The objective of this study was to understand aging-related changes in bone metabolism in men and women based on bone formation/resorption balance, and bone metabolic turnover level, using the levels of bone remodeling markers. This information will allow us to investigate the mechanisms involved in the regulation of bone metabolism. For this study, we selected 55 male and female participants. To evaluate bone turnover parameters, the serum concentration of bone alkaline phosphatase (BAP), a bone formation marker, and tartrate-resistant acid phosphatase (TRACP-5b), a bone resorption marker, were measured; bone density was determined using ultrasound imaging. The levels of bone metabolism markers were used to calculate the correlation between bone formation/resorption, as well as bone metabolic turnover level, and the data were analyzed according to sex and age of participants. As a result, a negative correlation between age and bone density was observed in both male and female participants. To evaluate bone metabolism, all data were separated into four quadrants — (I) fast formation, (II) fast resorption, (III) slow resorption, and (IV) slow formation — and analyzed. Our results showed that, in their 21 to 39 age group, both male and female participants were distributed in the “slow formation” group. In their 40 to 54 age group, male participants were in a so-called “equilibrium state”, while female participants were primarily distributed in the “fast resorption” group, suggesting age-related changes in bone metabolism.
View full abstract