The objective of the present study was to determine whether amitriptyline (AMT) and promethazine (PMZ) could induce parasympathetic denervation supersensitivity of the mouse salivary gland and to clarify the relationship between the supersensitivity and the dosages or the administration period of the drugs. Pilocapine-induced salivation in mice was measured by a modified Richter's method. The results obtained in the present studies were summarized as follows.

1) Chronic administration of AMT or PMZ as well as that of atropine (ATR) induced pronounced parasympathetic denervation supersensitivity of the mouse salivary gland to pilocarpine-induced salivation.

2) The lowest amount required for the development of this supersensitivity was 0.008 mg/kg/da×5days for ATR, 2mg/kg/day x 7 days for AMT and 1.25mg/kg/day×7days for PMZ, respectively.

3) The range of the supersensitivity induced by the three drugs was up to almost the same degree, regardless of the differences of the dosage and the administration period.

4) The duration of the supersensitivity was dependent on the dosage or the administration period of the drugs.

5) From the present results, it is suggested that the supersensitivity can be induced by chronic administration of the extremely low dose of the blocker, and that changes in sensitivity of organs may be easily produced by weak stimulus such as pharmacological denervation.

In this paper we report on a case of foreign body embedded in mandible of 18-year-old girl. The foreign body which was removed by surgical operation was a mass of amalgam.

The prognosis of the patient is extremely favorable.

Authors reported a case of immediate reconstruction using sternocleidomastoid myocutaneous flap in resection for tongue cancer.

A 57-year-old female patient complained of tumor formation with a pain of the tongue. Biopsy revealed a well differlentiated squamous cell carcinoma. A subtotal glossectomy, a resection of the floor of the mouth and a left neck dissection were done. lmmediate reconstruction was done with a sternocleidomastoid myocutaneous flap.

This myocutaneous flap was effective to reconstruct the tongue and the floor of the mouth after a resection of tongue cancer.