Plasma levels of follicle stimulating hormone (FSH) and luteinizing hormone (LH) were measured to know the cause of decreased testosterone secretion in testis by surgical stress. The results were as follows. (1) Plasma levels of LH tended to fall on the first post-operative day, to return to near the pre-operative level on the third post-operative day and to rise on the seventh post-operative day. (2) Change in plasma FSH levels was minimal under surgical stress with no specific tendency. (3) A slight change of plasma LH levels varied according to age groups. (4) A slight change of plasma LH levels varied according to the severity of surgical stress. The conclusion drawn from these results was that a decrease in pituitary LH played a certain role in the depression of testicular testosterone secretion caused by surgical stress. Plasma levels of follicle stimulating hormone (FSH) and luteinizing hormone (LH) were measured to know the cause of decreased testosterone secretion in testis by surgical stress. The results were as follows. (1) Plasma levels of LH tended to fall on the first post-operative day, to return to near the pre-operative level on the third post-operative day and to rise on the seventh post-operative day. (2) Change in plasma FSH levels was minimal under surgical stress with no specific tendency. (3) A slight change of plasma LH levels varied according to age groups. (4) A slight change of plasma LH levels varied according to the severity of surgical stress. The conclusion drawn from these results was that a decrease in pituitary LH played a certain role in the depression of testicular testosterone secretion caused by surgical stress. Plasma levels of follicle stimulating hormone (FSH) and luteinizing hormone (LH) were measured to know the cause of decreased testosterone secretion in testis by surgical stress. The results were as follows. (1) Plasma levels of LH tended to fall on the first post-operative day, to return to near the pre-operative level on the third post-operative day and to rise on the seventh post-operative day. (2) Change in plasma FSH levels was minimal under surgical stress with no specific tendency. (3) A slight change of plasma LH levels varied according to age groups. (4) A slight change of plasma LH levels varied according to the severity of surgical stress. The conclusion drawn from these results was that a decrease in pituitary LH played a certain role in the depression of testicular testosterone secretion caused by surgical stress. Plasma levels of follicle stimulating hormone (FSH) and luteinizing hormone (LH) were measured to know the cause of decreased testosterone secretion in testis by surgical stress. The results were as follows. (1) Plasma levels of LH tended to fall on the first post-operative day, to return to near the pre-operative level on the third post-operative day and to rise on the seventh post-operative day. (2) Change in plasma FSH levels was minimal under surgical stress with no specific tendency. (3) A slight change of plasma LH levels varied according to age groups. (4) A slight change of plasma LH levels varied according to the severity of surgical stress. The conclusion drawn from these results was that a decrease in pituitary LH played a certain role in the depression of testicular testosterone secretion caused by surgical stress. Plasma levels of follicle stimulating hormone (FSH) and luteinizing hormone (LH) were measured to know the cause of decreased testosterone secretion in testis by surgical stress. The results were as follows. (1) Plasma levels of LH tended to fall on the first post-operative day, to return to near the pre-operative level on the third post-operative day and to rise on the seventh post-operative day. (2) Change in plasma FSH levels was minimal under surgical stress with no specific tendency. (3) A slight change of plasma LH levels varied according to age groups. (4) A slight change of plasma LH levels varied according to the severity of su

