A practical method divised by the author to collect the adrenal venous blood of the rat was described. Adrenal cholesterol and comp. B and F like substances were estimated by Sperry-Webb and Sweat's method to study the effects of baths on the adrenal cortex.
Therefore adrenal cholesterol and chemocorticoids in the adrenal venous blood of 91 rats (48 hypophysectomized, 43 normal) were estimated 4 hours after a bath, and serum cholesterol of 26 rats (13 hypophysectomized, 13 normal) were compared with adrenal cholesterol after a series of daily baths during a week. And following results were obtained.
1) Thoron bath (at 37°C for 20min. or at 42°C for 15min.) and soft water bath (at 42°C) decreased the adrenal cholesterol and increased comp. B like substance in the adrenal venous blood of the normal rats.
2) Thoron bath decreased the adrenal cholesterol of normal rats after a series of baths at 42°C during a week. No such effect was seen by the soft water baths. But serum cholesterol was increased especially by the former.
3) As regards to the hypophysectomized rats, Thoron bath (at 37°C and 42°C) decreased the adrenal cholesterol, and increased comp. B like substance in the adrenal venous blood.
4) Chlorpromazine injection did not inhibit the effects of Thoron bath on the adrenals of hypophysectomized rats.
5) A series of daily baths during a week at 42°C increased the adrenal cholesterol and decreased the serum cholesterol of hypophysectomized rats especially in the case of soft water.
The facts, that hypophysectomy and chlorpromazine could not inhibit the effects of Thoron bath, suggest that there must be a direct action of Thoron to the adrenals or some by-path which transmits stmuli of the Thoron bath to the adrenals, not via pituitary or sympathicus.

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The author has intended to study how varies the frequency of onset of labor when a frontal line passes. For this purpose, he has applied Masuyama's spatial nmethod.
Among all parturitions at San-ikukai Hospital (Tokyo) in 1952-53, 3527 cases have been investigated, where onsets of labor were spontaneous and durations of pregnancy were over 36 weeks. The frequency of onset of labor was calculated, whereby seasonal and diurnal errors were eliminated.
The result is as follows: when a depression passes near Japan, the frequency of onset of labor shows a significant variation, namely, it increases before a cold frontal line passes (containing the case where a warm frontal line approaches or passes) and decreases after it passes. These influences are confirmed within the range of 24 hours before or after the passage of cold frontal line respectively (in terms of distance, within 1000km before or behind the cold frontal line).
At last, he has discussed the cause of this phenomenon in connection with autonomic nerves and posterior pituitary gland hormones.

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General survey of hot spring curative treatment at Onogawa Spa, Yamagata Prefecture, and the effect of this Spa on the healing of wounds and the variation of the blood pressure were reported. The results of our medical survey may be summarized as follows:
1) The larger number of visitors to this Spa are those who live in Yamagata Prefecture, the majority being farmers in the vicinity of the city of Yonezawa. Most of them are old men and women over fifty years of age, the number of women being twice that of men.
2) Onogawa Spa is mostly used as a place of recreation by people living in the vicinity of the city of Yonezawa, only one fourth of them coming there for therapeutic or convalescing purpose.
3) The examination of diseases for which they come to this Spa reveals that neuralgia stands at the top, followed by fact that this Spa is empirically known as “the hot spring for the digestive organs”.
4) More than 80% of the visitors to this Spa are those who have been here before, but very few come there in consultation with or under the direction of a physician. The number of days they stay at this Spa is short, and the number of bathing is, on an average, 4.9 times a day. Tendency similar to those observed in other hot-spring resorts in the Tohoku Region is observable in the results obtained in the present medical survey.
5) Bathing in Onogawa Spa is effective in the healing of wounds; its healing process is good macroscapically, and it is observed histologically that new vascularisation and granulation are vigoraus in process.
6) Considering the variation in the blood pressure, it may be said that bathing in a high-temperature hot spring (45°C) at this Spa is not always good for patients with marked hypertension.

