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Volume 30, Issue 2
Displaying 1-9 of 9 articles from this issue
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AWARDED ARTICLE
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Atsuhiro Nakagawa, Toshihiro Kumabe, Yoshikazu Ogawa, Takayuki Hirano, ...2009 Volume 30 Issue 2 Pages 119-125
Published: July 15, 2009
Released on J-STAGE: November 02, 2010
JOURNAL FREE ACCESSSurgical instrument with high tissue selectivity may bring about great improvement in survival and functional outcome by attaining maximal resection and functional preservation of vital structures at the same time. Our research organization consisting of medical, engineering, and company investigators have developed a novel method suitable to generate pulsed micro jet for minimally invasive surgery using holmium: yttrium-aluminum-garnet laser. We have been applying the instrument for various neurosurgical entities and planning to expand its indication to endoscopic surgery. The method not only solved the problems addressed in the continuous pressure-driven waterjet instrument, but also remarkable for using mid-infrared laser as driving force to generate high speed jet.View full abstractDownload PDF (2724K) -
Katsunori Ishii, Hideki Tsukimoto, Hisanao Hazama, Kunio Awazu2009 Volume 30 Issue 2 Pages 126-134
Published: July 15, 2009
Released on J-STAGE: November 02, 2010
JOURNAL FREE ACCESSRecently, XeCl excimer laser coronary angioplasty (ELCA) has gained more attention for the treatment of serious stenosis by the formation of multiple plaques within the arteries. ELCA treatments achieve less thermal damages during laser irradiation to atherosclerotic lesions. However, dissections or perforations of coronary arteries limit its safe application. Novel laser angioplasty with high selective ablation and low arterial wall injury is desirable. Mid-infrared laser with a wavelength of 5.75μm is selectively well absorbed in C=O stretching vibration mode of ester bonds in cholesterol esters. The purpose of this study is to develop the novel laser angioplasty using the nanosecond pulsed laser with a wavelength of 5.75μm for the safe atherosclerosis treatment. In this study, we used a mid-infrared tunable solid-state laser which is operated by difference frequency generation as a treatment light source, and a thoracic aorta of WHHLMI rabbit as an atherosclerosis model for studying the selective removal of atherosclerotic lesions. This study showed that nanosecond pulsed laser irradiations with a wavelength of 5.75μm realized the selective and less-invasive treatment of atherosclerotic plaques. This technique realizes a safe treatment because it is possible to treat differently between tunica intima and media, and does not perforate a normal aorta in principle.View full abstractDownload PDF (3682K)
ORIGINAL ARTICLE
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Hideyuki Murayama, Kei Sadakane, Banri Yamanoha, Shinichi Kogure2009 Volume 30 Issue 2 Pages 135-140
Published: July 15, 2009
Released on J-STAGE: November 02, 2010
JOURNAL FREE ACCESSIt has been reported that low-power laser irradiation (LLI) can modulate various biological processes including cell proliferation. Some reports suggest LLI interferes with cell cycle and inhibits cell proliferation, while others suggest LLI has a stimulatory effect. Mechanism underlying the effect of LLI remains unclear. To develop an LLI therapy for cancers, the present study was designed to examine effects of LLI on the cell proliferation of human-derived glioblastoma A-172. Diode laser with a wavelength of 808 nm was used. The A-172 cells were cultivated in culture dishes or a 96-well plate. No irradiation was applied in control-group, whereas in experimental group, the center of dish or the selected well was irradiated for 20, 40 and 60 min, respectively. Cells were cultivated in CO2 incubator for 2 days. The dishes or wells were photographed at pre-, just post-irradiation, 24 and 48 hrs after irradiation with a digital camera. Cell countings were performed on the PC screen and the ratio of cell proliferation was measured. MTT assay was also applied at 48 hrs after irradiation and viable cells were estimated. Both analyses showed that LLI (60 mW) provided a significant suppressive effect on the proliferation of A-172 cells (p<0.05 or p<0.01), and that the effect of LLI had a dose-dependency. It is concluded that LLI used in the present study has a potential of suppressive effect on the cell proliferation of human-derived glioblastoma A-172.View full abstractDownload PDF (2445K) -
Atsushi Nanashima, Takashi Nonaka, Hiroyuki Yamaguchi, Syuuichi Tobina ...2009 Volume 30 Issue 2 Pages 141-145
Published: July 15, 2009
Released on J-STAGE: November 02, 2010
