巻号一覧
1 巻, 1 号
選択された号の論文の4件中1～4を表示しています
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Yoshio MONMA, Hideya SAITO, Tsuneyoshi TANABE1976 年 1 巻 1 号 p. 20-25
発行日: 1976/01/15
公開日: 2008/02/21
ジャーナル フリーBy using the polarographic technique with a rotating electrode, respiratory function was tested in heart mitochondria which were obtained from guinea pigs pretreated with sympathomimetics and adrenergic blocking agents. The degree and duration of mitochondrial impairment were dose-dependent. Alpha and beta adrenergic blocking agents both induced the same type of obstruction of mitochondrial respiration as was seen with sympathomimetics. It has been suggested that a hypoxic state of the myocardium induced by sympathomimetics is partially related to the onset of respiratory obstrution in myocardial mitochondria. No relationship was observed between the catecholamine-induced impairment of mitochondria and adrenergic receptors in the myocardium.抄録全体を表示PDF形式でダウンロード (630K) -
Masahiko TAKADA1976 年 1 巻 1 号 p. 26-31
発行日: 1976/01/15
公開日: 2008/02/21
ジャーナル フリーDetoxication of bis (2-hydroxy-3, 5-dichlorophenyl) sulfide, bithionol, was investigated in man. A novel metabolite was isolated as a crystalline derivative from bithionol medicated urine and identified as bithionol-monoglucuronide (as a methyl acetyl derivative). Oxidation of the sulfur atom of this compound was not recognized It is concluded that bithionol is detoxicated partially by forming a monoglucuronide conjugate.抄録全体を表示PDF形式でダウンロード (551K) -
Yutaka KASUYA, Hiroshi MIYATA, Minoru WATANABE1976 年 1 巻 1 号 p. 32-38
発行日: 1976/01/15
公開日: 2008/02/21
ジャーナル フリーUsing whole body- and micro-radioautography it was found that radio-activity was specifically retained for more than a month following an i.v. injection of 14C-chloroquine in the retinal pigment epithelium of pigmented rats and guinea-pigs, but not in that of albino animals. By a long term oral administration of chloroquine the intensive accumulation of melanin granules in the pigment epithelium and also in the choroid of the pigmented guinea-pig was observed. Using synthetic melanin, chloroquine was found to be adsorbed by melanin in two modes; one operates in low chloroquine concentrations and is extremely strong and independent to pH, and the other operates in higher chloroquine concentrations and is pH-dependent and chloroquine can be released by washing.抄録全体を表示PDF形式でダウンロード (1321K) -
真板 敬三, 増田 裕, 鈴木 善雄1976 年 1 巻 1 号 p. 39-49
発行日: 1976/01/15
公開日: 2008/02/21
ジャーナル フリーSanpoly-305を飼料中に100ppm, 1,000ppm, 2,500ppmの濃度で混入させ, 79週間ラットに投与した。動物は, 52週頃まではネズミ肺炎による一般状態悪化を除き, 著変を示さなかった。52週以降, 眼ヤニ, 動作緩慢等いわゆる老令ラットが示す症状を呈したが, 薬剤投与による特異的変化はなかった。体重, 摂餌量, 血液, 臨床化学的検査, および尿検査に対照と差はなかった。病理組織学的検査にも, この系統の同年令のラットが示す変化と異なる病変はなかった。腫瘍発生数とその種類には, 薬剤投与による特異的影響は見出せなかった。抄録全体を表示PDF形式でダウンロード (1126K)
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