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Volume 36, Issue 2
Displaying 1-6 of 6 articles from this issue
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Jun Haginaka2007 Volume 36 Issue 2 Pages 101-107
Published: April 27, 2007
Released on J-STAGE: November 27, 2012
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Hidetoshi Arakawa2007 Volume 36 Issue 2 Pages 108-115
Published: April 27, 2007
Released on J-STAGE: November 27, 2012
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Hiroshi Ueda2007 Volume 36 Issue 2 Pages 116-124
Published: April 27, 2007
Released on J-STAGE: November 27, 2012
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applications in biomedical analysisYoshinori Kato, Hiroyuki Oyama, Norihiro Kobayashi, Junichi Goto2007 Volume 36 Issue 2 Pages 125-139
Published: April 27, 2007
Released on J-STAGE: November 27, 2012
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Hakuo Takahashi2007 Volume 36 Issue 2 Pages 140-145
Published: April 27, 2007
Released on J-STAGE: November 27, 2012
JOURNAL FREE ACCESSIt has long been thought that atherosclerosis results from passive lipid deposition in the vascular wall. Thus, several methods of anti-cholesterolemic therapy have been conducted. Among them, statin (3-hydroxy-3- methylglutaryl coenzyme A reductase inhibitor) was found to be much superior to the other therapies even when LDL-cholesterol levels were similarly decreased. Therefore, the pleiotripic effects of statins and the underlying mechanisms have been extensively explored. At the downstream of cholesterol synthesizing process, there are key products for prenylation of low molecular G-proteins such as Rho, Ras and Rac, which are importantly involved in formation of atherosclerotic vascular lesions. Prenylation of G-proteins is essential for the full activity and the proper localization. Therefore, statins are believed to have antiatherogenic activity apart from cholesterol lowering actions. In fact, statins are similarly effective to reduce cardiovascular events in patients with normal LDL cholesterol levels as in hypercholesterolemic. Other pleiotropic effects such as risks on bone fracture, dementia and cancer are discussed, but to finalize the discussion further large scale studies in a clinical setting are definitely needed.View full abstractDownload PDF (2159K) -
2007 Volume 36 Issue 2 Pages 147-
Published: 2007
Released on J-STAGE: December 14, 2012
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