JOURNAL FREE ACCESSPhotodynamic therapy, which is a cancer-specific treatment radiated by a specific wave length of laser beam to the injected photosensitizer specifically accumulating in cancer cells, has been established as a useful treatment for superficial lesion in esophageal, gastric or lung carcinomas. While, the adequate local treatment would be expected to control local extension in biliary carcinomas because this factor is closely related to patient prognosis. PDT was supposed to a useful treatment option. In bile duct carcinomas, clinical trials have been started from 2000 in European countries and, in Japan, only a few institutes perform PDT in biliary carcinomas. Possibility as one of multi-discipline treatments would be expected because of its effectiveness and safety. We discuss a prospect of presence and future of PDT in biliary carcinomas in the new era.View full abstractDownload PDF (1768K)
Topical papers: Laser Surgery in Otorhinolaryngology, Head and Neck Surgery
REVIEW ARTICLE
REVIEW ARTICLE
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Katsuhisa Ikeda2009 Volume 30 Issue 2 Pages 146
Published: July 15, 2009
Released on J-STAGE: November 02, 2010
JOURNAL FREE ACCESSDownload PDF (285K) -
Kazunori Nishizaki2009 Volume 30 Issue 2 Pages 147-151
Published: July 15, 2009
Released on J-STAGE: November 02, 2010
JOURNAL FREE ACCESSKTP, Argon, and carbon dioxide lasers are used for otologic surgery including stapes surgery. A KTP laser occupied the leading role of lasers used in otologic surgery. However, with the maintenance period having been finished, a diode laser having a similar characteristic to a KTP laser might succeed to the position in future. I mention my own experience using a KTP laser and the future of the laser surgery in otologic field.View full abstractDownload PDF (1453K) -
Takehisa Saito2009 Volume 30 Issue 2 Pages 152-158
Published: July 15, 2009
Released on J-STAGE: November 02, 2010
JOURNAL FREE ACCESSClinical indications, applications and efficacy of laser surgery in the oral cavity and oropharynx were reviewed. Five lasers used in these regions were CO2, KTP/532, Nd:YAG, Ho:YAG, and diode lasers. The lasers are used for cutting and ablation of tissue and the coagulation of tissue surfaces. Indications of laser surgery are excision of superficial malignant tumors, premalignant lesions (leukoplakia), and other benign lesions. The KTP/532 laser surgery is good indication for hemangioma. The most important laser applications in these regions are in tonsillar surgery (laser tonsillectomy), and soft palate surgery (laser-assisted uvulopalatoplasty) and laser midline glossectomy for obstructive sleep apnea syndrome. Advantages of laser surgery are spontaneous occlusion of small transected vessels providing hemostasis, an almost bloodless field, precise incisions under microscopic control, and no need for sutures. Furthermore, scar formation in the wound after laser cutting and ablation was less compared with conventional scalpel wound. This leads to better functional results on swallowing and speech even after large surgical defects.View full abstractDownload PDF (2740K) -
Akihiro Shiotani2009 Volume 30 Issue 2 Pages 159-164
Published: July 15, 2009
Released on J-STAGE: November 02, 2010
JOURNAL FREE ACCESSLaser has now become an important tool in the laryngeal and tracheal surgeries, providing sharp and bloodless cut in the narrow and long surgical fields. In this article, usefulness of various lasers and surgical procedures in microlaryngeal surgery, which is basic surgical setting in the laryngeal and tracheal surgeries, for various laryngeal diseases are reviewed. In laryngeal cancer, CO2 laser surgery is indicated for T1-T2 lesions. However, in Europe, fractional tumor resection is spread and even T3-T4 lesions are indicated. In the near future, the spread of this European surgical concept is anticipated in Japan. In laryngeal papilloma, in addition to the CO2 laser vaporization, postoperative adjuvant therapy is important for the prevention of the recurrence. In laryngeal hemangioma, KTP laser coagulation is effective as well as resection using CO2 laser. In laryngeal stenosis, only hemicircle of stenotic area is resected with laser and another hemicircle of epithelium is left intact, enabling the stent insertion unnecessary. In bilateral recurrent laryngeal nerve paralysis, transverse cordotomy and laser arytenoidectomy using CO2 laser are representative endoscopic procedures to widen the glottis.View full abstractDownload PDF (2167K) -
Shin Ito, Fumihiko Matsumoto, Shinichi Oba, Mitsuhisa Fujimaki, Jyunki ...2009 Volume 30 Issue 2 Pages 165-169
Published: July 15, 2009
Released on J-STAGE: November 02, 2010
JOURNAL FREE ACCESSThe merits of laser surgery in head and neck tumor include a slight contraction of the muscles, a minimal bleeding, and the clear wound after laser surgery. The laser therapy of malignant tumor has several advantages including a shorter period of treatment than radiation therapy and no induction of the second carcinoma.
How to use of the laser therapy for malignant tumor of head and neck is single treatment or combination treatment (laser and radiation). The single therapy of the laser is good indication for cancer of tongue and oral cavity (T1, early T2), and laryngeal cancer especially glottis (Tis, T1a).
They are not a difference of prognosis between laser therapy and radiation therapy. However, the operations have to pay a careful attention to side effects of laser beams.View full abstractDownload PDF (1766K)
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