The case is a 77-year-old man who was first examined in August 1980 (at age 67).
Prostatic biopsy revealed a poorly-differentiated adenocarcinoma, and clinically, diagnosis was made as stage B. Castration and DES administration were carried out. Subsequent chemotherapy with BLM, MMC, and 5-FU led to CR.
A periodical check-up in September 1985 detected a pelvic lymphnode metastasis, which was, however, completely remitted by radiotherapy and chemotherapy.
In April 1990, local relapse was noted in the left lobe of the prostate.
Biopsy revealed a poorly-differentiated adenocarcinoma. Three courses of intravenous administration of CDDP, THP, and VP-16 caused no change.
From August 1990 on, anal submucosal injection of MTX was started. 20mg of MTX administration once a week, for consecutive 5 weeks, followed by 4-week interruption on ambulatory basis formed one couse.
The tumor was distinctly reduced following one course, disappeared (MRI) following two courses and showed only a few viable cells (biopsy) following four courses.
We consider that the present method is a hopeful new therapeutic approach.
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