There are four well-established theories and one emerging theory that try to explain how regional innovation happens. The former are (1) Traditional agglomeration theory, (2) Networked and embedded production theory, (3) New competition and trade theory, and (4) Knowledge economy theory. The latter is regional knowledge creation theory. In this paper we revisit and evaluate the four well-established theories and indicate some theoretical shortcomings. To overcome these limitations, we review an emerging regional knowledge creation theory, and build an integrated and multidimensional epistemological framework based on this new view. The objectives of this work were three: first, to revisit the previous innovation theories, indicate their limitations, and abstract the important factors from them; second, to review an emerging theory: regional knowledge creation theory; third, to build a multidimensional epistemological framework of regional innovation to overcome the theoretical shortcomings by synthesizing knowledge creation theory and the previous regional innovation theories. We conclude that the epistemological framework could contribute to a better understanding of regional innovation strategies, the more effective implementation of regional innovation initiatives, and the advancement of knowledge science.
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