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This study was performed to devise a questionnaire for screening whether or not asthmatic children needed psychosomatic treatment. The questionnaire consisted of 3 main headings ; asthmatic attacks, parental attitudes and children's behavior. These 3 headings were subdivided into 56 items. Subjects were divided into the following two large groups : 1) Group A ; 51 asthmatic children, and their 45 fathers and 49 mothers. 2) Group B ; 88 healthy children, and their 75 fathers and 81 mothers. Group A was rearranged into the following 4 subgroups. i) 31 long hospitalized asthmatics (LA group) and 20 short hospitalized (SA group). ii) 13 asthmatics with frequent attacks (FA group) and 38 asthmatics without frequent attacks (n-FA group). iii) 21 asthmatics who were improved markedly by hospitalization (RIA group) and 27 improved to some extent (IA group). iv) 34 patients who got worse during their stay at home (XX group) and 17 showing no change (XN group). The results of our study. were summarized as follows ; 1) 85 per cent of asthmatics had psychological factors which appeared relevant to their asthma, and 65 per cent of their parents recognized this fact. 2) 60 per cent of pediatrists' judgement agreed with the results of our questionnaire. 3) The asthmatic children were found less sociable, more nervous and repressive, or dependent than the healthy ones. 4) The parents of asthmatics were more over-protective, rejective or anxious than the parents of healthy ones. 5) LA group had more psychological factors than group SA ; The former had more behavioral disturbances than the latter. 6) Mothers of FA group took less notice of psychological factors than their children did. 7) The impressions of the pediatrists were more similar to the results of our questionnaire about RIA group than about IA group. 8) The asthmatics who grew worse while staying at home had more psychological factors than the other group. The authors think that it is very important for physicians and parents to recognize psychological factors influencing asthma. For this purpose, our questionnaire can be very useful. This study was performed to devise a questionnaire for screening whether or not asthmatic children needed psychosomatic treatment. The questionnaire consisted of 3 main headings ; asthmatic attacks, parental attitudes and children's behavior. These 3 headings were subdivided into 56 items. Subjects were divided into the following two large groups : 1) Group A ; 51 asthmatic children, and their 45 fathers and 49 mothers. 2) Group B ; 88 healthy children, and their 75 fathers and 81 mothers. Group A was rearranged into the following 4 subgroups. i) 31 long hospitalized asthmatics (LA group) and 20 short hospitalized (SA group). ii) 13 asthmatics with frequent attacks (FA group) and 38 asthmatics without frequent attacks (n-FA group). iii) 21 asthmatics who were improved markedly by hospitalization (RIA group) and 27 improved to some extent (IA group). iv) 34 patients who got worse during their stay at home (XX group) and 17 showing no change (XN group). The results of our study. were summarized as follows ; 1) 85 per cent of asthmatics had psychological factors which appeared relevant to their asthma, and 65 per cent of their parents recognized this fact. 2) 60 per cent of pediatrists' judgement agreed with the results of our questionnaire. 3) The asthmatic children were found less sociable, more nervous and repressive, or dependent than the healthy ones. 4) The parents of asthmatics were more over-protective, rejective or anxious than the parents of healthy ones. 5) LA group had more psychological factors than group SA ; The former had more behavioral disturbances than the latter. 6) Mothers of FA group took less notice of psychological factors than their children did. 7) The impressions of the pediatrists were more similar to the results of our questionnaire about RIA group than

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The effects of various physiological factors and stress conditions on serum serotonin levels were examined in normal subjects, that is, the relationship of aging, circadian rhythm, ingestion of diet, physical exercise, sleep deprivation and alcohol ingestion to serum serotonin levels were investigated, and the following results were obtained. 1) As to age, serum serotonin levels were significantly higher in children below 10 years of age, and decreased gradually until age 30. 2) Sexual difference of serum serotonin levels was not found. 3) The circadian rhythm of serum serotonin levels were examined at 8,12,20 and 24 o'clock, but a significant rhythm was not observed. 4) The ingestion of a normal diet (960 Cal per meal) did not exert any influence upon serum serotonin levels. 5) Similarly, the ingestion of a high serotonin diet (banana) did not exert any influence. 6) After the load of physical exercise (2 hours of basketball playing), serum serotonin levels showed a slight increase, but it was not statistically significant. 7) Serum serotonin levels were determined during one-night of sleep deprivation, but there was no significant change because of it. 8) The effect of acute alcohol ingestion (oral ingestion of Japanese sake, 540-1800 ml) was determined. As a result, serum serotonin levels showed the tendency to increase 12 hours after ingestion as compared with the level before ingestion. 9) In one patient who had drunk alcohol for 18 years, an abrupt transient increase of serum serotonin level was observed when he stopped drinking. The effects of various physiological factors and stress conditions on serum serotonin levels were examined in normal subjects, that is, the relationship of aging, circadian rhythm, ingestion of diet, physical exercise, sleep deprivation and alcohol ingestion to serum serotonin levels were investigated, and the following results were obtained. 1) As to age, serum serotonin levels were significantly higher in children below 10 years of age, and decreased gradually until age 30. 2) Sexual difference of serum serotonin levels was not found. 3) The circadian rhythm of serum serotonin levels were examined at 8,12,20 and 24 o'clock, but a significant rhythm was not observed. 4) The ingestion of a normal diet (960 Cal per meal) did not exert any influence upon serum serotonin levels. 5) Similarly, the ingestion of a high serotonin diet (banana) did not exert any influence. 6) After the load of physical exercise (2 hours of basketball playing), serum serotonin levels showed a slight increase, but it was not statistically significant. 7) Serum serotonin levels were determined during one-night of sleep deprivation, but there was no significant change because of it. 8) The effect of acute alcohol ingestion (oral ingestion of Japanese sake, 540-1800 ml) was determined. As a result, serum serotonin levels showed the tendency to increase 12 hours after ingestion as compared with the level before ingestion. 9) In one patient who had drunk alcohol for 18 years, an abrupt transient increase of serum serotonin level was observed when he stopped drinking. The effects of various physiological factors and stress conditions on serum serotonin levels were examined in normal subjects, that is, the relationship of aging, circadian rhythm, ingestion of diet, physical exercise, sleep deprivation and alcohol ingestion to serum serotonin levels were investigated, and the following results were obtained. 1) As to age, serum serotonin levels were significantly higher in children below 10 years of age, and decreased gradually until age 30. 2) Sexual difference of serum serotonin levels was not found. 3) The circadian rhythm of serum serotonin levels were examined at 8,12,20 and 24 o'clock, but a significant rhythm was not observed. 4) The ingestion of a normal diet (960 Cal per meal) did not exert any influence upon serum serotonin levels. 5) Similarly, the

