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Volume 12, Issue 2
Displaying 1-5 of 5 articles from this issue
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Hisao YAMASHITA, Jotaro OKURA, Koichi IZUMI1971 Volume 12 Issue 2 Pages 41-50
Published: 1971
Released on J-STAGE: August 29, 2006
JOURNAL FREE ACCESSAdrenochrome monoguanylhydrozone methansulfonate (S-Adchnon) has the highest solubility in water among adrenochrome derivatives. From the action of S-Adchnon against capillaries, protective effect against radiation-induced damages of hematopoietic organs is to be considered. A dose of 100-300 mg of S-Adchnon was given 15-30 minutes before every expected irradiation by single intravenous injection, or it was administered in divided doses orally during the course of radiation therapy of cancer patients. A total of 150 cases treated by S-Adchnon were compared with 100 control cases receiving no protective agent. Variation of erythrocyte counts and hemoglobin contents was less than 5 in either S-Adchnon cases or control cases. The mean rate of reduction of leucocyte counts was 22±4 % in S-Adchnon-administered cases compared with 30±4 % in control cases indicating considerable effect of the drug. The mean rate of reduction of thrombocyte counts was 27±3 % in S-Adchnon administered cases and 40±9 % in control cases. This difference was also statistically significant. S-Adchnon was considered as one of the effective agent to reduce the side effect of radiation therapy on hematopoietic organ.View full abstractDownload PDF (385K) -
Jacob EAPEN, N. NARAYANAN1971 Volume 12 Issue 2 Pages 51-55
Published: 1971
Released on J-STAGE: August 29, 2006
JOURNAL FREE ACCESSA study on the gross distribution of 137Cs in pigeon tissues showed that initially cardiac muscle acquired the maximum amount of the radionuclide followed by pancreas, liver, gizzard, red muscle and white muscle in that order. Over a period of time white muscle showed more radioactivity than the other tissues because it accumulated 137Cs steadily and lost the radionuclide more slowly. Among the subcellular fractions, the supernatant had 65-80 %, nuclear fraction 12-21 %, mitochondria 1.1-10 % and microsomes 0.45-3.4 % radioactivity indicating that the major portion of 137Cs in cells occurs in soluble form.View full abstractDownload PDF (214K) -
N. NARAYANAN, Jacob EAPEN1971 Volume 12 Issue 2 Pages 56-60
Published: 1971
Released on J-STAGE: August 29, 2006
JOURNAL FREE ACCESSThe in vivo effects of malonate, succinate and glucose on 137Cs uptake by muscles of pigeon have been studied. At 15 pg malonate/g body the radionuclide uptake in red muscle, white muscle, cardiac muscle and smooth muscle was found to be reduced by 27%, 14%, 23% and 27% respectively in comparison to the controls. The inhibition of radiocesium uptake has been even more pronounced at 25μg malonate/g body with as much as 68 % reduction of uptake in red muscle. Succinate and glucose enhanced the uptake of 137Cs in varying degrees in all the muscles. Moreover, both succinate and glucose could overcome the inhibitory effect of malonate in all the tissues except smooth muscle.View full abstractDownload PDF (200K) -
Toyozo TERASIMA, Yoshisada FUJIWARA, Mieko YASUKAWA, Sachiko TANAKA1971 Volume 12 Issue 2 Pages 61-72
Published: 1971
Released on J-STAGE: August 29, 2006
JOURNAL FREE ACCESSBy the use of synchronous mouse L cells, survival response to Xrays was determined throughout the cell cycle. The pattern of a single dose survival was essentially the same as found for HeLa cells previously, i.e., most sensitive at mitosis and the Gl-S transition phase ; most resistant at the early G1 and intermediately resistant at the late S phase. The survival parameters, extrapolation number (n) and mean lethal dose (Do), underwent the similar change during the cell cycle. Difference in sensitivity between early G1 and G1-S transition phase was a factor of 3 in terms of n value, roughly 1.4 in Do value.
The development of resistance during the S phase was suppressed, although not entirely, by the introduction of hydroxyurea, an inhibitor of DNA synthesis. The finding suggests that the sensitivity during the S phase is strongly related to the DNA synthesis.
The survival curve of L cells, either randomly or synchronously growing, exhibited an increasing curvature with radiation dose. However, the frequent renewals of growth medium improved only survivals to more than 900 rads. Several possibilities for such anomalous inactivation were discussed on the basis of medium renewal experiments.View full abstractDownload PDF (532K) -
Akihiro SHIRAGAI1971 Volume 12 Issue 2 Pages 73-86
Published: 1971
Released on J-STAGE: August 29, 2006
JOURNAL FREE ACCESSIt was attempted to estimate the absorbed doses in cell after incorporation of tritium with the constant absorption model. The point source dose distribution, the dose distributions due to tritium locally incorporated, the fraction of self-absorption in spherical source and the fraction absorbed in sphere of energy emitted from the source around the sphere could be analytically calculated with the constant absorption model, where the beta-spectrum was divided into eighteen one-keV intervals and the beta-particles were supposed to have the middle energy in each energy group.
Furthermore the results were compared with the other ones and the questionable points contained in these estimation methods investigated. Then it was pointed out that the stopping power and the transmission probability of low-energy electrons would be required to be established theoretically and experimentally.View full abstractDownload PDF (472K)
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