Japanese Journal of Psychosomatic Medicine
Online ISSN : 2189-5996
Print ISSN : 0385-0307
ISSN-L : 0385-0307
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Volume 64, Issue 1
Displaying 1-17 of 17 articles from this issue
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Foreword
Special Issues / Considering Psychosomatic Medicine
Original Paper
  • Interaction between Leptin and Dopamine in the Food Reward System of Dopaminergic Neurons in High-fat Diet-induced Obesity
    Susumu Koyama, Yosuke Yamawaki, Keiji Yasukawa
    2024 Volume 64 Issue 1 Pages 53-59
    Published: 2024
    Released on J-STAGE: January 01, 2024
    Advance online publication: December 15, 2023
    DOIhttps://doi.org/10.15064/jjpm.2022028
    JOURNAL FREE ACCESS
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    Objectives : Our previous study revealed the presence or absence of a leptin response in the ventral tegmental area (VTA) of dopaminergic neurons and the enhancement of the excitability of these neurons via dopamine in mice fed a high-fat diet (HFD). HFD-fed mice were divided into obesity-prone (Ob-P) and obesity-resistant (Ob-R) groups. In this study, we hypothesized that the excitability of VTA dopaminergic neurons might be augmented through the action of leptin/dopamine in Ob-P mice compared to that in Ob-R mice.

    Methods : Spontaneous activity of VTA of dopaminergic neurons was extracellularly recorded in brain slices obtained from HFD-fed mice.

    Results : Leptin-responsive and non-leptin-responsive neurons were observed in HFD-fed mice. In Ob-P mice, the inhibition of spontaneous activity by quinpirole (a D2 receptor agonist) in non-leptin-responsive neurons was significantly lower than that in leptin-responsive neurons. No differences were observed in Ob-R mice.

    Discussion : HFD-induced obesity attenuates D2 receptor-mediated inhibition and increases the excitability of non-leptin-active VTA of dopaminergic neurons.

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Series / Stories of Psychosomatic Medicine—Message from Expert to Young Therapist
Series / Psychotherapy Up To Date
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