed fetuses in total implants and in surviving fetuses. The types of malformations induced by Cf-252 and Co-60 irradiation were alike. Using fetal LD50 as an index, 2.4 was obtained as RBE when irradiated on day 8 of pregnancy and 3.1 as that when irradiated on day 9. The results showed that Cf-252 had stronger a teratogenic effect than Co-60 gamma rays.View full abstractDownload PDF (337K) -
CHIKAKO ITO, MASAFUMI KATO, TSUTOMU YAMAMOTO, NOBUHIRO OTA, TANEOMI OK ...1989 Volume 30 Issue 2 Pages 164-175
Published: June 15, 1989
Released on J-STAGE: June 16, 2006
JOURNAL FREE ACCESSFor the purpose of studying the histological findings and prognosis of stomach cancer in atomic bomb survivors, a histological diagnosis of 600 cases of stomach cancer observed between 1964 and 1986 in three medical institutions in Hiroshima City was made by a single pathologist and, furthermore, analysis of 231 cases thereof was performed using the DS86 dose estimated by the Radiation Effects Research Foundation.
1) By histological type of stomach cancer, the frequency of poorly differentiated adenocarcinoma (poorly differentiated adenocarcinoma and signet ring cell carcinoma) was significantly higher in the 1 rad or more group (average stomach organ dose of 30.6 rad) than in the 0 rad group.
2) As for stromal type, the frequency of scirrhous type was significantly higher in the 1 rad or more group, but no difference in infiltrative behavior could be demonstrated.
3) Early cancer tended to be observed at a low rate in the 1 rad or more group.
4) As for average survival time, of the early cancers only well differentiated adenocarcinoma showed a significantly lower survival time in the 1 rad or more group when compared to the 0 rad group.View full abstractDownload PDF (509K) -
SENTARO TAKAHASHI, YOICHI OGHISO, HIROSHI SATO, YOSHIHISA KUBOTA1989 Volume 30 Issue 2 Pages 176-184
Published: June 15, 1989
Released on J-STAGE: June 16, 2006
JOURNAL FREE ACCESSFemale C3H/He mice, aged 12-17 weeks, were injected intravenously with 89SrCl2 at doses of 0.74kBq g-1 body weight (low dose) or 74.0kBq g-1 (high dose). During the first week after injection, approximately 45% of the injected 89Sr was excreted in the urine and feces in both dose groups. The excretion of 89Sr decreased thereafter. The total excretion up to 56 days after injection was 63.0% and 64.5% of the injected dose in the high and low dose groups, respectively. There was no significant difference in the excretion of 89Sr in the urine between the two groups, while the fecal excretion in the low dose group was slightly higher than in the high dose group. The retention of 89Sr in the right and left femurs was 1.30 and 1.46% of the injected dose on day 7, which decreased to 0.64 and 0.70% on day 56, in the high and low dose groups, respectively. No significant difference was observed in bone retention of 89Sr between the two groups. The amount of 89Sr distributed to the soft tissues was very small and became undetectable by 42 days after injection.View full abstractDownload PDF (381K) -
HIROYUKI TATENO, KAZUYA MIKAMO1989 Volume 30 Issue 2 Pages 185-190
Published: June 15, 1989
Released on J-STAGE: June 16, 2006
JOURNAL FREE ACCESSThe fertility span between the first and the last estrus was compared among female Chinese hamsters exposed to 1 Gy X-rays on neonatal day 0, 2, 4, 6, 8, 10 and 14. The fertility span changed dramatically according to the age at the time of irradiation. The females irradiated on day 4, 6 and 8 showed a definite delay in sexual maturation and a very early cessation of the estrous cycles, while those irradiated on day 10, 2 and 14 (in this order) showed a much longer, nevertheless significantly shortened, fertility span. Reduction in the number of juvenile oocytes by acute killing was responsible for this shortened reproductive life. The present study indicated again that the sensitivity of the oocytes to the lethal effects of X-rays is unquestionably meiotic stage-dependent.View full abstractDownload PDF (253K)
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