The Japanese Journal of Physiology
Print ISSN : 0021-521X
12 巻, 3 号
選択された号の論文の11件中1~11を表示しています
  • 川村 浩, 大島 清
    1962 年 12 巻 3 号 p. 225-233
    発行日: 1962年
    公開日: 2011/06/07
    ジャーナル フリー
  • 伊藤 真次
    1962 年 12 巻 3 号 p. 234-241
    発行日: 1962年
    公開日: 2011/06/07
    ジャーナル フリー
    1. ACTH activity of anterior and posterior lobe extracts obtained from adult male rats was determined by the in vitro method of SAFFRAN and SCHALLY and by the method of SAYERS et al.
    2. In case ACTH activity was measured by the in vitro method, the activity of the anterior lobe was 1242±101mU per gland and 283±21.0mU per mg fresh tissue, and that of the posterior lobe 53±4.8mU per gland and 88±7.6mU per mg.
    3. Markedly less activity was obtained by the method of SAYERS: 1mU standard ACTH activity was equivalent to 10.7mU anterior lobe extract and 7.6 mU posterior lobe extract as determined by the in vitro method.
    4. Pitressin in doses used in the present experiments had no effect on rat adrenal tissue in vitro in releasing corticosterone, nor potentiating the activity of ACTH added together. Pitressin did not cause any depletion in adrenal ascorbic acid concentration in hypophysectomized rats, nor potentiate ACTH activity of the anterior lobe extract.
    5. Brain extracts did not show any ACTH activity in vitro.
  • 小林 惇, 入沢 宏
    1962 年 12 巻 3 号 p. 242-250
    発行日: 1962年
    公開日: 2011/06/07
    ジャーナル フリー
    In oyster myocardium, the latent period of relaxation is much longer than that of contraction, namely the mean value of the former is 311 msec and that of the latter is 88 msec at 15-18°C. This appears to show that the mechanisms of relaxation and of contraction are different from each other. The latent period of relaxation remains within a fairly constant range irrespective of the intensity and the duration of stimulus or muscle tension. Moreover, it does not show any recognizable change in the administration of metabolic inhibitors or narcotics. Only the change in temperature of the external fluid has a remarkable positive effect on the latent period of relaxation. The temperature coefficient (Q10) is about 2. This result suggests that the latent period of relaxation has some relations to chemical processes.
  • 勝沼 晴雄, 小泉 明
    1962 年 12 巻 3 号 p. 251-256
    発行日: 1962年
    公開日: 2011/06/07
    ジャーナル フリー
    Individual differences in total leucocyte counts are analyzed on twelve heathly adult males and industrial workers exposed to hazardous organic solvents. It has become clear that there exists marked individual difference in the distribution of total leucocyte count, and each individual shows its own pattern variation;therefore it should be emphasized that the evaluation of “normal” or “abnormal” in physiological measurement is to be done very carefully.
  • 伊藤 真次
    1962 年 12 巻 3 号 p. 257-261
    発行日: 1962年
    公開日: 2011/06/07
    ジャーナル フリー
    ACTH content in the anterior pituitary lobe is diminished after administration of hypertonic saline, injection of Pitressin and exposure to severe heat, whereas ACTH content in the posterior lobe was not altered by these treatments. Water deprivation as well as starvation caused a marked reduction in the ACTH content in both lobes of the pituitary gland.
  • 堀田 利夫, 竹中 敏文
    1962 年 12 巻 3 号 p. 262-271
    発行日: 1962年
    公開日: 2011/06/07
    ジャーナル フリー
    Interaction between responses elicited in the somatosensory cerebral cortex, following single shock stimulation of the visual cerebral area and the superficial radial nerve or the contralateral somatosensory area, was studied in cats anesthetized with chloralose and immobilized with Faxedil. The range of latencies of discharges for the initial spikes from stimulation of the primary visual cortex varied from 8 to 30msec in the somatosensory cortex. Spike discharges, recorded from a single cortical neuron, were reciprocally interacted by a conditioning-testing procedure and were blocked by a preceding response in some neurons; in other neurons, temporal summation was shown.The depressive effect following the first stimulus was found often to last more than 100 msec. Blocking of spike discharges following stimulation of the visual cortex was produced by the hyperpolarized afterpotential in the response elicited from stimulation of the sensory nerve. These results suggest that associative volleys from another cortical area modify activity of the somatosensory cortical neuron as depression or temporal summation.
  • James C. BOUDREAU
    1962 年 12 巻 3 号 p. 272-278
    発行日: 1962年
    公開日: 2011/06/07
    ジャーナル フリー
    Olfactory tract activity was recorded in curarized catfish.Stimuli were administered with a continuous flow technique. Marked changes in tract activity occured to onset and cessation of flow. Mechanical stimulation consistently produced a large spike discharge. Increases in tract activity were produced by a large variety of substances dissolved in water. Many chemicals were effective stimuli when presented in extremely dilute concentration. The magnitude of the tract response increased with an increase in odor concentration over a wide range of dilution. High concentrations of certain odors depressed tract activity.
