The Journal of Japan Society for Laser Surgery and Medicine
Online ISSN : 1881-1639
Print ISSN : 0288-6200
ISSN-L : 0288-6200
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Volume 10, Issue 4
Displaying 1-7 of 7 articles from this issue
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  • [title in Japanese]
    [in Japanese]
    1990 Volume 10 Issue 4 Pages 1-2
    Published: 1990
    Released on J-STAGE: September 24, 2012
    DOIhttps://doi.org/10.2530/jslsm1980.10.4_1
    JOURNAL FREE ACCESS
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  • Effects of low power laser irradiation on DNA synthesis of cultured synovial cells from patients with RA
    Kunio Yamada, Nobuo Matsui, Takanobu Ohtsuka, Masahiro Hattori, Taiji ...
    1990 Volume 10 Issue 4 Pages 3-10
    Published: 1990
    Released on J-STAGE: September 24, 2012
    DOIhttps://doi.org/10.2530/jslsm1980.10.4_3
    JOURNAL FREE ACCESS
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    Recently, much attention has been paid to the analgesic and anti-inflammatory effects of low power laser irradiation.However,the mechanism remains unclear. In the present study, we have performed experiments of in vitro laser irradiation on cultured synovial cells from patients with RA in order to investigate the effect on DNA synthesis.
    Cultured synovial cells were prepared from synovial tissue obtained during knee joint surgery from six patients with RA. A continuous wave He-Ne laser was irradiated on the cells, with a wave length of 632. 8 nm and a power output of 8.5 mW±20% (11.5 mW measured). Following the irradiation at energy densities varying from 5 to 2000 mJ/cm2, DNA syntheses of irradiated cells were measured by 3H-thymidine incorporation.
    In all six cases,DNA synthesis was significantly inhibited,but each of the cultures showed a different inhibitory response to the irradiation.Morphological observation by a phase-contrast microscope revealed no destructive change by heat energy of laser irradiation.
    Thus, the results suggest that, under the conditions in this experiment,low power He-Ne laser has a direct effect on cultured synovial cells from patients with RA, and inhibits aberrant cell proliferation through a certain non-thermal action mechanism.
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  • Pathological and electron microscopical studies on Nd: YAG laser hyperthermia (laser thermia) on malignant tumor in vivo
    Naoto KANEMAKI, Hiroshi TSUNEKAWA, Madoka ITO
    1990 Volume 10 Issue 4 Pages 11-18
    Published: 1990
    Released on J-STAGE: September 24, 2012
    DOIhttps://doi.org/10.2530/jslsm1980.10.4_11
    JOURNAL FREE ACCESS
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    To investigate the mechanism of tumor cell destruction by hyperthermia using Nd: YAG laser (laser thermia) in vivo, we studied on tumors of the mice which were subcutaneously inoculated Lewis lung carcinoma. After the treatment with laser thermia at 43±0.5°C for 10 minutes with 2.0 watts out put power, we serially observed the pathohistological and electron microscopical changes in the tumor cells and tissue.
    1) Pathological changes: Immediately after the treatment, congestion of the vessels and mild hemorrhage in the tumor were observed. But the tumor cells did not show any morphological alternations. Three hours after the treatment, the hemorrhage in tumor was expanded, and the degenerative changes were observed in the nuclei of tumor cells. Six hours after,shrinking in nuclei and reducing in cell volume were observed. Finally, all of the tumor tissue showed hemorrhagic necrosis 24 hours after.
    2) Electron microscopic changes: Immediately after hyperthermic treatment, swelling of mitochondria with ruptured cristae were observed. Three hours after treatment, degeneration in nuclei and mitochondria were manifested. All tumor cells were destroyed after 24 hours. These results suggest that mitochondria is the first target in the tumor cells treated with laser thermia.
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  • [title in Japanese]
    1990 Volume 10 Issue 4 Pages 19-50
    Published: 1990
    Released on J-STAGE: September 24, 2012
    DOIhttps://doi.org/10.2530/jslsm1980.10.4_19
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    1990 Volume 10 Issue 4 Pages 51-58
    Published: 1990
    Released on J-STAGE: September 24, 2012
    DOIhttps://doi.org/10.2530/jslsm1980.10.4_51
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    1990 Volume 10 Issue 4 Pages 59-64
    Published: 1990
    Released on J-STAGE: September 24, 2012
    DOIhttps://doi.org/10.2530/jslsm1980.10.4_59
    JOURNAL FREE ACCESS
    Download PDF (937K)
  • [title in Japanese]
    1990 Volume 10 Issue 4 Pages 66-69
    Published: 1990
    Released on J-STAGE: September 24, 2012
    DOIhttps://doi.org/10.2530/jslsm1980.10.4_66
    JOURNAL FREE ACCESS
    Download PDF (550K)
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