Branhamella catarrhalis has long been considered to be a harmless upper respiratory tract commensal of humans.Its recent recognition as a significant of pathogen lower respiratory tract infection in patients with conpromized pulmonary function underscores the needs for prompt and reliable isolation and identification of
Branhamella catarrhalis.
Minimum inhibitory concentration (MIC) values for 29 antibiotics against 31 strains of
Branhamella catarrhalis and 34 strains of non-pathogenic
Neisseria species, isolated from patients with respiratory tract infection, were measured with an inoculum size of 10
6/ml. In the MICs of 29 antibiotics (6 penicillins, 12 cephalosporins, 3 aminoglycosides, 2 macrolides, minocycline, chloramphenicol, sulfamethoxazole-trimethoprim and nalidixic acid), the geometric mean MICs for the clinical isolates of
Branhamella catarrhalis were almost uniformly lower than the MICs of the corresponding antibiotics for the clinical isolates of non-pathogenic Neisseria species.
50 % of the
Branhamella catarrhalis isolates produced β-lactamase. MICs of amoxicillin and cefoperazone for the 16 strains of
Branhamella catarrhalis were significantly diminished by combination of clavulanic acid or CP 45899. But these MICs for the 34 strains of Neisseria species were not affected by clavulanic acid or CP 45899.
View full abstract