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Hiroshi Ohkubo, Minoru Hirano, Shigejiro Kurita, Toshiro Kawaguchi, Ta ...
1986 Volume 6 Issue 3 Pages
1-4
Published: 1986
Released on J-STAGE: September 24, 2012
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In treating carcinomas of the tongue, we have employed three types of laser usage. Carcinomas conf ined within the mucosa are treated by laser alone. For carcinomas invading the muscle to some extent, we make a mass reduction surgery by means of laser which is followed by (chemo) radiotherapy. Carcinomas with extensive muscular invasion are first treated with induction chemotherapy. If the chemotherapy is effective, we add laser surgery for the purpose of mass reduction and chemoradiotherapy follows.
26 patients were treated and none has developed local recurrence.
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-mainly its histopathological study
Norihiko Okushima, Misao Yoshida, Hiroyuki Fukui, Hiroshi Ikemoto, Mas ...
1986 Volume 6 Issue 3 Pages
5-10
Published: 1986
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We performed histopathological study of 10 resected specimens of esophageal cancer after photoradiation therapy. After LASER irradiation as the condition of 300~500mW for 5 minutes/
cm2, the specimens revealed that the depth of necrosis reached submucosal layer in all cases (8/8). So, I was sure PRT could kill the cancer cell off within Mucous layer. For 3 or 4 days after PRT, the wall of esophagus got thick and edematous. Mediastinitis and hydrothorax could be seen. At the case after radiological irradiation (7, 340rad), the LASER ulcer could not heal up and perforation into aorta was happened. We must do PRT carefully to the esophagus after radiological irradiation.
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-correspond to remnant or recurrenced tumor-
Akira Sato, Shigeru Asaki, Noriaki Kanazawa, Shuichi Ohara, Daisuke Sh ...
1986 Volume 6 Issue 3 Pages
11-16
Published: 1986
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The first reason of remnant or recurrenced tumor after laser irradiation therapy was that we couldn't sufficiently detect tumor's extent of deep invasion. So, we deviced Submucosography using water soluble contrast medium containing MMC. Owing to this method, we could know extent of tumor's deep invasion preoperatively.
The second reason was that we could not irradiate sufficiently because of perforation and bleeding in depressed typed early gastric cancer especially. So, we deviced combination therapy of endoscopic pure ethanol injection. As to the action of pure ethanol on tumor tissue, it has been shown from our fundamental and clinical studies that pure ethanol caused degenenerative necrosis of tissue to fall.
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Tetsuzo Inouye, Tetsuya Tanabe, Kenichi Inagami, Hideo Tomomatsu, Masa ...
1986 Volume 6 Issue 3 Pages
17-22
Published: 1986
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CO
2 LASER has been widely used for the treatment of benign and malignant tumors in the head and neck area. The LASER provides excellent hemorrhage control by sealing the capillaries. The simultaneous use of CO
2 LASER and Nd-YAG LASER gives even better hemorrhage control. The LASER method of treatment also results in the minimal dissemination of cancer cells improving long term outcome. Survival rate as of April 1985 is 24/27 (89%) and all of the living patients are tumor free histologically. Two patients died of early generalized metastasis after total laryngectomy. One of them died of generalized carcinomatosis, apparently related to the original tumor. For T
2 cases and T
3 cases required total laryngectomy in spite of through irradiation by LASER. One Tlb case had incomplete removal of tumor resulting in recurrence, which was controlled satisfactorily by external X-ray radiation.
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Harubumi Kato, Chimori Konaka, Norihiko Kawate, Katsuaki Nishimiya, Ka ...
1986 Volume 6 Issue 3 Pages
23-28
Published: 1986
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Indications of photodynamic therapy for early stage lung cancer were evaluated in a study of 27 lesions in 26 cases of early stage lung cancer treated by photodynamic therapy. Complete remission was obtained in 16 lesions but remaining tumor was recognized in 11 lesions. Complete remission was obtained in cases with tumor located in only one branch of the bronchiral tree. However remaining or reccurent tumor were observed in cases with tumor located in more than two branches of the branchiral tree. Superficial tumor without metastasis located in only one branch of bronchiral tree are indications for PTD at present. This suggests that the effectiveness of PTD may be limited, at least in part, by mechanical aspects of the present system.
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Kiyoki Okada, Akira Nakano, Hiroshi Asaoka, Tatsuo Amagai, Yasuhiko On ...
