Results of conservative therapy for microinvasive carcinoma of the uterine cervix was evaluated. One hundred and thirty five cases of microinvasive carcinoma defined as squamous cell carcinoma with stromal invasion not greater than 3mm in depth and without confluent invasion or lymphovascular involvement were included. Excisional conization with laser or loop electrosurgery was selected for the treatment and after the excision, the cut surface was vaporized forming dome-shaped tissue defect. The primary cure was judged after the first trial of the procedure during the follow up, Both ectocervical and endocervical margins of the conizated specimens were examined microscopically. We diagnosed as margin to be positive when displasia or CIS was present in the margin.
Relationship between the cases to be positive for excised margin and those with depth of invasion greater than 1.5mm was significantly correlated (p<0.05). Primary cure rates were 95.4% of 87 cases with laser and 95.8% of 48 cases with loop. No significant relationship was observed between primary cures of each procedure. The frequency of existing lesions within one year from the treatment was significantly higher in the cases diagnosed to be positive in excised margin (p<0.05). But no relations hip was observed between recurrence after one year from the treatment and positive margins. The mean time for the treatment was 4 minutes in loop, 26 minutes in laser. Mean blood loss during operation was not more than 30ml. Pregnancy after the treatment had achieved in 16 cases with laser and in 8 cases with loop. Delivery occurred in 11 cases.

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The purpose of the present study was to investigate the effects of low-energy laser irradiation on bone formation during experimental orthodontic tooth movement in rats. In order to establish a distal movement of the maxillary incisors, 10 grams of orthodontic force was applied for 12 days. A gallium-aluminum-arsenide (Ga-Al-As) diode laser (100mW) was used for 9 minutes, once a day for 12 days, to irradiate the gingiva located at the maxillary incisor roots. Calcein was injected on days 0, 4, 8 and 12 to label the alveolar bone and make specimens for histomorphometrical measurement. Bone formation on the tension side of experimentally moved teeth was significantly accelerated 1.3-fold compared with the non-irradiation controls. Only the early period of irradiation after tooth movement (day 0-4) was effective in increasing the area of bone formation, while irradiation during the latter periods (day 4-8 and 8-12) had no effect. These findings suggest that low-energy laser irradiation can accelerate bone formation on the tension side during tooth movement, and, since this effect was found only in the early period, the timing is very important for acceleration of bone formation. We suggest that laser therapy may be of therapeutic benefit to shorten the treatment period and inhibit relapse through acceleration of bone formation on the tension side during orthodontic treatment.

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