ぴつゆいとりんハ之ヲ動物ニ注射スレバ過血糖ヲ惹起スルモノナルガ又一方ニハゑーてる並ビニあどれなりん過血糖ノ際之ヲ多少制止スル作用アリ從テいんすゆりん低血糖ニ對シ之ヲ制止スルヤ或ハ催進スルヤヲ決定スルハ頗ル面白キ問題ナリトス然ルニ從來諸家ノ研究成績ハ一致セズBurnノ如キハぴつゆいとりんハいんすゆりん低血糖ヲ制止スル作用アルモ之ヲ催進スル力ナシト云ヒOharaハ之ニ反シテぴつゆいとりんハいんすゆりん作用ニ際シテ其血糖上昇作用ニヨリ之ヲ制止スル力ナシト云ヘリ
本問題ハ尚ホ未決ニ屬スルヲ以テ余等ハ白鼠ヲ用ヰ此關係ヲ研究シ下ノ結果ヲ得タリ
(1)正常白鼠體重10gms.ニツキParke Davisぴつゆいとりん0.00001-0.0001c.c.ヲ注射スレバ確實ニ過血糖ヲ招來ス豫メ副腎ノ全剔出ヲ行ヘルモノニアリテハ此作用ヲ缺除ス故ニぴつゆりとりんハ副腎ノあどんなりん分泌ヲ催進シ得ル場合ニノミ過血糖ヲ招來シウルモノノ如シ
(2)いんすゆりん作用ニ對スルぴつゆいとりんノ効果ハ兩者ノ注射順序及ビ間隔ニヨリ著シク差異アルモノニシテ其如何ニヨリ或ハ制止作用顯ハレ或ハいんすゆりん症状ヲ催進スルモノト考フルヲ妥當トス即チいんすゆりん注射前又ハ同時ニぴつゆいとりんヲ與フレバ制止的ニ作用スルモいんすゆりん後ニ注射スルトキハ其遲キ程血糖下降ヲ制止スル力ナク又症状ヲ惡化セシムル傾向アリ例バこーま期ニ注射スルトキハ容易ニ痙攣ヲ惹起スルモノトス蓋シ100-150gms.ノ白鼠ハいんすゆりんノミニヨリテ室温ニ於テ容易ニいんすゆりん痙攣ヲ惹起セザルヲ常トス
(3)ぴつゆいとりんハ痙攣誘發作用ヲ有スルモノヽ如ク嘗ツテOlmstead & Loganガ斷頭セル猫ニ於テハいんゆすりん注射ニヨリ正常猫ノ痙攣ヲ起スニ足ル低血糖以下ニ於テモ決シテ痙攣ヲ發スルコトナシト報ゼル事實ト面白キ關係ヲ有スルモノト云フベシ

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It is well known that some bacteria, as Shiga's dysentery bacillus, Fraenkel's pneumococcus and bacillus of the rabbit pneumonia, posses the heterogeneous antigenic property.
I have also proved that a strain of Bac. bovisepticus and one out of 3 strains of Bac. lepisepticus, which isolated from rabbit septicaemia by me, have the same property.
The following is the conclusion of my study.
1) Both Bac. bovisepticus anc Bac. lepisepticus were proved to have a property to unite with a known heterogeneous antibody contained in a rabbit immune-serum against guinea-pig kidney.
2) Both of the bacilli produced anti-sheep haemolysin, when injected into rabbit.
3) The haemolysin was capable of haemolyzing the red corpuscles of sheep and goat, but not those of man, cow, horse, dog, swine, rabbit, guinea-pig, rat, mouse and frog.
4) The haemolysin was absorbed by a watery suspension or alcoholic extract of guinea-pig kidney.
5) The anti-bovisepticus and anti-lepisepticus serum from the immunized rabbits showed complemement fixation and precipitin reaction with the alcoholic extract of guinea-pig kidney,
6) The heterogeneous antibodies in the anti-bovisepticus and anti-lepisepticus serum were proved to be quite different from the specific antibodies, agglutinin, precipitin and complement fixing substance, which were also demonstrated in the serum.
7) Each of the rabbit serum immunized against guinea-pig kidney, sheep's red corpuscles, Bac. bovisepticus and Bac. lepisepticus respectively was proved to have a toxicity for guinea-pig. No parallelism was shown between the haemolytic titer and the toxicity.
8) The reaction of complement fixation and precipitation with the above sera, whereby an alcoholic extract of guinea-pig kidney being used as antigen, was not found to be parallel in degree to its toxicity for guinea-pig in a strict sense.