1986 Volume 6 Issue 3 Pages
29-33
Published: 1986
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We attempted the recurrent rates of the cases applied with transurethral Nd:YAG laser surgery (TULS) and those with electroresection (TUER) in order to elucidate the efficacy of TULS. Recurrent rates showed statistically no significant difference between two groups. As to the recurrent tumor site, isotropic recurrence treated with TULS appeared lower rate than that with TUER in the primary cases. Therefore, TULS would be an useful method for the treatment of superficial bladder tumor in view of tumor recurrence, in spite of no statistical difference.
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TETSURO KARASAWA, RYOZO TOTANI
1986 Volume 6 Issue 3 Pages
35-40
Published: 1986
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A new surgical procedure, an application of contact type ceramic made scalpel for Nd: YAG laser, to the conization of the uterine cervix is presented. Conization with this new scalpel was performed on 15 patients with either severe dysplasia or carcinoma in situ of uterine cervix. Of these 8 were performed to treat diseases, and the remaing 7 were performed for the purpose of further diagnosis of the affected area or degree of malignancy. The use of ceramic made contact scalpel surpasses any other methods of conization in the following regards. 1) Simplicity of operational procedure. 2) Ideal size and shape of the cone is achieved. 3) Minimal bloodloss during and after operation. 4) Pathological analysis of the removed cone is enhanced. Judging from these benefits, it can be expected, that the application of this conization procedure will most certainly increase in the near future.
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Takashi Kiyoizumi, Jun-Ichiro Kubota, Yukimasa Kuwako, Toyomi Fujino, ...
1986 Volume 6 Issue 3 Pages
41-45
Published: 1986
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By irradiation with a low energy diode laser, four consecutive cases of unexpected multiple hematoma formation under grafted skin found on the seventh or eighth postoperative day showed marked improvement of survival and color match of the graft.
The mechanism of its effect has further to be researched.
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Kiyoo Kamikawa, Munenori Tawa, Taishi Kayama, Masayoshi Ichimi, Yasuta ...
1986 Volume 6 Issue 3 Pages
47-52
Published: 1986
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The thermography was studied together with the low power laser therapy of pain. Symptomatic alleviation was sometimes obtained immediately after the local circulation was improved by the laser therapy. On the other hand the therapeutic effect appeared gradually in the chronic cases during the course of repeated treatments. The thermographic analysis revealed a slight thermal effect at the irradiated area with miniwatts laser, while milliwatts laser worked without detectable thermal effect.
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Nariyuki Hayashi, Takashi Tsubokawa, Shin Kimura, Goro Kido, Atushi Mi ...
1986 Volume 6 Issue 3 Pages
53-58
Published: 1986
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Analysis of specific membrane metabolisms on the malignant tumor cell made a possible to diagnose the tumor localization and new laser photo-chemical anti-tumor treatment, simultaneously.
Platinum blue fluorescein sodium complex (tumor marker, laser reactive anti-tumor drug) was selectively uptaken into the malignant tumor cells with activation of specific external ATPase on the tumor cell membrane. Therefore, N
2-laser irradiation produced very effective anti-tumor function with three different mechanism (1) cellular swelling by change of cell membrane ion metabolism (2) increasing the binding of platinum complex to DNA (3) damage of cell membrane with active oxygen for the malignant tumor. and produced 400/500nm emission fluorescence.
This study opened the new aproach for the treatment of malignant tumor.
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Kyo Huang Niijima, Yasuhiro Yonekawa, Hajime Handa, Waro Taki, Akira K ...
1986 Volume 6 Issue 3 Pages
59-63
Published: 1986
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Sutureless end-to-end anastomosis of rat common carotid artery was carried out, Nd-YAG laser under low power being used thereby. An intraluminal-intervascular splint, made of water-soluble polyvinyl alcohol (PVA), was inserted for precise apposition of the intimas. No stay suture nor glue was required.
The patency rate of the anastomosed vessels, 24 hours after operation, showed as high as 90%. These vessels were confirmed to be likewise patent on the 7th to 30th postoperative day. Complications, for instance, pseudoaneurysm formation and/or stenosis were negligible. The anastomosis stated above was histologically proved to be also satisfactory.
The major advantages of laser technique with PVA splint, such as rapidity, consistency and no residual foreign bodies (thread or adhessive), are discussed.
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Daijo Hashimoto, Yushi Uedera, Kiyotoshi Yabe, Kensho Sanjo, Yasuo Ide ...
1986 Volume 6 Issue 3 Pages
65-70
Published: 1986
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In-depth laser radiation therapy is very effective treatment for irresectable liver cancers. Instead of conventional treatment, we developed the new therapy of percutaneous trans-hepatic laser vaporization without laporatomy. This newly developed therapy will bring some gaspels for patients who can not endure laporatomy, though there are such advantages as accurate laser radiation on the tumor and easy detection of tumors by ultrasound during operation in laporatomy.
