循環制御
Print ISSN : 0389-1844
27 巻 , 4 号
選択された号の論文の5件中1~5を表示しています
原著
  • Seijiro Sonoda
    2006 年 27 巻 4 号 p. 346-351
    発行日: 2006年
    公開日: 2008/02/11
    ジャーナル フリー
    The purpose of this study is to investigate the hypothesis that epidural analgesia combined with fentanyl suppresses endocrine responses and prevents renal impairment during thoracotomy. Thirty patients undergoing elective lung lobectomy via thoracotomy were randomly divided into three groups according to the anesthetic method. The patients of group GA received only general anesthesia. Those in group CGE received general anesthesia and epidural analgesia with 1% mepivacaine. Those in group F received general anesthesia, epidural analgesia with 1% mepivacaine, and fentanyl given both intravenously and to the epidural space. Plasma cortisol and aldosterone were measured as indicators of the endocrine response. Urinary output of N-acetyl-beta-D-glucosaminidase(NAG) was also measured as an indicator of renal tubular damage. In group F, NAG and cortisol releases were suppressed. NAG increased by 191% and by 119%, and cortisol increased by 247% and by 167% in group GA and CGE, respectively(p<0.05). In group F, the aldosterone release was attenuated down to 48% over the pre-operative values, while it increased markedly by 358% and by 264%, in group GA and CGE, respectively. These results suggest that fentanyl in addition to epidural analgesia attenuates the endocrine responses and the renal tubular damage during thoracotomy.
  • 齊藤 直, 河原 剛一
    2006 年 27 巻 4 号 p. 352-357
    発行日: 2006年
    公開日: 2008/02/11
    ジャーナル フリー
     本研究では,心筋梗塞によるリモデリング心が虚血・再灌流傷害を受けた際の脆弱性と NCX 発現動態との連関の解明を目的とした.雄の成体ラットにおける心筋梗塞由来リモデリング心を摘出して灌流心を作製し,虚血・再灌流傷害負荷を与えた結果,対照心と比較して有意な NCX1 発現量の増加および Caspase-3 活性と Calpain 活性の増加が確認された.このことは,心筋梗塞による心室リモデリング時に NCX 発現量が増加したため,その後の虚血・再灌流傷害時に NCX 機能逆転による細胞内 Ca2+濃度上昇が促進され,その結果アポトーシスの誘導が促進された可能性を示唆している.
症例
feedback
Top