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臺灣ハ日本ニ於ケル養豚地ノ一ナリ總督府ハ之レガ爲メ養豚ノ保護奬勵,種類ノ改良向上及疾病ニ對スル防衞ニ大ニ努力シツツアリ從來幼豚ニ白便又ハ白痢ト稱セラルル一種ノ疾病アリテ島内各地ニ散蔓シ發生ニ弛張アルモ不斷存在スル處區々ニシテ殊ニ近年ばーくしあー種ヲ輸入シテ改良ヲ奬勵普及セントスルニ及ビ頻發シ其損害甚ダ侮ルベカラザルニ至レリ
著者ハ本病ヲ研究シ其病原ハ小腸ニ寄生スルStrongyloides suis(? Lutz 1885)ナルコトヲ知レリ此種ノ圓蟲ハ從來臺灣ニ存在セシモ豚寄生蟲檢索者ハ多クノ場合皆屠場ニ於ケル成熟豚ノ内臟ノミニ就キ材料ヲ蒐集セルヲ以テ今日迄臺灣寄生蟲目録ニハ登ラザリシナリ内地ヨリ年々多數ニ移入スルばーくしあー種豚ニ就キ檢診スルニ内地ニモ本蟲ハ可ナリ常在スルコトヲ知レリ本屬ニ入ルベキ圓蟲各種ノ形態又生態ニ關スル文献尠カラザルヲ以テ著者ハ之レヲ反覆セズ唯既往八十有餘ノ剖檢組織學的研究,二百數十回ノ幼豚糞便檢査,島内各地ノ發生状況及本蟲ノ發病性ニ鑑ミ本蟲ハ臺灣ニ廣ク存在シ潜伏慢性的ニシテ其損害ハ(1)本寄生蟲ニ因スル直接病害(2)本蟲寄生中ニ他ノ病原體ノ侵入ニ因ル間接損害ナルコトヲ知レリ

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The trypanosome employed for the present experiment, in all probability identical with T. evansi, is the strain isolated from a water-buffalo in Formosa. The animals, such as cattle, horses and rabbits, were inoculated with this trypanosome and their sera were examined weekly after isoculation for a long period by the Wassermann (Browning) and Sachs-Georgi tests. The results of both syphilis reactions obtained in these experimentally infected animals are summarized as follows:
1) Of 8 typically infected Korean calves, all showed uniformly a strikingly positive reaction in the Wassermann complement-fixation and Sachs-Georgi flocculation tests. The vacillation of reaction was noted in all cases and ran almost parallel in both tests (Tables I-IV).
2) The Wassermann reaction in the infected cattle occurs generally some 10 weeks after inoculation. The positive reaction so developed, however, continues for some period and disappears. If the patient takes a delayed course, such a positive attack is repeated at irregular intervals. In the positive reaction extended for a long duration, there is also observed a number of oscillations in the complement-fixing power.
3) The Sachs-Georgi reaction, as compared with the Wassermann, appears far earlier and turns positive, in general 1 week after inoculation. The duration of positive reaction here is decidedly longer than that of complement-fixation. In the positive Sachs-Georgi reaction when long continued, the fluctuation is also noted to certain degree, though not so distinctly as in case of the Wassermann.
4) Two Korean calves in the suspected latent infection yielded a slight and unsteady positive effect in the complement-fixation test, while they exhibited a continued positive reaction in the flocculation test (Nos. 5 and 6, Table III). Such a dissociation of 2 reactions, therefore, may probably ascertain that the tested cattle contracts a latent infection with the trypanosome.
5) If it is to diagnose the trypanosomal infection of cattle by either of the 2 syphilis tests, we prefer the Sachs-Georgi test rather to the Wassermann, on account of the reasons mentioned above. However, the systematically repeated studies of the reaction only permit us to trace the bovine trypanosomiasis in all cases.
6) The serum from normal cattle frequently showed the presence of reacting substances in the Wassermann test (13 in 50), but it is exceptional in the Sachs-Georgi test (1 in 50) (Tables V). The case reacted negatively in 2 tests may later exhibit a temporary positive turn, when the test is repeatedly carried on (Table VI).
7) In general the reaction of normal sera develops slightly and disappears after 1 or 2 weeks. This feature contrasts markedly with the high degree of complement-fixation and the long duration of flocculation elicited with sera from cases of active trypanosomiasis.
8) Contrary to the case of infected cattle, out of 9 Korean ponies infected with T. evansi, 4 seemed to react negatively and 3 weakly (Tables VII anp VIII), while one of the remaining 2 gave a strongly positive result in both reactions and the other in the flocculation only (Table IX).
9) A Korean pony inoculated with T. equiperdum reacted slightly in both tests (Table X).
10) One of 5 normal ponies, each being tested 2-7 times, showed a weakly positive effect once in respective syphilitic reactions (Table X).
11) Of 10 trypanosome-infected rabbits, 7 brought a decidedly positive result in both reactions, the other 3 reacting weakly. The 2 reactions both turn positive in about 3 weeks after inoculation and fluctuate nearly parallel with sera from the same individual (Table XI).
12) The serum from normal rabbits frequently reacts positively in one or both of 2 tests.

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