  • 深見 安
    1962 年 12 巻 3 号 p. 279-292
    発行日: 1962年
    公開日: 2011/06/07
    ジャーナル フリー
    1. Using single intracellular micropipettes in a bridge circuit, anodal break response of motoneurons was explored in unanaesthetized toad's spinal cord in situ.
    2. Some motoneurons showed anodal break response to relatively weak current, while in others it was hardly elicitable even with much stronger current unless the membrane had previously been depolarized by subthreshold current.
    3. The firing level of anodal break response was in general either near the original membrane potential or on slightly depolarized side of it and remained constant irrespective of the varying intensities of current. The latency of the response was either independent of current intensity or it became longer with increase in the current strength.
    4. The relationship between current strength and its duration was found to follow approximately the “exponential law”. HILL'S constant of accommodation was calculated from the strength-duration curve in three cases and found to be 17.3, 31.7 and 43.3 msec.
    5. In one and the same motoneuron, the break response was initiated from the same site, initial segment or soma, as the make response. In some motoneurons, the break response was originated from the first node of myelinated axon.
    6. The results obtained with exponentially decaying current indicated that IPSPs, when elicited in more or less depolarized motoneurons, would be capable of initiating impulses by removing the accommodative process developed in a motoneuron, and would thus maintain cellular activities.
  • 尾関 正寛
    1962 年 12 巻 3 号 p. 293-311
    発行日: 1962年
    公開日: 2011/06/07
    ジャーナル フリー
    1. The relationship between mechanical and electrical activities of the snail retractor pharynx muscles has been studied.
    2. The magnitude of mechanical and electrical responses became larger with an increase in stimulus intensity, and the electrical responses have a linear relationship with the logarithm of tension developed. When the muscle was stimulated indirectly or directly, two different lines between these two responses were observed (FIG. 6).
    3. There is clear evidence of facilitation of the muscle contraction by indirect and direct stimulation after a conditioning stimulus. The interval of two stimuli to produce maximum facilitation is about 20-60 msec.
    4. The n. j. p.s were summed and potentiated by repetitive indirect stimuli and these reached a maximum at a frequency of 50/sec.
    5. The maximum contractions are produced by repetitive stimuli of 50/sec (indirect stimulation) and 30-50/sec (direct stimulation).
  • 中浜 博, 斎藤 幹夫, 荒井 雪江
    1962 年 12 巻 3 号 p. 312-323
    発行日: 1962年
    公開日: 2011/06/07
    ジャーナル フリー
    Facilitation of cervicothoracic motoneuron populations of cat was observed when a single shock was delivered to the anterior and the posterior region of somatic area I and somatic area II following a conditioning shock to the contraand ipsilateral superficial radial and saphenous nerve. The greater amplitude of the responses was seen at 10-200 msec. stimulus intervals, although the maximal amplitude was recognized at 25-60 msec. The maximal latency shortening of about 3 msec. was seen at 10-25 msec. stimulus intervals, while the latency shortening of about 1 msec. was observed at 2-10 and 25-200 msec. Similar results were obtained even after the medullary pyramidotomy, indicating that the facilitation of cortically induced activities by a preceding cutaneous volley is caused through the extrapyramidal system. The dosages of nembutal required to block the facilitation were smaller in the pyramidotomized preparations than in the intact preparations, suggesting that cortically induced pyramidal activities also play a role to the facilitation.
  • 真島 英信, 松村 幹郎, 中山 雪麿
    1962 年 12 巻 3 号 p. 324-336
    発行日: 1962年
    公開日: 2011/06/07
    ジャーナル フリー
    1. The coupling relation between action potential and mechanical response during repetitive stimulation was investigated using the sartorius muscle of the frog.
    2. The course of decrease in spike height obtained by partition method coincided with that by intracellular recording.
    3. The coupling efficiency between spike height and peak tension during repetitive stimulation was improved at first during staircase phenomenon and then it decreased progressively.
    4. Fatigue, higher stimulating frequency, and heavy load resulted in a deficiency of coupling process, especially the mechano-chemical process.
    5. At higher temperature, the coupling efficiency for single stimulus was decreased, but for repetitive stimulation the period of staircase phenomenon was greatly prolonged and the rate. of decrease in spike height became much slower.
    6. The height of negative after-potential or the spike duration showed a poor correlation with peak tension during repetitive stimulation.
    7. When the muscle was stimulated at 2c/sec through nerve, transmission fatigue was observed in the range beyond 300 stimuli.
    8. The electro-mechanical coupling, as the complex of the activation process for contraction and the energy mobilizing process in contraction, was discussed.
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