The clinical application of ruby laser is expected because of the great power density-and short pulse time of it. Now considerable amount of basic studies for clinical use is do-ing with organs and tissues of many kinds of experimental animals. However literature deal-ing with peripheral nerve has been unknown except only one report by Högberg, et al.
In this paper, effects of ruby laser with a power density of 10
5-10
7 watts/cm
2 on isolated sciatic nerves of bullfrogs and giant axons of crayfishes were studied. The results. obtained were as follows.
1) Both non-treated sciatic nerves and giant axons were not excited by stimulating, directly these with ruby laser of any output.
2) In peripheral nerves treated with green vinyl tape (complementary color of ruby laser light) on these surfaces, giant axons showed an exciation with laser energy of more than 0.7 joules. Sciatic nerves were not still excited.
3) In sciatic nerves, 2-5 pulses (a pulse: 7.9 J, 2×10
7 watts/cm
2) caused a reduction of action potential amplitude. 7-20 pulses caused a complete block of action potential pro pergation.
4) The main microscopic findings showed demyelinization and vacuolation in the-myelin sheath.
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