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Volume 25, Issue 2
Displaying 1-13 of 13 articles from this issue
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Michio Kato, Keizo Kikkawa, Etsuji Shimada, Yoichi Saitoh1992 Volume 25 Issue 2 Pages 195-202
Published: 1992
Released on J-STAGE: June 08, 2011
JOURNAL FREE ACCESSThe expression of epidermal growth factor receptor (EGFR), which is coded by oncogene erb Bl, and transforming growth factor α (TGF-α) in human gastric cancer were compared with histological findings. The possibility that tumor cell growth is controlled by an autocrine mechanism was also investigated. EGFR was detected by staining frozen sections of gastric cancer by the immuno-histochemical method using anti-EGFR monoclonal antibody and TFG-α by similarly staining paraffin sections with anti-TGF-α polyclonal antibody. The results were compared with histopathological findings. EGFR was positive in 18 of 79 cases (22.8%): 17 of 49 cases of the differentiated type (34.7%) were positive, but only 1 of 30 cases of the undifferentiated type (3.3%). TGF-α was positive in 24 of 86 cases (27.9%): 6 of 48 cases of the differentiated type (12.5%) and 18 of 38 cases of the undifferentiated type (47.4%). Of 36 cases examined for both EGFR and TGF-α, both were positive in 3, all of which were advanced gastric cancer. These results suggest an association between the expression of EGFR and the degree of differentiation of gastric cancer cells. Therefore, it is possible that epidermal growth factor affects the proliferation of the differentiated type of gastric cancer cell. Of the tumor specimens expressing EGFR, some also produced TGF-α. This indicates that some human gastric cancer cells may control their own growth by an autocrine mechanism.View full abstractDownload PDF (16661K) -
Metabolic Changes, Complications, and their ManagementsHarumasa Ohyanagi, Makoto Usami, Hiroshi Kasahara, Hideaki Nomura, Tai ...1992 Volume 25 Issue 2 Pages 203-213
Published: 1992
Released on J-STAGE: June 08, 2011
JOURNAL FREE ACCESSWe investigated the operative results of digestive surgery for the aged from the viewpoint of their perioperative care. During the past 22 years (1969-1990, 3481 patients received operations for esophageal cancer, gastric cancer, hepatic, bilio-pancreatic malignancies, colon cancer, and gallstones, in our department).
The study was divided into two periods as 1969-1979 and 1980-1990, and all the patients were generally classified as the aged and the younger control by the age of 65, especially the patients with TER (thoratic esophageal resection) or PD (pancreatoduodenectomy) were classified by the age of 60, and those with TG (total gastrectomy) were by the age of 70. In each group, the incidence of pre-and post-operative complications, risk age (which is the critical age at which complications are likely to develop), serum parameters for operative stress, post-operative serum proteins, and immunological parameters were studied. Of the 3481 patients, 756 patients were more than 64 years old, accounting for 21.7% of all patients. A comparison of the first and second periods showed that the incidence of the post-operative complications and the post-operative death rate have decreased in the aged (55% vs 49%, 10% vs 3%, respectively). It has become to the elevation of the long-termed survival rate in the digestive surgery. This may be attributable to the improvements of operation methods and anesthesia, and to the remarkable progress in peri-operative managements including nutritional care which can minimize the hormonal and metabolic changes.View full abstractDownload PDF (21042K) -
1992 Volume 25 Issue 2 Pages 277-285
Published: February 01, 1992
Released on J-STAGE: February 17, 2011
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1992 Volume 25 Issue 2 Pages 289-330
Published: February 01, 1992
Released on J-STAGE: February 17, 2011
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1992 Volume 25 Issue 2 Pages 331-370
Published: February 01, 1992
Released on J-STAGE: February 17, 2011
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1992 Volume 25 Issue 2 Pages 373-420
Published: February 01, 1992
Released on J-STAGE: February 17, 2011
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1992 Volume 25 Issue 2 Pages 421-460
Published: February 01, 1992
Released on J-STAGE: February 17, 2011
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1992 Volume 25 Issue 2 Pages 461-500
Published: February 01, 1992
Released on J-STAGE: February 17, 2011
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1992 Volume 25 Issue 2 Pages 501-550
Published: February 01, 1992
Released on J-STAGE: February 17, 2011
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1992 Volume 25 Issue 2 Pages 551-600
Published: February 01, 1992
Released on J-STAGE: February 17, 2011
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1992 Volume 25 Issue 2 Pages 601-650
Published: February 01, 1992
Released on J-STAGE: February 17, 2011
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1992 Volume 25 Issue 2 Pages 651-700
Published: February 01, 1992
Released on J-STAGE: February 17, 2011
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1992 Volume 25 Issue 2 Pages 701-747
Published: February 01, 1992
Released on J-STAGE: February 17, 2011
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