巻号一覧
3 巻, 2 号
選択された号の論文の7件中1～7を表示しています
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Tadashi ASO, Yasushi ABIKO1978 年 3 巻 2 号 p. 109-115
発行日: 1978/05/15
公開日: 2008/02/21
ジャーナル フリーIn control rats, the arsenic level in the spleen and blood cells was 1.59 and 10.79 μg/g wet tissue, respectively. In the kidney, lung, heart, brain, and hair, the arsenic level was lower than 1.1 μg/g wet tissue. In rats in which a pellet containing 2mg of arsenic tsioxide was implanted subcutaneously, the arsenic level in the spleen and blood cells was markedly high for at least 2 months after implantation; after 67 days of implantation, the arsenic level in the spleen and blood cells was 16.79 and 66.34 μg/g wet tissue, respectively. In the kidney, liver, lung, heart, brain, and hair, the increase in arsenic after implantation was smaller than that in the spleen. In the plasma, arsenic was not detected before and after arsenic implantation. It is concluded that arsenic implanted subcutaneously concentrates in the blood cells, possibly in the red cells, In rats.抄録全体を表示PDF形式でダウンロード (547K) -
宗岡 洋二郎, 柴 芳樹, 前谷 照男, 菅野 義信1978 年 3 巻 2 号 p. 117-126
発行日: 1978/05/15
公開日: 2008/02/21
ジャーナル フリーThe effect of mersalyl on the relaxation of catch by various monoamines was studied in the anterior byssal retractor muscle of Mytilus. As has already been reported, mersalyl blocked the relaxing response to indoleamines but not block that to catecholamines. The relaxations in response to catecho-amine-related compounds (dopa, octopamine, tyramine, phenylephrine, β-phenyl-ethylamine and phenylethanolamine) and hexylamine were, however, antagonized more or less effectively with mersalyl. It was suggested that the catecholamine-related compounds and hexylamine can act on relaxing nerve endings to increase neurotransmitter serotonin in the junctional clefts, and mersalyl antagonizes the relaxation in response to these compounds by blocking the serotonin.抄録全体を表示PDF形式でダウンロード (820K) -
A STUDY ON THE TOXICITY OF NATURAL FOOD DYES : TOXICITY AND ENZYME INHIBITION IN PARAMECIUM CAUDATUMFumiyo SAKO, Noriko KOBAYASHI, Naoyuki TANIGUCHI, Eimatsu TAKAKUWA1978 年 3 巻 2 号 p. 127-136
発行日: 1978/05/15
公開日: 2008/02/21
ジャーナル フリーThe toxicity of 14 commercial natural dyes which are widely used as food additives in Japan was studied on Paramecium caudatum. Laccaic acid and capsanthin were found to be very toxic to Paramecium caudatum. Some of the commercially available carminic acid and crocin were also toxic. The inhibitory effect of natural food dyes on leucine aminopeptidase, acid phosphatase and esterase in vitro was proportional to the toxic effect of the dyes on the survival time of Paramecium caudatum. Analyses of the commercial natural food dyes by high performance liquid chromatography failed to identify the toxic components.抄録全体を表示PDF形式でダウンロード (716K) -
Akiko KASAMAKI, Koji FURUYA, Masatsugu KANAMITSU1978 年 3 巻 2 号 p. 137-146
発行日: 1978/05/15
公開日: 2008/02/21
ジャーナル フリーAntibody to clioquinol (5-chloro-7-iodo-8-hydroxyquinoline: CIHQ) was detected by passive hemagglutinating reaction in rabbits receiving a prolonged administration of Emaform which was once a commercial preparation of CIHQ. The antibody was shown to be in the immunoglobulin fractions by separation with a specific immunoadsorbent, and it had relatively broad antigenic specificity. The antibody was also demonstrated in sera from patients who suffered from Subacute Myelo-Optico-Neuropathy (SMON) and from normal healthy individuals. However, its titer and frequency of positive reactors in the former were higher than those in the latter, and the two groups could be differentiated each other in frequency distribution patterns of the antibody proprietors. From these results, we discussed on desirable application of sero-epidemiological study to assessment of effects of chemical pollutants on living systems.抄録全体を表示PDF形式でダウンロード (760K) -
Tadanobu ITOH1978 年 3 巻 2 号 p. 147-152
発行日: 1978/05/15
公開日: 2008/02/21
ジャーナル フリーThe dose-related response of the mammary growth was studied in immature ICR-JCL female mice given 0.03 μg of estradiol per animal subcutaneously, and 0.005-1.0 mg of either of the following phenothiazines (chlorpromazine, levometh iomeprazine, promethazine, perphenazine, thioridazine and propericiazine) per 10g of body weight was given orally once a day for 9 days starting on the 5th day after ovariectomy. The right second mamma of the chest was used to compare the hypertrophic effects. All the phenothiazines used produced mammary growth in the intensity sequence of thioridazine > chlorpromazine > promethazine > propericiazine > perphenazine > levomethiomeprazine. An optimal dose of each of the phenothiazines required to produce the maximum hypetrophy of the mammary gland was examined. From the results obtained, the relationship between the side-chain moiety of the compounds and the mammary growth activity could not be revealed.抄録全体を表示PDF形式でダウンロード (593K) -
Naoki SUGAWARA1978 年 3 巻 2 号 p. 153-162
発行日: 1978/05/15
公開日: 2008/02/21
ジャーナル フリーCadmium in the liver and kidney increased with the dosage of this injection. There was a parallel relation between the increase of cadmium in the whole liver and that in the metallothionein. In the liver and kidney, zinc highly increased in the low dose group than in the high dose group. In the 5.0mg/kg group, zinc in the liver was not different from that of the control group, and about 30% of zinc in the 30, 000 g supernatant existed in the metallothionein. By the DEAE-cellulose chromatography of metallothionein, two forms of metallothionein were obtained.抄録全体を表示PDF形式でダウンロード (718K) -
飯田 晶敏, 松永 義正, 松岡 信男, 安部 まさ子, 大西 久美雄, 辰巳 熙1978 年 3 巻 2 号 p. 163-192
発行日: 1978/05/15
公開日: 2008/02/21
ジャーナル フリータマリンド種子多糖類 (グリロイド) を4,8およぴ12%宛飼料に混ぜて2年間にわたり, SD系ラット雌雄に投与し, その長期毒性を検討した。一般状態, 死亡動物数, 体重の変化, 摂餌量, 尿および血液の生化学的検査, 血液学的検査, 臓器重量, 病理学的検査のいずれにもグリロイド投与による毒性所見は見出し得なかった。病理組織学的に加令に伴う変化として, Controlを含む各群で心筋の障害, 慢性の腎障害, 乳腺の腫瘍(雌), 下垂体の腫瘍が多発し, 死亡獣の死因として大きな比重を占めた。その他動脈周囲炎, osteopathy (線維性骨炎) などがみられた。しかし, これらの病変の性質, 発生率などはすべてSD系ラットに通常みられる範囲のものであった。加令に伴って尿蛋白値の上昇がみられ, この尿蛋白値は腎の病理組織学的所見の程度と相関性を示した。抄録全体を表示PDF形式でダウンロード (5329K)
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