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Takuo Nobori, Tetsuya Shima, Yasuhiro Miyazaki, Jyoji Hirota, Masaru O ...
1986 Volume 6 Issue 3 Pages
71-76
Published: 1986
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We have recently developed a new ceramics-tip for localized Laser hyperthermia. A contact YAG Laser probe used for incisions developed into new one for localized hyperthermia when the Laser probe is inserted, into the target tissue. The histological findings in the tongue of a rabbit one day after and 3 days after the localized hyperthermia had been performed. There was no marked tissue damage in the heated area, Both the lipoxygenase and cyclooxygenase metabolites increased somewhat, but after 7 days these metabolites returned to normal conditions.
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-Proposal of New Mechanism“Co-Operative Absorption”of Dye-O2 Complex-
Yusuke Kuroda, Hiroto Kuroda, Yuichi Tanaka, Yoshihiko Kanemitsu, Tada ...
1986 Volume 6 Issue 3 Pages
77-80
Published: 1986
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We measured the optical density ohanges in various concentrations andd solvents of Hematoporphyrin under O
2 and N
2 bubbling. We found the increased abnormal absorption of Hematoporphyrin at 502nm under O
2 bubbling. And the increased optical density was cor elated to the O
2 concentration and concentration of solution. The energy level of 502nm is thought to be sum of energy level of excited triplet state and energy level of singlet oxygen. These support that increased abnormal absorption was produced by “Co-operative absorption”of Hematoporphyrin-O
2 complex.
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Kenichi Ido, Chiaki Kawamoto, Norifumi Hitomi, Ken Kihira, Tomohiko Te ...
1986 Volume 6 Issue 3 Pages
81-84
Published: 1986
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We analyzed hematoporphyrin in the cancer tissue (GCA-1 and HCC-1) transplanted in nude mice, using a alkaline alcohol solvents for the extraction of porphyrins from the tissue, and the elute solvents was 0.1N NaOH-methanol (1: 9). Using the new analytic method by HPLC, it was proved that the hematoporphyrin content in the cancer tissue after i. p. administration decreased moderately day by day. This is similar to the content in nude mice liver. This phenomenon would indicate that hematoporphyrin has affinity with the cancer tissue.
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Yusuke Kuroda, Hiroto Kuroda, Yuichi Tanaka, Yoshihiko Kanemitsu, Tada ...
1986 Volume 6 Issue 3 Pages
85-89
Published: 1986
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The problem of interpretation of solvent effects in photodynamic reaction has been. due to the inability of researchers to distinguish between solvent effects on the rate of decay of singlet oxygen and the rate constants for the reactions of singlet oxygen with organic compounds. We concluded the life time of excited triplet state by measuring T-T absorption induced by Nd-YAG SHG and N
2 dye laser. The life time of excited triplet state in CCl
4 solution was 480ns and in C
2H
5OH solution was 280ns. The difference of life time in CCl
4 solution and C
2H
5OH solution was supposed to be due to radiationless energy transfer by molecular vibration and dissolved oxygen concentration. Determination of life time is thought to be significant to determine the rate equation of singlet oxygen
1O
2 via excited dye triplet state.
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Kenichi Ido, Chiaki Kawamoto, Norifumi Hitomi, Ken Kihira, Tomohiko Te ...
1986 Volume 6 Issue 3 Pages
91-94
Published: 1986
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We analyzed 3
1-Methoxyethyl-8-vinyldeuteroporphyrin (MVD) in the cancer tissue transplanted in nude mice, using a alkaline alcohol solvents for the extraction of porphyrins from the tissue, and the elute solvents was 0.1N NaOH-methanol (1: 9). Using the new analytic method by HPLC, it was proved that the MVD content in the gastric cancer (GCA-1) tissue after i. p. administration was increased than in hepatocellular carcinoma (HCC-1) tissue. This phenomenon would indicate that MVD has more affinity with GCA-1 than HCC-1 cancer tissue.
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Haruo Sato, Roi Tsujimoto, Isumaro Kumadaki, Masatoshi Nishi, Kenichi ...
1986 Volume 6 Issue 3 Pages
95-98
Published: 1986
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The alcohol adducts of protoporphyrin might have a similar or more preferable behavior to tumor tissues than HpD, and planned to synthesize methanol adducts to the double bonds of protoporphyrin.
