In this study, we examined the relationship of 24-hour ambulatory blood pressure (24-hABP) and pulse pressure to urinary total protein mg/g Creatinine ratio (TPmg/gCRE) and urinary albumin mg/g Creatinine ratio (ALBmg/gCRE) . We examined 222 community-based elderly Japanese people aged 71.0±10.8 years, who participated in a medical examination given in the Tsukuba district, and classified these patients into two groups according to the presence or absence of antihypertensive medications.
We carried out X² test on each of the two groups because we examined whether hypertension was related to urinary albumin excretion. Under all conditions, we recognized significant differences. Therefore, we categorized them as having normoalbuminuria (<30 mg/gCRE), and abnormal albuminuria (≥30 mg/gCRE), based on ALBmg/gCRE. In patients with antihypertensive medications, average systolic blood pressure (SBP) and pulse pressure under all 24-hABP measuring conditions (24-hour, daytime, night time and casual time) was significantly higher in patients with abnormal albuminuria than in patients with normoalbuminuria. However, in patients without antihypertensive medications, average 24-hour, night time and casual time SBP was significantly higher in patients with abnormal albuminuria than in patients with normoalbuminuria, pulse pressure did not differ significantly between the two groups under any condition.
Moreover, univariate regression analysis showed a close relationship between 24-hABP and TPmg/gCRE and ALBmg/gCRE. In patients without antihypertensive medications, both TPmg/gCRE and ALBmg/gCRE correlated significantly with SBP and pulse pressure under all 24-hABP mesuring conditions. However in patients with antihypertensive medications, ALBmg/gCRE correlated significantly with SBP and pulse pressure under all 24-hABP mesuring conditions, TPmg/gCRE correlated significantly only with nighttime pulse pressure.
Therefore, we recognized that in elderly Japanese people, SBP and pulse pressure played significant roles as determining factors of albuminuria.
We also studied the usefulness of antihypertensive medications by examining the effect of antihypertensive medications on TPmg/gCRE and ALBmg/gCRE and subcategorized these patients as having hypertension (24-hour SBP≥135 mmHg or 24-hour DBP≥85 mmHg), or normotension in each group according to the presence or absence of antihypertensive medications. Average TPmg/gCRE and ALBmg/gCRE were significantly lower in normotensive patients with antihypertensive medications than in hypertensive patients without antihypertensive medications.
Thus, it was suggested that by maintaining the blood pressure below the standardized level with antihypertensive medications, renal disorder with hypertension could be avoided. Therefore, we thought that the antihypertensive medications were significantly useful in elderly Japanese people with hypertension, and that it was possible to recognize renal disorder as a complication of hypertension in the early stage by regularly measuring TPmg/gCRE and ALBmg/gCRE.

View full abstract

The purpose of this research was to investigate the correlation between prevalence of chronic obstructive pulmonary disease (COPD) and smoking habit in subjects on human dry dock. The subjects were 6, 967 persons (4, 722 males and 2, 245 females ; age : 46.9±8.0 years ; range : 30-73 years) who have human dry dock at 5530 clinic health screening center in 2001. COPD was diagnosed by FEV_1.0% (FEV_1.0/VC×100) ≤70%. The subjects were divided into non-smokers, exsmokers and current smokers based on their smoking habit.
The prevalence of COPD of all subjects was 3.8%, and the prevalence in each group of non-smokers, ex-smokers and current smokers increased significantly over 50 years old compared with corresponding value in 30-39 years old. Particularly, the prevalence in current smokers increased remarkably compared with that in other groups. The prevalence in 50-59 years old and over 60 years old was higher in order of non-smokers, ex-smokers, current smokers of Brinkman index<400, current smokers of Brinkman index≥400. However, the prevalence in the other age groups did not show significant difference among the previous four groups. The percentage of exsmokers increased. And the percentage of current smokers decreased with aging.
These results suggest that the prevalence of COPD increases irrespective of smoking habit in over 50 years old, and that it is higher in persons who have smoking habit with higher Brinkman index. Therefore, we conclude that it is necessary to perform the spirometry for all persons who have medical check-up including human dry dock in order to detect COPD.

View full abstract

Objective of this study was to investigate effects of twice-a-week physical exercises on body fat and aerobic ability of 65 healthy female college students who participated in a 10-week weight loss program. The results showed that skin fold thickness of both scapula and upper arm were significantly reduced after exercise relative to the basal levels, together with significant decrease in body fat rate after exercises compared with the base line values. Heart rates 1, 2 and 3 min. after completion of the step test also revealed significantly lower rates after the periodic exercises compared with those without exercises. Before commencement of the exercise, significant correlation was evidenced between body fat rates and heart rates 1, 2 and 3 min. after the step test ; after the exercise, however, no correlation was observed between body fat rates and heart rates 1, 2 and 3 min. after the step test.
These results demonstrated that periodic twice-a-week physical exercises contributed to both decrease in body fat and elevation of aerobic ability, indicating that periodic physical exercises would play an important role in alleviation of obesity.

View full abstract

By the storage of the continual medical examination data, the setting of the individual referense value is the essence in pathopoiesis and primary prevention for critical prevention.
Generally, naturally in the healthy subject, individual reference value is small, if it is compared with reference value of the group, and it is expected that the prediction of the crisis becomes possible by having individual seeking diagnosis result in the reference intervales.
By having observation-required person to AMHTS (health screening) and next time medical examination, it is positive seeking diagnosis from the person, there starts it the fruit of the follow-up can be raised, and it is a place of the AMHTS proprietor which fears filling suit of“malpractice”by another temple seeking diagnosis of the disease which the stage was hidden this time by“mistake”most.
Then the development of device and system that it does“the self blood collection (Self-medication) immediately, when the medical examinee learned consciousness of disease or abnormality, and that family doctor of the congratulations facilities intends to grasp the measurement result by mail of the specimen is reported, because it was undertaken.

View full abstract