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Volume 16, Issue 1
Displaying 1-6 of 6 articles from this issue
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Yasuo HASHIMOTO, Toru HIRANO, Noboru YAMAGUCHI1995 Volume 16 Issue 1 Pages 1-10
Published: 1995
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSNovel intratumor photodynamic therapy was performed in canine transmissible sarcoma (CTS) utilizing photofrin and excimer dye laser. First, photofrin was injected intravenously at a dose of 5mg/kg. Thirty-two hours later, a laser-proof plastic tube was penetrated into CTS, followed by a photoradiation from the inside of tumor. The mean diameter of tumor necrosis rapidly increased with an increase of total irradiation energy below 240joule/cm resulting that the mean diameter of tumor necrosis was 17mm at an energy of 120joule/cm (max: 84joule/cm2), as well as 20mm at 240joule/cm (max: 168joule/cm2). Beyond 240joule/cm, its diameter gradually increased to 24mm at 1200joule/cm. The side effect of cutaneous tissue showed an open ulcer at 240joule/cm, and a scar at 120joule/cm. The thermal effect of laser light is minimal or negligible below 120joule/cm.
The total energy in the intratumor photodynamic therapy should be decided with a concern about the sensitivity of normal tissue surrounding malignant tumor against the side effect induced by PDT.View full abstractDownload PDF (1522K) -
Tsuyoshi NISHISAKA, Takaaki FUKAMI, Ichiro OKURA1995 Volume 16 Issue 1 Pages 11-15
Published: 1995
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSFluorescence compounds in tumor tissue of C3H/HeN mice implanted with MH134 tumor cells, were analyzed by fluorescence spectroscopy and HPLC, showing that protoporpyrin IX and Zn-protoporphyrin IX are accumulated in tumor cells.View full abstractDownload PDF (8492K) -
Akira KANEDA, Yoshiteru II1995 Volume 16 Issue 1 Pages 17-21
Published: 1995
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSWe developed a diode laser system as a laser light source for Photodynamic Therapy (PDT). PDT is considered as a suitable therapy for the coming aging society since it gives less burden to body or has less side effects. Due to laser condition problems, such as wavelength and output, there was no suitable laser system to popularize PDT and such system was eagerly awaited to be developed. Today, the laser system we newly developed was small and light weighted system with easy operation. Such features will satisfy the needs for PDT and may help to popularize PDT.View full abstractDownload PDF (552K) -
Kazuo HONDA, Katsuhiro KIHARA, Sirou UCHIDA1995 Volume 16 Issue 1 Pages 23-28
Published: 1995
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSSemiconductor lasers have a lot of advantages against other laser systems in many applications. After many research and development efforts on raising output power level, super high power semiconductor lasers higher than 10W are available now and are expected to widen the application of semiconductor lasers. Medical field is one of the most promising applications. We show basic technologies and important characteristics of super high power semiconductor lasers.View full abstractDownload PDF (15874K) -
Toru HIRANO, Kenji SUZUKI1995 Volume 16 Issue 1 Pages 29-35
Published: 1995
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSPhotodynamic therapy (PDT) by means of the photosensitzer PHE and the excimer dye laser (EDL) was first approved by the Japanese government for early stage lung cancer (stage 0 and stage I), esophagus cancer, stomach cancer, cervical cancer and its dysplasia. The construction of the approved excimer dye laser, optical probes for laser exposure and a colposcope for PDT application are described in this paper. We had good treatment results for stage 0 lung cancer, esophagus cancer, stomach cancer, cervical cancer and its dysplasia in the clinical investigational trial of PDT, but not good for stage I lung cancer and bladder cancer because of the imperfection of laser exposure. The reason of the effect of PDT to the deep site of tumor by usig EDL was discussed.View full abstractDownload PDF (31778K) -
Tsunenori ARAI1995 Volume 16 Issue 1 Pages 37-45
Published: 1995
Released on J-STAGE: September 24, 2012
JOURNAL FREE ACCESSHuge effort has been concentrated on photorefractive keratectomy (PRK) studies, which would drastically improve current radial keratotomy (RK) method for correciton of miopia. Since ArF excimer laser ablation for cornea has been the brand-new technology in PRK, there have still many technical and/or physical problems which should be solved. I described the characteristics of current major PRK devices. The devices which were developed in early stage emit a uniform large aperture beam. In contrast, the latest devices emit a narrow non-uniform beam with scanning. It is difficult to judge which kind of devices have superiority. I think PRK device superiority is strongly depended on what kind of ablation is appropriate for PRK. I also explained the details of ablation parameters. The optimun conditions of some parameters are not well-known to estabish complication-free PRK. Humidity control of cornea surface and plume evacuation during laser irradiations are the most uncomprehended factors in conea ablation. The advantages of a large aperture ablation and/or multistep ablation are also unestablished. I think the optimum ablation to attain the complication-free PRK and the PRK device which is able to perform the optimum ablation should be studied.View full abstractDownload PDF (41425K)
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