From estimation of urinary glucuronide by modified Dische's carbazol method, following results were obtained:
(1) When guronsan (D-glucuronolactone) administered in human body or rabbits, it was not utilized directly for conjugation. Because, free glucuronic acid in urine was increased immediately after administration and no conjugated form was excreted.
(2) When menthol was administered to rabbits together with guronsan or glucose, the excreted conjugated glucuronide was found to be much more increasing in case glucose was added.
(3) In experimental study, when sodium salicylate was added to normal group and patients with hepatic disease, there was no difference between them in the amount of conjugated glucuronide in urine, but in case of a few severe hepatic disease excretion level of conjugated glucuronide was much higher than in case of normal or non hepatic disease and considerable time was required to normal level.
(4) In aminal experimental with rabbits similar results were obtained.
抄録全体を表示