Two novel compounds (MVD, VMD) were obtained from this reaction and determined these structure to use the nuclear over hauser effect by 400MHz NMR Spectrum
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Harumasa Sakai, Katsuo Aizawa, Harubumi Kato, Chimori Konaka, Norihiko ...
1986 Volume 6 Issue 3 Pages
99-102
Published: 1986
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Various basic and clinical studies have been performed concerning photodynamic therapy (PDT) with hematoporphyrin derivative (PDT). Up to the present argon dye lasers have been used as an excitaion sourse for HpD. Argon dye laser emits a continuous wave beam. Recently we have been using an excimer dye laser which emits a pulse laser beam. It is generally accepted that PDT performed with continuous wave light (E. G. an argon dye laser) results in necrotic changes in tumor tissue up to depth of 5mm. In this experiment we obtained necrotic changes up to about 10-15mm in depth in mouse breast cancer tumor with the excimer dye laser.
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Katsuo Aizawa, Susumu Ohata, Harumasa Sakai, Makoto Saito, Katsuaki Ni ...
1986 Volume 6 Issue 3 Pages
103-106
Published: 1986
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Using a new Excimer pulse dye Laser diagnostic and therapeutic system, it was possible to display fluorescence spectra and the endoscopical imaging patern at the same time on the monitor screen.
Fluorescence spectra in bronchial tree of beagle changed with the lapse of time from the HpD intra venously injection.
After photodynamic therapy, it was cleanly seen that the amount of HpD fluorescence was grealy reduced at the area.
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Nobuo OBARA, Akira TSUCHIYA, Tetsuo MATSMOTO, Yosimi MAMIYA, Tadao AIK ...
1986 Volume 6 Issue 3 Pages
107-108
Published: 1986
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Hiroshi Fujimura, Shigemi Ariyama, Tatuo Otani, Hideto Oshita, Yukinor ...
1986 Volume 6 Issue 3 Pages
109-112
Published: 1986
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Characteristic ESR spectrum is detected only after PRT. This ESR spectrum was considered triplet signal which is peculiar to R
2NO radical. We regarde this ESR spectrum as a product of HpD after PRT. We believe the strength of ESR spectrum is correlative with the volume of HpD which is absorped into cells.
Based on this opinion, we measured the ESR spectrum after PRT with patient. and animals. In the result, we conclude that the second day after HpD injection is most optimum condition for PRT.
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Shinro Mashiko, Shunichi Sato, Humio Inaba, Yoshio Taguchi, Morio Kasa ...
1986 Volume 6 Issue 3 Pages
113-116
Published: 1986
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Spectroscopic measurements including absorption and fluorescence were performed using pheophorbide a dissolved in PBS, which was excited by the fundamental output of a Q-switched Nd: YAG laser and its second harmonic beam. The visible fluorescence thus observed by Nd: YAG laser irradiation was attributed to the two-photon absorption process, although its intensity was about 10
-4 weaker than the case of second harmonic excitation. In vitro experiments using TE-2 cultured esophagus cancer cells uptaken pheophorbide a and Nd: YAG laser output were also carried out. Survival rates of TE-2 cancer cells exhibited exponential decreases with the irradiation time for different dye concentrations, and this two-photon photochemical effect was found more appreciably for higher dye concentration and higher energy density of irradiation laser pulse.
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-Microcirculation Change of Mesenterium during Laser Irradiation-
Motoki YONEKAWA, Tsuyoshi NISHISAKA
1986 Volume 6 Issue 3 Pages
117-120
Published: 1986
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We studied the microcirculatory changes of mesenterium during laser irradiation, using a stereoscopic microscopy. Rabbits were injected with 5mg/kg HpD, one day prior to laser irradiation. In 500mW/cm
2 irradiation series, after 8-10 minutes exposure progressive decrease of blood flow was observed, and after 15 minutes blood flow was completely stopped. If irradiation is stopped before complete stasis, the circulation recovers after a few minutes. These results suggested that disruption of blood flow may be one of the mechanisms of tumor destruction.
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-Action Spectra for killing cell effect-
Hiroshi Nanasawa, Hirouki Nogiri, Kasuhiko Shimada, Shinichirou Fugiku ...
1986 Volume 6 Issue 3 Pages
121-124
Published: 1986
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Cultured cancer cells (HeLa cell) was irradiated by six separate wavelengths (457.9-514.5nm) after HpD treatment.
Irradiation power density was 5mW/cm
2and irradiation time was 30 secs.
Morphological changes of cells were observed by a phasemicroscope after 24 hours of irradiation.
