1) 31 patients have been introduced to our clinic from the dental hospital during the for past five years. Among them,18 were psychiatric outpatients who needed psychiatric treatment and advice. Thirteen other patients developed various neurotic symptoms after the dental treatment, such as setting a bridge or a crown. The latter were cases of PSD, in the dental division, or TMJ functional disturbances.

2) A case of temporomandibular arthosis was analysed from the psychiatrists point of view. Furthermore, a current diagnostic approach and a way to the introduce the psychiatric method to such patients was suggested.

3) Considering the progress in both the medical and dental field, it is necessary to pay attention to cases in both of these fields. So we examioned how to trest the case that develop both mental and physical symptoms. Consequently, it is suggested that the cooperation between both fields and the comprehensive approach is necessary.

We have studied the relationship between the ability of slime production of Staphylococcus epidermidis and its adherence to a plastic petri dish and relationship between the ability of slime production of S. epidermidis and its surface hydrophobicity. We have also studied the virulence of the slime-producing strains and slime-nonproducing strains of S. epidermidis. The adherence of slime-producing strains was poor and the hydrophobicity was low, when compared to the slime-nonproducing strains. We obseved no relation between the ability of slime production and its adherence to a plastic petri dish or between the ability of slime production and its surface hydrophobicity. The chemical analysis of the extracellular substances of the slime-producing strains revealed an increase in protein content. When analysing extracellular substances by using SDS-PAGE, we observed specific glycoprotein (MW 24,000) that of the slime-producing stram.

The virulence of the slime-producing S. epidermidis ATCC 14990 was stronger than that of the slime-nonproducing S. epidermidis STE-38 in mice.

These results suggest that the specific glycoprotein (MW 24,000) is closely associated with the virulence of S. epidermidis.

We performed a susceptibility test using 54 strains of Haemophilus actinomycetemcomitans isolated from healthy adults, patients with periodontitis and patients with juvenile periodontitis. 40 antimicrobial agents: 7 penicillins, 14 cephems, 3 aminoglycosides, 3 tetracyclines, 3 macrolides, 7 pyridone carboxylic acids, aztreonam, chloramphemicol, and sulfamethoxazole-trimethoprim were used.

All strains showed good susceptibility to these antibiotics except sulfamethoxazole-trimethoprim (MIC₅₀, 1.56 to 3.13μg/ml and MIC₉₀, 12.5 to 25μg/ml). Particularly good susceptibility to cefmetazole and cefminox (MIC₅₀, 0.025 to 0.1μg/ml and MIC₉₀, 0.05 to 1.56μg/ml), as well as ofloxacin, enoxain and ciprofloxacin (MIC₅₀, 0.1 to 0.2μg/ml and MIC₉₀, 0.1 to 0.39μg/ml) was observed. In piperacillin, cefuroxime, cefmetazole, kanamycin, amikacin, sisomicin, piromidic acid and pipemidic acid, the isolates MICs from healthy adults were similar to those from patients with periodontitis, but the isolates MICs from patients with juvenile periodontitis showed lower values than the other two groups.

A histopathological study of intentional vital submergence of tooth-roots, covered with or without periosteum, was made in 15-month-old male Beagle-dogs. After horizontal amputation of molar teeth at the same level as the original alveolar crest, the cut root-surfaces were covered with a mucoperiosteal flap in the experimental group, while cut root-surfaces were covered with a mucosal flap in the control group. The animals were sacrificed 1, 3, 6, 12 and 24 weeks after the surgical operation. The resuits were as follows:

The degree of postoperative inflammation and the amount of granulation tissue in the experimental group was less than those in the control group. Organization of the granulation tissue with an aggregation of immature mesenchymal cells was noted one week after the operation in the experimental group. Such change of granulation tissue began three weeks after the operation in the control group. The amount of newly formed trabecular bone in the fibrous tissue above the cut root-surface in the experimental group, was greater than that in the control group. Some insignificant changes in amputated pulp tissue were observed in both the experimental and control groups. These findings suggest that intentional vital submergence of tooth-roots covered with the mucoperiosteal flap is more satisfactory than when using the mucosal flap.