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In the previous paper the author reported beneficial effects of thermal baths at the Kageyu Spa on hypertension and sequelae of so-called cerebral apoplexy.
The present report describes the effects of the hot spring bathing and drinking on hypercholesterolemia and atherosclerosis of rabbits fed on cholesterol. The results were as follows:
1) Remarkable hypercholesterolemia and atherosclerosis were observed in rabbits fed daily on cholesterol (0.1gm./Kg.) for 60 days. Daily hot spring bathing (at 37°C, for 30 minutes) or drinking (10cc./Kg.) commenced simultaneously with the feeding showed marked suppressive effects on both hypercholesterolemia and atherosclerosis, while daily plain water bathing or drinking under the same condition as in the hot spring treatment proved not so effective.
2) After 60 days of cholesterol feeding, the hot spring bathing and drinking or plain water bathing and drinking were carried on for 20 days respectively. Though high serum cholesterol level decreased spontaneously after the cessation of cholesterol feeding, daily plain water bathing or hot spring drinking among the various treatments seemed to have some beneficial effect on the decrease. On atherosclerosis, however, no curative effect was shown by any treatments.
3) During 90 days of cholestesol feeding, daily bathing in the hot spring or plain water (at 37°C, for 30 minutes respectively) was commenced on the 61st day and carried on till the 90th day. By daily hot spring bathing further aggravation of hypercholesterolemia was inhibited and atherosclerosis was proved to be in somewhat slighter degree than that observed in control group, while the suppressive effect of plain water bathing on hypercholesterolemia was not so remarkable as that of the hot spring bathing and no antiatherosclerotic effect was shown.
4) During 70 days of cholesterol feeding, daily bathing in the hot spring or plain water (at 37°C, for 30 minutes respectively) was commenced from the 31st day. By daily hot spring bathing not only further aggravation of hypercholesterolemia was suppressed but also a decrease in serum cholesterol level was observed inspite of keeping on feeding cholesterol and the degree of atherosclerosis was slighter than that observed in control group. By daily plain water bathing some suppressive effect on hypercholesterolemia was indeed shown but in slighter degree than that shown by the hot spring bathing, and no antiatherosclerotic effect was revealed.
With above-mentioned results it is concluded that (1) the suppressive effects of Kageyu Hot Spring on hypercholesterolemia and atherosclerosis of rabbits fed on cholesterol are due not only to indifferent temperature of the bath water but also to some special chemical constituents in the thermal water and (2) the prophylactic use of the spring is more effective than the curative one.
The author discussed the significance of SO₄ ion, which is a principal anion constituent in the thermal water of Kageyu.

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We examined 6 labourers who were working in temperature of 43°C and humidity of 100% by usiug Motokawa, s flicker method for measuring fatigue.
1. The values of flicker threshold ascended as soon as they worked and reached the highest values at the moment when their morning works ended.
After their lunch the values had tendency to turn back to the values before working and began to ascend again by their afternoon working and turned back to the values before working after they finished their working.
2. We can prove the great differences comparing aforesaid results of labourers with that of control people.

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Thirty six intact and hypophysectomized rats were treated with acupuncture or moxibustion, 3 times on each site: “Chukan”, “Shinchu” and “Jinyu”.
Three hours after the treatment eosinophil leucocyte counts in peripheral blood, adrenal weight, adrenal ascorbic acid and cholesterol contents of the animals were determined.
Results obtained were as follows.
1) In the intact group, both treatments decreased eosinophil counts remarkably but adrenal weight was not significantly influenced.
A considerable diminution in ascorbic acid content was seen in the group of acupuncture but a decrease in cholesterol content proved rather remarkable in the group of moxibustion.
2) Even in the hypophysectomized animals following results were observed: eosinophil leucocytes decreased slightly after acupuncture, adrenal weight showed a tendency to decrease, ascorbic acid and cholesterol were diminished by both treatments, especially by acupuncture.
3) From these experiments it was concluded that acupuncture was more effective to stimulate the adrenals than moxibustion under the above mentioned erprimental condition.
4) The authors proved that acupuncture and moxibustion could influence the adrenals even not via pituitary.

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