Maximal cell damage of action spectrum (457.9-514.5) was 501.7nm.
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Chiaki Kawamoto, Kenichi Ido, Ken Kimura, Kenichi Manaka, Haruo Sato
1986 Volume 6 Issue 3 Pages
125-128
Published: 1986
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Photodynamic effects of various types of porphyrins on cultured hepatocellular carcinoma cells (JTC-16) were studied, using an argon and dye laser. The porphyrins examined were hematoporphyrin derivative(HpD), hematoporphyrin, protoporphyrin, 3
1-hydroxyethyl-8-vinyldeuteroporphyrin (HVD) and 3
1-methoxyethyl-8-vinyldeuteroporphyrin (MVD). The photodynamic effects on the cells were evaluated by a phase contrast microscope at 24 hours after laser irradiation. An order of cell degeneration was obtained for protoporphyrin>MVD>HpD>HVD>hematoporphyrin.
We conclude that photodynamic effects of porphyrins on the cultured cells would be due to photochemical response, since laser irradiation did not elevate the temperature of culture medium.
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Haruo Sato, Roi Tsujimoto, Isumaro Kumadaki, Masatoshi Nishi, Kenichi ...
1986 Volume 6 Issue 3 Pages
129-132
Published: 1986
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HVD and VHD are cosidered about one of the effective components of HpD, but are not isolated. These compounds can be synthesized by hydrolysis of protoporphyrin. Two dimensional treatment of the nuclear over hauser effect solve to distinguish these structure isomers.
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[in Japanese]
1986 Volume 6 Issue 3 Pages
133
Published: 1986
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T. Hirano, K. Ishida, M. Yasukawa, S. Miyaki, A. Honma, K. Aizawa, H. ...
1986 Volume 6 Issue 3 Pages
135-138
Published: 1986
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We have been developing a new cancer diagnosis and treatment system. This system utilizes HpD as a cancer affinitive material and excimer laser pumped dye lasers as light sources for diagnosis and treatment. The diagnosis is made by observing a HpD's spectroscopic fluorescence curve and a color image of the site expose to the laser beam on a TV monitor. We estimated the amount of HpD fluorescence roughly and confirmed from some experiments that the system can be used effectively for cancer diagnosis. The HpD detection limit was 5×10
-8M/l in PBS solution. We detected HpD which remained in the lung of a beagle dog clealy.
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Shunichi Sato, Susumu Kikuch, Humio Inaba, Yoshio Taguchi, Mirio Kasai ...
1986 Volume 6 Issue 3 Pages
139-142
Published: 1986
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Measurement and comparison of the lifetime of Hematoporphyrin dihydrochloride <Hp. 2HCl>, Hematoporphyrin Derivative <HpD> and Pheophorbide a in PBS solution and TE-2 cultured esophagus cancer cells were performed using a N
2 pulsed gas laser oscillating at 337.1nm in the ultraviolet region. The fluorescence decays of these three dyes in PBS solution were found to be approximated by the superposition of two exponential curves with different amplitudes and lifetimes. In the cases of Hp. 2HCl and HpD in TE-2 cancer cells, however, only one component was dominated and its lifetime was derived to become longer than that in the PBS solution. On the other hand, we obtained two components with different lifetimes from obserbed decay curves for Pheophorbide a uptaken in TE-2 cancer cells. It is conjectured that these different characteristics arise from the differece of accumulated portion of these dyes in the cancer cells.
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H. Konno, T. Kouzu, K. Isono, S. Onoda, K. Okuyama, Y. Yamazaki, M. Ma ...
1986 Volume 6 Issue 3 Pages
143-146
Published: 1986
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We used photoradiation therapy (PRT) in 3 cases of advanced esophageal cancer, which remained after radiation therapy. Each 3 cases ran good course, but had a big and deep ulcer after PRT.
We must develop more tumor-selective method of PRT, to escape from the danger of perforation.
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Katusuke Naito, Haruo Hisazumi, Hajime Yamamoto, Toshiyasu Amano, Kiyo ...
1986 Volume 6 Issue 3 Pages
147-150
Published: 1986
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Spot and total bladder wall photodynamic therapies (PDT) using argon-dye laser (630 nm) were carried out in 17 patients with Ta-TI lesions and in 22 patients with carcinoma in situ (CIS) or/and multicentric superficial tumors, respectively. The intervals between hematoporphyrin derivative 3 mg/kg i. v. injection and PDT were 48 to 96 hours. Total light energy density was 100 to 200 J/cm
2 in spot PDT through a 400 μm quartz fiber and cystoscope, and 10 to 30 J/cm
2 in total PDT carried out by a laser light scattering device. There was no recurrence in 4 of the 17 patients with a mean tumor free time of 20.8 months in spot PDT, and in 5 of 22 with a mean tumor free time of 8.2 months in total PDT. The most appropriate patients for PDT will be those with CIS, those withe diffuse Ta-TI lesions, and those with tumor in a bladder diverticulum.
