Twelve cases of benign pleomorphic adenoma originating from minor salivary glands were clinically analized. The results are as follows:

1. Six male and six female patients, ranging in age of 22 to 93 years with an average of 51.5 years age, were seen.

2. The duration of lesions in cases in which patients were aware of a problem ranged from 3 days to 40 years. The chief complaint was swelling of affected regions.

3. The majority of tumors arose in the palate.

4. The tumors were various sizes and shapes; most cases were 20 to 30 mm in diameter, round in shape, elastic hard or soft in consistency, and well circumscribed. Entirely, the covering mucous was normal.

5. In six cases, palatal bone adjacent to tumor was slightly resorbed due to pressure of tumor growth.

6. All of these cases were histologically revealed and various pleomorphic natures were observed; that is adenomatous, tubular, cystic, myxomatous, cartilaginous, without suggestion of malignant transformation.

7. In out clinic, all cases were performed as a resection or enucleation and there were no evidence of recurrences.

The author have pathologically investigated the presence of lipofuscin in human tongue muscle of 89 autopsy cases.

The pigmented granules were stained black with the Masson-Fontana procedure, black with Sudan Black B and purple-pink with PAS staining, and marked yellow color autofluorescence was exhibited in unstained section under ultraviolet light. These reactions showed characteristics of the granules described as lipofuscin. Lipofuscin granules were revealed to be present in the tongue muscle fibers of 80.9% of the cases. Analysis between increase in quantity of the granule and increase in age showed that there was a statistically significant variation (P<0.001).

In order to obtein a medium which makes isolation of S. mutans easy and secure, Linke’s MSFA medium was modified. The following results were obteined using the modified Linke’s MSFA medium for isolation of S. mutans from dental plaque of children.

1. It found to be difficult to isolate S. mutans from dental plaques with Linke’s MSFA medium. However, it made possible to differentate colonies of S. mutans distinctly from other oral streptococci by combinating with tryptone.

2. Specified pigmental colonies of S. mutans were formed on our medium which contains yeast extract and tryptone in concentration of 5g and 15g/1000ml respectively.

3. Isolation rate of S. mutans in the modified MSFA medium was 10% and 19% higher than those obtained on the original MSFA or Gold’s medium respectively.

4. Type c was only type detect on Gold’s medium, whereas among the isolates from MSFA and modified MSFA media, a-type was 12.2% and b-type was 6.1%.

Since the modified MSFA discriminated each type without any bias, a more accurate epidemiological investigation of S. mutans can be carried out by using this method.

It has been noted that metastatic tumor to the oral region, especially to the jaws, are rare, since they have seldom been reported critical analytical studies dealing with the distribution of such lesions throughout the body. We report a case of metastatic lesion to the maxilla, and review some literatures.

A patient was 49-year-old male. The symptoms of onset were lumbago and maxillary swelling, and clinical diagnosis of maxillary tumor was made. At necropsy, there were large tumor masses of the left maxilla, bilateral adrenal and many small tumor nodules of various organs. Histological exami ation revealed relatively well differentiated adenocarcinoma originated from the adrenal cortex, and a large mass of left maxilla was metastasized. This case is the first report of metastasis to jawnbone from adrenocortical origin.