ISOKAWA et al.  and KAWAI , using a scanning electron microscope reported that the interglobular spaces in human teeth appeared as small empty cavities in the dentin proper. However, in view of the known process of their formation, it is hardly conceivable that they are empty cavities. There are for instance no spaces when the predentin matrix is formed. It is this matrix which goes on to calcify in a globular manner. Therefore, interglobular spaces could only refer to incomplete calcification of the homogeneous collagen matrix perforated only of course by dentinal tubules and odontoblastic processes. In their study [1, 2] randomly selected tooth specimens were used. These teeth had been placed in formalin immediately after extraction. However, the teeth were not fractured until later so that the scanned subsurface of interglobular space contents had probably not been penetrated and preserved by the fixative.