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(3rd report)
Yutaka Morita, Takayoshi Matsui, Masahiko Kato, [in Japanese], Haruki ...
1986 Volume 6 Issue 3 Pages
151-154
Published: 1986
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N
2 and Ar dye laser were irradiated at dog's liver surface after 5mg/kg HpD administration and the following results were obtained.
1) The depth of tissue damage due to photoradiation therapy (PRT) is not always in proportion to the total energy. Low power and long time irradiation is more effective for the same total irradiated energy.
2) Under the same average power, N
2 dye laser (pulse wave laser) is more effective than Ar dye laser (continuous wave laser) for depth of PRT.
3) Respiration of 100% oxygen is not more effective than that of room air in PRT.
But further examination is needed because the rise of oxygen concentration in the tissue has not been assessed.
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Chimori Konaka, Hrubumi Kato, Norihiko Kawate, Kazuo Yoneyama, Katuaki ...
1986 Volume 6 Issue 3 Pages
155-158
Published: 1986
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Photodynamic therapy (PDT) using hematoporphyrin derivative (HpD) has been performed in cancer cases in our department since 1980. Generally HpD was administed intravanously, after injection of HpD skin photosensitivity occurd. So the patients should stay in shaded parts in the hospital during the day for about four weeks. Recently, in order to avoid such side effects local injections of PDT were performed in the outpatient department. The lesion was photoradiated 72 hours or more after intratumor injection of 1.0 mg HpD. A metastatic skin cancer from the breast, a basal cell cancer of the nose and two lung cancers were treated by this method.
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Yoshihiko Yoshii, Yutaka Maki, Chikashige Kukita, Takao Kamezaki, Masa ...
1986 Volume 6 Issue 3 Pages
159-162
Published: 1986
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This study was designed to assess the therapeutic application of photodynamic therapy (PDT) and hematoporphyrin derivative (HPD) by argon laser with 488 nm wavelength for human glioma. The tissue exposed by argon laser revealed a heterogenously degenerative change of the tissue within the depth of 1mm to 7mm on the dose of less than 311 joules. Tissue temperature increased between 4 and 9°C within a 4mm distant normal tissue from an exposed area during HPD-Argon PDT. The HPD density was observed in the peripheral area of the experimental brain tumor by an intraarterial injection of Mannitol and HPD. The coagulation necrosis was observed within a range of 5.3 mm on diameter by interstitial irradiation.
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-The First Report-
Miho Hayashi, Toshihiko Koga, Kazuo Koga, Masaru Kawakubo, Satoru Ishi ...
1986 Volume 6 Issue 3 Pages
163-166
Published: 1986
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In the experiments of Neodymium-YAG Laser irradiation-employing Meipack, we found that there is the colour specificity for black which 86% was absorbed and permeated but another colours were almost reflected in the area of near infra-red effect of 1.064μm. Because of this laser has longer extinction length than Argon or Ruby laser, so that we can keep the constant distance of the beam irradiation between the end of the fiber and the aimed lesion with the spectrophotometer to avoid over irradiations. Furthermore, the differences of absorption for melanin pigment and collagen fiber which may leads selective irradiation for the subjects.
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Tianming Wang, Hiroji Kuchiwaki, Takehisa Kinomoto, Yoshio Hashizume, ...
1986 Volume 6 Issue 3 Pages
167-170
Published: 1986
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In order to evaluate the safty of the noninvasive laser-doppler-velocimeter that authors are trying to develope, this study was disigned to investigate the histological change of the arterial tissue following irradiation of laser in vivo.
Common carotid arteries of 74 rats (weight 200g) were irradiated unilaterally with a He-Ne laser (NEC GLG 5700 model, wave length 633 nm, power output 27 mW, focus diameter 200 μm) for 5, 15, 30, 60, 120 minutes, respectively, and the histological examination of the artery walls was carried out in 48 hours (acute stage), 1 week (subacute stage) and 4 weeks (chronic stage) after irradiation.
According to irradiation power, the rats were divided into two groups: the full power (27 mW) group and the half power group. Each evaluation consisted of two or three rats. The contralateral common carotid arteries were taken as the control.