Cliniopathological analysis of cases of pleomorphic adenoma occurred in the minor salivary glands in Dental Hospital of Iwate Medical University was made. Cases of pleomorphic adenoma occupied 60.9% of all minor salivary gland tumors, and 98.5% of benign minor salivary gland tumors. Age of the patients ranged from 16 to 93-year-old, and its average age was 46.1. It was somewhat more frequent in females than in males, the ratio approximating 2: 3. Pleomorphic adenoma showed a tendency to be more frequent in the hard palate, less in the soft palate, and still less in the cheek and upper lip.

We have previously described a tumor-bearing host that may be should be due to a decrease in the capability of lymphoid cells to recognize antigen according to tumor growth. Then in oder to prove tumor specific immunity, it is necessary also to give the proof on the tumor autoimmunity against spontaneous carcinoma in WHT/Ht mice. Therefore in this study we observed tumor growth by a direct challenging experiment against tumor immunized mice.

Using the Takeda ligation-release method, the preimmunization procedure with irradiated tumor cells by Klein, as well as other immunization methods by xenogenization which use formalin treated tumor cells, serial passage culture tumor cells and ⁶⁰Co irradiated tumor cells, mice were immunized and then challenged with viable tumor cells.

Mice could not be immunized using Takeda’s methed. The others showed a delay in development of cancer and their survival time was lengthened. Especially in Klein’s method an increased resistance of tumor cells was demonstrated with four out of twelve tumors in the autochthonous hosts. But in all of the other immunization methods such resistance could not be demonstrated.

Therefore it seems that tumor immunity may be shown in spontaneous carcinoma host. Furthermore we could detect surface staning of tumor cells with C3 components by labeling FITC in 7 and 14 day tumor-bearing mice. But we could not detect stained tumor cells in the last 20 days of the tumor-bearing mice.

Thus, the tumor immune reaction has been brought on in the early days of tumor-bearing hosts. However, the immunological tolerance seems to decrease as the tumor grows.

We observed two cases which had two and three supernumerary teeth in the right and left premolar regions of the mandible. In case 1, the teeth were on the mesio-lingual side of the mandibular first molar, on the mesial side of the mandibular first molar on the dental arch and in the mandible near the disto-lingual side of the left canine. In case 2, the supernumerary teeth were between the lingual side of both the first and second premolar.

These teeth were smaller than the average Japanese premolar. However, the other teeth were larger than the average Japanese tooth. Especially, the bucco-lingual diameter of the tooth was larger. In our observations of the tooth characteristics, the cingulum was greatly accentuated in case 1, but not in case 2, where the cingulum was no different from the average. On the contrary, the distance of the distal cusp of the mandibular molar was longer in case 2. Therefore, these teeth were more developed.

We could not conclude whether or not the supernumerary tooth appearance was related to the tooth size and/or other characteristics. However, it is important that much date of such cases be reported and studied.

This paper reports a rare case of a complex odontoma found in the gingiva of a 23-year-old female.

Intraoral examination revealed that a mass of hard tissue was exposed from the gingiva of the lower third molar regin. X-ray examination revealed that the hard tissue mass had a tooth-like radiopacity, and was located on the impacted lower third molar tooth. This hard tissue mass was removed surgicaily under local anesthesia, and was easily removed from the gingiva. The hard tissue mass was the size of a soy-bean, irregular and oval in shape and yellowish white. By histopathologic examination and contact microradiographic examination it was diagnosed as complex odontoma.

An autopsy case of double cancer in the stomach and the tongue was reported.

A 64-year-old man had esophagojejunostomy with total gastrectomy due to poorly differentiated adenocarcinoma of the stomach. About one year later, he suffered from tongue cancer. The histological type was squamous cell carcinoma. Cases of double cancer which include a tongue cancer are more common than cases of double cancer which develop in other oral organs.