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Bronchial asthma is supposed to be one of the typical psychosomatic diseases. It is also said that asthmatic patients have particular neurotic tendencies or some character traits even before they suffer from asthma. In this paper, we studied their characters, neurotic tendencies and levels of anxiety through Yatabe-Guilford test (YG), Cornell Medical Index (CMI) and Manifest Anxiety Scale (MAS). Moreover, correlations were investigated among these three psychological tests. Subjects were out- and in-patients seen at the Department of Clinical Immunology, Dokkyo University, the allergy clinic of Department of Physical Therapy and Clinical Medicine, Tokyo University School of Medicine and an affiliate allergy clinic in Tokyo. Results were summarized as follows : 1) Psychological tests of normal subjects revealed 50% of D type (emotional stability, extroversion), 30% of C type (emotional stability, introversion), l0% of A type (well-balanced) according to YG, no neurotic tendency in CMI and 80% of low anxiety in MAS. 2) Asthmatic out-patients who had been well treated for long time were found to be slightly abnormal according to YG and MAS, but moderately neurotic according to CMI. 3) Psychological tests of new asthmatic patients at our department revealed that they showed much more abnormal tendencies than the above out-patient group. 4) On the comparison between asthmatic in-patients and out-patients, the in-patients showed much more unstable emotions in YG (i.e. increase in B and E types), neurotic tendencies in CMI and higher anxiety in MAS than the out-patients. Furthermore, female in-patients were found to be most problematic in all these tests. 5) A correlation was found between the degree of anxiety determined by MAS and the neurotic tendency determined by CMI. Statistics of the three clinics : N=93,r=0.63,p<0.001 Statistics of our department : N=56,r=0.51,p<0.001 6) Little correlation was detected between MAS and YG, and between CMI and YG.

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The authors have made a ten year investigation of the Yatabe-Guilford Personality Inventory. during its use in the annual pre-employment health examination of a certain company, from 1968 to 1977. The subjects were 6,619 female company employees aged from 17 to 22 years old. The results were as follows : 1) The percentage distribution of YG profile patterns of the workers has apparently changed over the ten year period. The percentage of A and B types has considerably increased and consequently the percentage of C and D types has decreased, as Fig. 1 shows. 2) The percentage distribution of YG profile patterns of the group graduated from university seemed to be significantly different from the two other groups that had left college or high school. As the results of Tables 2,3 and 4 indicate, the percentage of D type was high in the university graduates group. The percentage of B type represented in the high school leavers group was considerably higher than that of the university graduates group. 3) It is well known that there is a close relationship between the results of YG profile patterns and the Cornell Medical Index. In our study, approximately fifty percent of III and IV types of CMI have been judged as B or E type of YG, while no C type was recognized in III and IV type. 4) The YG profile patterns were converted to B type from other types in the patients suffering from dismenorrhea and other psychosomatic disorders and also in the workers chiefly complaining of pain and stiffness of the neck, shoulders and arms. 5) The conversion to B type has been noticed even in the control group to some extent, one and a half years after commencing work. 6) The average scores of D and C items of workers complaining of pain and stiffness of the neck, shoulders and arms increased significantly and G item decreased significantly, as compared with the test scores of the pre-employment health examination. 7) The average D item score of the control group also increased significantly one and a half years later.