Degenerative changes, especially in the middle layer of the artery wall, were found in all the full power group rats and in some of the half power group rats irradiated more than 60 minutes.
It seemed that these pathohistological changes became more remarkable with the longer irradiation time.
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Kiyoji Motomura, Masaharu Nakashima, Akio Ihara, Kazuhiko Atsumi
1986 Volume 6 Issue 3 Pages
171-174
Published: 1986
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Effects of argon-dye laser on rat femur fracturehealing were studied. Argon-dye laser (150-200mW/cm2 x 20 min) was irradiated on the fractured site of Wister-SPF rats and they were sacrificed on 3 to 48 postopera tive days. On the macroscopic findings,large hematoma during irradiation and fibrous stabilization were observed within 5 days in the irradiated group.(control; 10 days) On the X-ray film,the appearance of hydroxy-appatite in the surrounding fibrous tissue was on 14-18 days in the irradiated group.(control;21-25 days) Histilogically,remarkable periosteal reaction and proli feration of cambium layer could be seen within 3 days in the irradiated group. Cartilage cells appeared on 7th day.(control;10th day) However,these cartilage cell remained longer in the irradiated group. From these observation,acceleration of the early phase of fracture healing suspected by the argon laser irradiation.
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Hideki Shinohara, Harubumi Kato, Chimori Konaka, Norihiko Kawate, Kats ...
1986 Volume 6 Issue 3 Pages
175-178
Published: 1986
Released on J-STAGE: September 24, 2012
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Laser stimulation therapy using a gallium-aluminum-arsenide diode laser was performed for pain and ileus, asthma attach, and subjective effectiveness was previously reported to be 92.3%. We consider that the effectiveness is achieved using the autonomic nervous system (ANS). R-R interval on electrocardiogram reveals repiratory changes which reflect the function of the cardiac branch of the vagus nerve, and also the sympathetic nerve. Therefore changes in the R-R interval reflect the function of ANS. Changes in the E.C.G., especially the R-R interval coefficient of variation showed that diode laser stimulation caused excitation of the ANS.
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Norihiko Mikoshiba, Shun-ichi Sato, Shinro Mashiko, Humio Inaba, Yoshi ...
1986 Volume 6 Issue 3 Pages
179-182
Published: 1986
Released on J-STAGE: September 24, 2012
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This is the second report of polarized near-infrared light using light emitting diodes to see its effect on wound healing.
A pair of fresh wounds were made on the back of 60 Guinea Pigs. One of them was irradiated, while the other was not irradiated. Three kinds of lights with different polarization were used for irradiation, i. e. linear, right-hand and lefthand. Each light was irradiated on three groups of animals. All except the left-hand type showed acceleratively effect on wound healing.
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Masahiko Inumaru, Hiroshi Ikezono, Kazuhiro Omagari, Atsushi Toyonaga, ...
1986 Volume 6 Issue 3 Pages
183-185
Published: 1986
Released on J-STAGE: September 24, 2012
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Nd-YAG laser treatment was underwent in 65 of eary gastric carcinomas. Post-laser gastric resection revealed 65% of complete eradication of carcinoma. Post-laser follow-up study of 40 lesins showed 85% negative for cancer cells by endoscopic biopsy examinations. Failure of laser treatment was mostly found in cases with depressed type of M area. In failed cases, the remaining cancer cells was located at anal side (4/7=57%) and at oral side (3/7=43%) of the lesins, Although this is due to difficulty of endoscopic technic, laser treatment for eary gastric carcinoma is very valuable and has great possibility for the treatment of choice.
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Yoshiaki Ito, Hiroshi Sugiura, Akira Kameya, Tomoyuki Kano, Kazukiko T ...
1986 Volume 6 Issue 3 Pages
187-190
Published: 1986
Released on J-STAGE: September 24, 2012
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The efficacy and safety of endoscopic photodynamic therapy (PDT) with hematoporphyrin derivatives (HpD) and Argon dye laser were reported.
The efficacy of the initial treatment was 88% for 8 cases of gastric adenoma, 67% for 30 cases of early gastric carcinoma, and 43% for 7 therapeutic failures of Nd: YAG laser therapy of early gascric carcinoma. Photodynamic therapy with a power of 300mW and the approximate total energy of more than 90 joules/cm
2 seems to be effective for superficially invaded tumor.
