CHEMOTHERAPY
Online ISSN : 1884-5894
Print ISSN : 0009-3165
ISSN-L : 0009-3165
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Volume 20, Issue 2
Displaying 1-7 of 7 articles from this issue
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  • CHEMOTHERAPY OF THE UPPER URINARY TRACT INFECTIONS
    YOJI NISHIMURA
    1972 Volume 20 Issue 2 Pages 287-290
    Published: March 25, 1972
    Released on J-STAGE: March 08, 2011
    DOIhttps://doi.org/10.11250/chemotherapy1953.20.287
    JOURNAL FREE ACCESS
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    Clinical evaluation was made on cephalexin and ampicillin by double blind method in patients with non-obstructive acute pyelonephritis whose isolated organisms were mostly Escherichia coli.
    Treatment regimens of the drugs were ampicillin 2 g daily and cephalexin 1 g and 2 g daily for the period of 1 week and 2 weeks respectively.
    Clinical effectiveness in each treatment regimen was as follows :
    The effectiveness was 46% with ampicillin 2 g daily and 86% with 1 g daily and 89% with 2 g daily of cephalexin for 1 week therapy, and 68% with ampicillin 2 g daily and 88% with 1 g daily and 63% with 2 g daily for 2 weeks therapy.
    Relapse was observed after withdrawal of therapy in each 1 case with ampicillin 2 g daily for 1 week group and cephalexin 1 g daily for 2 weeks group.
    No severe side effect was observed in this study excepting 2 cases of gastrointestinal disturbance in ampicillin group.
    A tentative proposal was made on the criteria for evaluating clinical response of chemotherapy.
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  • ANTITUMOR EFFECT OF NUCLEIC ACID ANALOGUES (III)
    Tumor-specificity of Purine-analogues in the Inhibition of Nucleic Acid Biosynthesis
    HISAKO TONEGI, MARIKO NAGANUMA, SHIGESHI TOYOSHIMA
    1972 Volume 20 Issue 2 Pages 291-296
    Published: March 25, 1972
    Released on J-STAGE: March 08, 2011
    DOIhttps://doi.org/10.11250/chemotherapy1953.20.291
    JOURNAL FREE ACCESS
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    To establish an advanced screening method to find less toxic antitumor agents, the effect of several purine analogues on the biosynthesis of protein and nucleic acids in various cell-lines was investigated.Mitomycin-C, Iododeoxyuridine and Cycloheximide inhibited either of malignant cells and non-malignant cells, while 6-Mercaptopurine, 6-Mercaptopurine riboside, Thioguanosine and Bis (6-Mercaptopurine ribosibe) compound inhibited remarkably the biosynthesis of nucleic acids in malignant cells, but fairly that of non-malignant cells. These findings suggest that such an in vitro screening system may be useful to find less toxic antitumor agents.
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  • ANTITUMOR EFFECT OF NUCLEIC ACID ANALOGUES (IV)
    The Relationship between the Tumor-specificity of 6-Mercaptopurine and its Penetration into Cells
    MARIKO NAGANUMA, SHIGESHI TOYOSHIMA
    1972 Volume 20 Issue 2 Pages 297-298
    Published: March 25, 1972
    Released on J-STAGE: March 08, 2011
    DOIhttps://doi.org/10.11250/chemotherapy1953.20.297
    JOURNAL FREE ACCESS
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    The penetration of 14C-6-Mercaptopurine (6-MP) into cells was investigated. In Hep. No. 2 cells, the penetration rate of 6-MP was remarkably higher than that in chick embryo fibroblast cells. The nucleic acid synthesis of the former cells was more sensitive on 6-MP than that of the latter cells. Between the passaged and strained cells tested, the penetration rate in MDBK cells was higher than that in L cells.
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  • ANTITUMOR EFFECT OF NUCLEIC ACID ANALOGUES (V)
    Studies on Nucleic Acid Analogues showing Specific Inhibition on Nucleic Acid Synthesis of Tumor Cells
    SHIGESHI TOYOSHIMA, HISAKO TONEGI, MARIKO NAGANUMA, YOSHIKO NAKAMURA
    1972 Volume 20 Issue 2 Pages 299-304
    Published: March 25, 1972
    Released on J-STAGE: March 08, 2011
    DOIhttps://doi.org/10.11250/chemotherapy1953.20.299
    JOURNAL FREE ACCESS
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    One hundred nucleic acid analogues were screened as to their effect on the synthesis of DNA and RNA in either of tumor cells and non-tumor cells. Among 100 compounds, 6 analogues were found to be inhibitory selectively on the biosynthesis of nucleic acids of tumor cells.
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  • [title in Japanese]
    1972 Volume 20 Issue 2 Pages 305-316
    Published: March 25, 1972
    Released on J-STAGE: March 08, 2011
    DOIhttps://doi.org/10.11250/chemotherapy1953.20.305
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    1972 Volume 20 Issue 2 Pages 316-332
    Published: March 25, 1972
    Released on J-STAGE: March 08, 2011
    DOIhttps://doi.org/10.11250/chemotherapy1953.20.316
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    1972 Volume 20 Issue 2 Pages 332-431
    Published: March 25, 1972
    Released on J-STAGE: March 08, 2011
    DOIhttps://doi.org/10.11250/chemotherapy1953.20.332
    JOURNAL FREE ACCESS
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