Changes of levels of serum lipids have been investigated on the condition of taking eggs and milk including their products for persons with hypercholesterolemia. In this study the levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were compared at the annual health checks (ningen dock) of the previous year and of the current year. 289 subjects were divided into three groups, Group A of 175 subjects who took eggs and milk usually, Group B of 53 subjects who stopped to take them and Group C of 61 subjects who did not take them as usual. In Group A, levels of TC, TG, HDL-C and LDL-C changed 250±23 mg/dl to 253±31 mg/dl, 140±95 mg/dl to 143 ± 114 mg/dl, 65 ± 16 mg/dl to 67±18 mg/dl, and 158±26 mg/dl to 160±29 mg/dl respectively. In Group B, 262±31 mg/dl to 230±23 mg/dl, 132±64 mg/dl to 131±72 mg/dl, 69±17 mg/dl to 65±15 mg/dl and 165±30 mg/dl to 139±19 mg/dl respectively. In Group C, 255±22 mg/dl to 253±30 mg/dl, 167±130 mg/dl to 166±98 mg/dl, 64± 18 mg/dl to 64± 17 mg/dl and 162±24 mg/dl to 159±31 mg/dl respectively. Levels of TC, HDL-C and LDL-C in Group B decreased significantly after stopping to take eggs and milk by 32±25 mg/dl (12%), 4±8 mg/dl (6%) and 26±26 mg/dl (16%) respectively. Also there were a linear correlation between TC and LDL-C levels (y=0.7159x-21.842, r=0.522) and an exponential correlation between TG and HDL-C levels (y=203.74x-0.2415, r=0.2741) .
The aim of this study was to discover ways to improve the functionality of health consultations by occupational physicians. A self-administered questionnaire survey was conducted for 497 workers of a manufacturing plant. A standard partial regression coefficient was computed by multiple linear regression analysis, with the workers' perceived helpfulness of health consultations by occupational physicians as the dependent variable, and the basic attributes of subjects, occupational physicians' dedication, overtime hours, fatigue accumulation, and privacy protection as independent variables. Workers who felt that occupational physicians were dedicated and privacy protection was observed tended to feel that health consultations by occupational physicians were helpful. Blue-collar workers and workers without a family physician also felt that health consultations by occupational physicians were helpful. For health consultations by occupational physicians to work effectively, it is necessary to help workers realize the occupational physicians' dedication and to convey to the workers the absolute assurance of their privacy protection. It is also necessary to convey the importance of providing health consultations by occupational physicians for blue-collar workers and workers without a family physician.
Current health promotion is based on average evaluations obtained from statistics of large populations but, in reality, the range of 2SD (standard deviation) may not cover medical and nutritional requirements owing to genetic polymorphisms among healthy individuals. Thus, nutrigenomics in human energy metabolism is needed for personalized health promotion based on individual genetic evaluation of single nucleotide polymorphisms (SNPs) etc. Energy metabolism depends on thrifty genes including SNPs of transporters (uncoupling proteins etc.) and receptors (adrenergic receptors etc.) . The impact of Westernization on both nutrition and thrifty genes of Japanese has caused a rapid increase in metabolic syndrome. In health promotion, personality is also important in behavioral change; most Japanese have the obedient S/S genotype of the serotonin transporter gene, and careful instruction is needed in health promotion. Our personalized health promotion program reversed metabolic syndrome, not only in the short-term (11 months), but also in the long-term (average, 23 years) irrespective of the presence of thrifty genes. However, the rapid increase in metabolic syndrome will need more advanced omics of adipose tissue, including those of prohibitin and resveratrol. The prevention of final disability resulting from cardiovascular diseases and dementia is important. In addition to thrifty genes, we should consider methylene tetrahydrofolate reductase SNP in C677T. To prevent hyperhomocysteinemia, improvement of serum folate was easier when genome information was given to examinees.