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153 patients with the diagnosis of hyperventilation syndrome (HVS) were treated by us for the past five years and nine months. A study was carried out to investigate the role of β-receptor in the pathogenesis of HVS. The following results were obtained. (1) 15 mg of bufetolol hydrochloride known as β-blocker was administered to 24 cases who showed typical clinical manifestations by HV test, and 75 minutes after administration, HV test was performed again to evaluate clinical manifestations. The clinical manifestations of HVS were strikingly suppressed after administration of the βblocker. (2) At the same time, the change of arterial-blood PaCO_2 and pH induced by HV test was examined in 5 cases with typical HVS before and 75 minutes after administration of the βblocker. The decrease of PaC0_2 and increase of pH by HV test was confirmed in each HV test and the degree of change was almost equal in each HV test. (3) l.5 mg of hexoprenaline sulfate known as β-stimulant was administered to 13 cases who were diagnosed as HVS from past history without typical clinical manifestations of HVS by HV test. 70 minutes after administration of hexoprenaline sulfate, HV test was performed again. The clinical manifestations of HVS were surprisingly aggravated by HV test after administration of hexoprenaline sulfate. (4) On the basis of above results, it was concluded that the clinical manifestations of HVS were caused not solely by the change of arterial PaCO_2 and pH, but by the presence of the hyperfunction of the β-receptor. (5) The level of catecholamines was measured in 4 typical cases and 3 normal subjects before and after HV test to clarify whether the hyperfunction of β-receptor during HV attack was due to the hypersecretion of adrenaline or due to the increase of sensitivity of the β-receptor itself. No significant difference about adrenaline level was discovered between two groups. (6) From the above detailed information, it was concluded that the increase of sensitivity of the β-receptor was a very important factor for the pathogenesis of HVS.

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One of the important causes of bronchial asthma is hypersensitivity of bronchial tracts. and it is related to the condition of the autonomic nerve (AN). Microvibration (MV) is the machine for measuring the function of AN, and it analyzes the micro waves which are induced from the left hand thenar, and classifies them into 4 types, namely N, S, F, I, types. N type shows normal function of AN, S type shows normal function of AN, S type shows sympatheticotonia condition, F type shows vagotonia condition and I type is irregular type. Our samples were 103 normal subjects (60 males ranging in age from 25 to 71 years and 43 females ranging in age from 20 to 67 years) and 91 patients with bronchial asthma (40 males ranging in age from 18 to 57 years and 51 females in age from 16 to 78 years). The results were as follows : 1. MV pattern of normal subjects shows a high level of N type and lower levels of S, F and I type. On sitting position the level of S type goes up and the level of F type goes down. MV pattern shows no difference as to sex and age, but with the increase in ages, the level of S type goes down. 2. On rest supine position, F type is found to be at 39.6 percent, and on sitting position, S type has not found to go up in bronchial asthma. 3. The response to 0.2 ml injection of 0.1 percent epinephrine hydrochloride is lower in bronchial asthma than in normal subjects. 4. F type goes up in bronchial asthma patients who have neurotic tendencies and high score of of CAI. No relationship is found between MV pattern and SDS & YG. 5. On stress condition, the level of S type does not go up in asthmatic patients. 6. As is stated above, vagotonia and hypofunction of sympathetic nerve are found in bronchial asthma. So it is sugested that they are the causes of hyper-sensitivity of bronchial tracts.

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It has been recognized that there may be many psychological factors influencing to the onset and course of asthma in children, and it is necessary to treat them from the psychological standpoint. In clinical practice, however, it is difficult to perform a research on psychological factors, as intake interview takes too much time, and there are some problems with regard to the techniques of psychological tests. The authors tried to prepare a questionnaire for an easier approach to psychological factors influencing the asthmatic children. As the first procedure, Rorschach-test, YG test and Parent-Child relation test were conducted to the asthmatic children and Parent-Child relation test was conducted to the asthmatic children and Parent-Child relation test was conducted to their mothers. Nephritis patients and the normal children were compared as a control. As the results, the authors concluded that asthmatic children were characterized with their passivity, mental immaturity, poor activity, anxiety, lack of self support, lack of vitality and dependency. In general, the characteristics of mothers of asthmatic children included overprotection, interference and rejection toward their children. This questionnaire (in the children with bronchial asthma) is considered useful for grasping psychological factors.

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[in Japanese]

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Totally 41 patients consulted Department of Psychiatry, Kawasaki Medical School Hospital since 1974,with a chief complaint of impotence. These cases were classified according to etiological factors into honeymoon impotence (18 cases), neurosis (13 cases), aging (2 cases), mental deterioration (3 cases), and psychosis (5 cases). To 27 patients of honeymoon impotence and neurosis were given Yatabe-Guilford Personality Inventory (YG test) and to 11 of them were given MMPI. The results were compared with those of 75 normal males. According to YG test of these patients psychogenic impotence, the incidence of the average type and eccentric type was significantly higher, and that of the director type signiflcantly lower than the normal control group. According to MMPI, these impotent males indicated higher scores in all scales except for Scale 9 (Ma) than the normal control group. There were 7 patients who showed high scores more than 70. These high-score patients had more unfavorable prognosis than other patients with lower scores. Thus, it was found that the psychogenic impotent males were characterized with emotional instability.

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