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Volume 10, Issue 1
Displaying 1-5 of 5 articles from this issue
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Shogo ICHII, Nagasumi YAGO, Shigeru KOBAYASHI, Saburo OMATA1969 Volume 10 Issue 1 Pages 1-7
Published: March 01, 1969
Released on J-STAGE: August 29, 2006
JOURNAL FREE ACCESSAminopyrine N-demethylase activity in rat hepatic microsomes decreased significantly after whole-body X-irradiation of 500 and 650 R. Process of the phenobarbiturate-induction of aminopyrine N-demethylase was found to be inhibited during quite an early period of the induction. Adrenalectomy caused marked decreases in the enzyme activity and cytochrome P-450 content of hepatic microsomes. Physiological significance of these and other metabolic changes was discussed in relation to the lethality of acutely irradiated animals.View full abstractDownload PDF (291K) -
Shigetaka SEKIYAMA, Yuko IWAI, Ziro AMITANI1969 Volume 10 Issue 1 Pages 8-16
Published: March 01, 1969
Released on J-STAGE: August 29, 2006
JOURNAL FREE ACCESSElectron microscopic study on adrenal medullary cells of rats after whole body X-irradiation was made. Adult male rats of the Donryu strain, weighing 150-170g, were irradiated with X-ray (700 R.), and the rats showing a lowering of blood pressure were killed at 72 hours after irradiation. Two types of medullary cells, active and degenerated type, were observed in the irradiated rats. The degenerated cells were more numerous than the active cells, and the former showed mitochondria) swelling, dilated cystic rough-surfaced endoplasmic reticulum and abundant ribosomes. There was found almost complete depletion of catecholamine granules. On the contrary, the active cells had numerous ribosomes, abundant rough-surfaced endoplasmic reticulum, many vacuoles, and exhibited a moderate decrease in number of catecholamine granules. These results suggest that an exhausted condition of medullary cells appeared after hyperfunction due to sympathetic stimulation following whole body X-irradiation and the relationship between lowering blood pressure and degeneration of medullary cells was correlative.View full abstractDownload PDF (1163K) -
Saburo OMATA, Shogo ICHII, Nagasumi YAGO, Shigeru KOBAYASHI1969 Volume 10 Issue 1 Pages 17-24
Published: March 01, 1969
Released on J-STAGE: August 29, 2006
JOURNAL FREE ACCESSRate of the incorporation of 3H-orotic acid into two rapidly labelled RNA fractions, pH 7.6 RNA and pH 8.3 RNA fractions, of liver nuclei was examined in rats received whole-body X-irradiation of 650 R. Rate of the incorporation showed an increase immediately after irradiation, and a decrease during the succeeding four days, and then returned to the control levels. Degree of decrease in the incorporation by X-irradiation was greater in the pH 7.6 RNA fraction than in the pH 8.3 RNA fraction. Sucrose density gradient analysis revealed that there was a minor modification of sedimentation profile of pH 7.6 RNA while no change was detected in pH 8.3 RNA, at one day after X-irradiation. The incorporation of 3H-orotic acid into the acid-soluble fraction of whole liver cells did not change significantly. Free pyrimidine nucleotides in the acidsoluble fraction increased at one day after irradiation. This may explain, at least in part, the decreased rate of the incorporation of 3H-orotic acid into the nuclear RNA fractions at this period.View full abstractDownload PDF (374K) -
Sachiko KAWANO1969 Volume 10 Issue 1 Pages 25-35
Published: March 01, 1969
Released on J-STAGE: August 29, 2006
JOURNAL FREE ACCESSThe relationship of time factors (number of fractions, dose per fraction and intervals between fractions) and the lethal effects on mice was examined by fractionated whole-body irradiation 1) by changing the number of fractions and the dose per fraction with a constant average dose per one day, 2) by changing the dose per fraction with a constant interval between fractions, and 3) by changing the intervals between fractions with a constant dose per fraction.
When a fixed average dose per one day was given, irradiation with a large dose per fraction and small number of fractions was found to be more lethal than that with small dose per fraction and large numbers of fractions.
When the irradiation was given with a constant interval between exposures, the total dose necessary for 50% mortality increased with increasing dose per fraction in a range from 100 R to 600 R.
When the irradiation was given with constant dose per fraction and different intervals between fractions, a decrease in lethal effects was observed with increasing intervals between exposure.View full abstractDownload PDF (405K) -
Kotaro YAMAUCHI1969 Volume 10 Issue 1 Pages 36-44
Published: March 01, 1969
Released on J-STAGE: August 29, 2006
JOURNAL FREE ACCESSDifference spectra of γ-irradiated versus unirradiated solutions of cytochrome-C, of the amino acids constituting cytochrome-C and of aromatic amino acids have been investigated under various conditions. In the neutral solution of cytochrome-C, a broad increase in absorbance over the range from 2350 to 3420 Å with maxima at 2420, 2870 and 2970 Å, and a minimum at 2900 Å was observed. The over-all pattern in the observed difference spectrum of irradiated vs. unirradiated neutral solution of cytochrome-C may be explained in terms of two separate functions: one arises from the conformational change of cytochrome-C and the other comes out of the formation of new chromophore absorbing light around 2970 Å, on which the superimposition of the former is most likely to occur.View full abstractDownload PDF (385K)
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