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-focussing in recurrence and excurvation of the lesion
Kazumichi Harada, Kazuo Mizushima, Kunio Nakazawa, Masayoshi Namiki
1986 Volume 6 Issue 3 Pages
191-195
Published: 1986
Released on J-STAGE: September 24, 2012
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There were 46 cases of early gastric cancer and 20 cases of ATP treated by YAG laser. 4 cases-IIa:2, I: 2 were followed above 5 years at the longest. 2 (IIc) cases were found recurrence after 1 or 2 years. Depressed type of early gastric cancer is difficult to diagnose using endoscopy alone. It is effective to use of dye dispersing method and endoscopic USG. 2 cases of ATP, were found the recurrence after 1 year and 6 months. The lesions of these cases were large above 2 cm, before treatment. One case of Borrmann I was found the excervation of the lesion at the very short weeks after irradiation. The reason of the excurvation was unknown untill today.
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Yozo Akashi, Ichiro Hayashi, Masaro Kaji, Toshihiko Koga
1986 Volume 6 Issue 3 Pages
197-200
Published: 1986
Released on J-STAGE: September 24, 2012
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We evaluated clinical efficacy of laser irradiation therapy using Nd-YAG laser for 37 cases of early gastric cancer with severe complications since 1982. Five provisions such as 1) position, 2) size, 3) macroscopic finding (elevated or depressed, 4) times of irradiations, and 5) types of specimen were employed for the determination of the therapeutic efficacy. Early gastric cancers with severe complications predisposed to successful laser irradiation therapy are accordingly qualified less than 15mm pore size diameter, being differenciate and elevated in macroscopically.
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T. Koga, T. Ikari, H. Tomimatsu, M. Kawakubo, S. Ishikawa, K. Morizuka ...
1986 Volume 6 Issue 3 Pages
201-203
Published: 1986
Released on J-STAGE: September 24, 2012
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We have experienced a total of 102 early gastric carcinomas (EGC) in the period from May 1982 to March 1985. Forty-four EGCs cases were treated with endoscopic local coagulation therapy (ELT), using the Nd-YAG laser or high frequency electric current (electro-coagulation). The patients (with an average age of 71.1 years) consisted and the remaining 8 were patients with particularly small EGC.
Following ELT treatment no malignancy in biopsy specimens has been found in 34 of the 44 cases (77.3%) by detailed follow-up examinations up to August 1985. No accident and no complication due to ELT occurred. Taking these facts and the safetiness of ELT into consideration, ELT should occupy an important role in the latest treatment of EGCs.
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Ichiro Hayashi, Hiromi Akashi, Masaro Kaji, Toshihiko Koga, Koji Irie
1986 Volume 6 Issue 3 Pages
205-209
Published: 1986
Released on J-STAGE: September 24, 2012
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We report 14 cases of early gastric cancer who had undergone laser radiation therapy in our Hospital since 1982. In particular 5 cases which were treated successfully using laser radiation were closely examined clinically and pathologically through biopsies. All cases were eventually resected.
Early gastric cancers predisposed to successful laser radiation therapy are accordingly qualified maximum pore size 15-20mm diameter, being of differentiate glandular type and with invasion limited to mucosa. Ease of location and accessibility to the endoscope can also be considered.
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Ma Bao-Zhang, Zhou Hui, Qiu Lin
1986 Volume 6 Issue 3 Pages
211
Published: 1986
Released on J-STAGE: September 24, 2012
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Sumiyoshi Koura
1986 Volume 6 Issue 3 Pages
213-216
Published: 1986
Released on J-STAGE: September 24, 2012
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Since 1979 a total of 104 patients with portwine stain have been treated with the Argon Laser at Kagoshima City Hospital.
In this report, changes of histological data and clinical effects during the times after treatment were studied.
Conclusion: the longer the time passed after treatment, the better the effects gained, histlogically and clinically.
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[in Japanese]
1986 Volume 6 Issue 3 Pages
217
Published: 1986
Released on J-STAGE: September 24, 2012
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Takashi Maeda, Toshio Ohshiro, Yu Maruyama, Keiko Iwahira, Takashi Kiy ...
1986 Volume 6 Issue 3 Pages
219-222
Published: 1986
Released on J-STAGE: September 24, 2012
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3188 vascular lesions were treated between 1975 and 1985. These include hemangioma simplex, strawberry mark, telangiectasia and others. Different lasers were used for different lesions. Sometimes two or more lasers were used in combination. We tried to achieve re-epithelialization within 10 to 20 days. The argon laser was the most frequently used, followed by the ruby and dry ice. The diode laser was also used at times, often in conjunction with dry ice. A statistical analysis of treatment methods and lasers used revealed the most effective, least damaging ones for each.
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