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Volume 34 (1993)
- Issue 4 Pages 269-
- Issue 3 Pages 195-
- Issue 2 Pages 141-
- Issue 1 Pages 1-
Volume 34, Issue 4
Displaying 1-4 of 4 articles from this issue
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NAOKI YOSHIDA, HAJIME IMADA, NAOKI KUNUGITA, TOSHIYUKI NORIMURA1993 Volume 34 Issue 4 Pages 269-276
Published: December 15, 1993
Released on J-STAGE: May 24, 2006
JOURNAL FREE ACCESSInduction of an adaptive survival response in 1360171 mice exposed to whole-body irradiation by low doses of X-rays (priming exposure) then to high doses of X-rays (challenge exposure) was examined. The adaptive survival response was determined by comparing the cloning efficiency of low dose-irradiated spleen T-lymphocytes to that of unprimed controls. Maximal expression of the adaptive survival response induced by exposure to low doses of X-rays occurred 7 hours after the priming exposure. The optimal low dose range for the induction of the adaptive survival response was 0.05-0.1 Gy. Thus, low dose X-irradiation induces the adaptive response in spleen T-lymphocytes of B6C3F1 mice as assessed by survival. The duration of this response is short, and there is an optimal low dose range. The Dq value for the primed cells was somewhat larger than that for the unprimed ones. Low dose exposure may enhance the capacity of spleen cells for repair during priming.View full abstractDownload PDF (305K) -
LAKSHMI SARMA, ASHU B. TIKU, P. C. KESAVAN, M. OGAKI1993 Volume 34 Issue 4 Pages 277-284
Published: December 15, 1993
Released on J-STAGE: May 24, 2006
JOURNAL FREE ACCESSThe possible role of orally fed Chlorella vulgaris (E-25) in modulating the gamma-ray induced chromosomal damage in whole-body irradiated mice was evaluated using a micronucleus test. Different doses of E-25 were administered either chronically (once, twice or thrice a day for 28 days) or as single acute doses before/after irradiation. A significant radioprotective effect was observed in both acute and chronic pretreatments, but only at doses above 400 mg/kg body weight. However, in mice that received E-25 (500 mg/ kg) three times a day for 28 days, there was no protective effect, and a significant loss in their body weight was observed. Interestingly, E-25 afforded significant radioprotection even when it was administered within 0.4 hr after irradiation.View full abstractDownload PDF (321K) -
HISAKO SAKIYAMA, MIEKO YASUKAWA, MASAHIRO NISHIJIMA, EIKO WADA, SHIRO ...1993 Volume 34 Issue 4 Pages 285-293
Published: December 15, 1993
Released on J-STAGE: May 24, 2006
JOURNAL FREE ACCESSX-ray induced neoplastic transformation of C3H/10T1/2 cells was suppressed equally by Lipid A and LPS. We examined the effects of several modifiers of arachidonic acid (AA) metabolism in our investigation on the suppression mechanism of LPS. Dexamethasone (DM), an inhibitor of phospholipase A2 (PLA2), abolished the effect of LPS, whereas bromophenacyl bromide (BPB), another inhibitor of PLA2 did not. AA and aspirin neither changed the transformation frequency nor blocked the effect of LPS. TPA, 12-O-tetradecanoyl-phorbol-13-acetate, slightly enhanced radiation transformation, which was diminished by LPS. We also examined the effects of these modifiers on the release of radioactivity from 3H-AA-labeled 10T1/2 cells. No definite correlation was found between the change of AA metabolism and suppression of the transformation frequency by LPS. LPS, however, enhanced dose-dependent myristoylation of the 22 and 67 kDa proteins of 1OT1/2 cells.View full abstractDownload PDF (397K) -
MANJU LATA GUPTA, A. GHOSE1993 Volume 34 Issue 4 Pages 295-301
Published: December 15, 1993
Released on J-STAGE: May 24, 2006
JOURNAL FREE ACCESSRadioprotective effectiveness of a combination of HT and AET was evaluated by radiation induced micronucleus screening in mouse bone marrow. Swiss albino mice were injected with 2-Aminoethylisothiouronium bromide hydrobromide (AET) + 5-hydroxy-L-tryptophan (HT) 30 minutes prior to a single whole body exposure of 8 and 12 Gy Co60 gamma rays. Animals were sacrificed at different intervals viz., 24 hours, 40 hours, 72 hours and 7 days after irradiation. Slides of femur marrow were screened thoroughly for cells with micronuclei. Marked decreases in the frequency of micronuclei in irradiated mice receiving radioprotector suggested that the combination has rendered protection to bone marrow cells against 8 Gy and 12 Gy whole body gamma irradiation. Micronucleated cells count is not altered by administration of the combination alone.View full abstractDownload PDF (263K)
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