In rovariotomized adult newts,
Triturus pyrrhogaster, were given intraperitoneal injections of estriol, DES, estrone, testosterone or DCA, singly or in combination with progesterone, and the activity of alkaline phosphatase in the epithelial cells of the oviducts was studied histochemically. After injections of progesterone, estriol, estrone, testosterone or DCA for a prolonged period, the cytoplasm of the epithelial cells of the oviducts exhibited a strong or moderate reaction of alkaline phosphatase in a majority of cases, while following injections of DES, the cells showed only a weak reaction of the enzyme. Under the conditions of the present experiments, estriol, DES and estrone attenuated the enzyme-activating faculty of progesterone, while testosterone and DCA were without effect in this respect. The findings were discussed in relation to the effects of progesterone and other steroids on the ovulation in amphibians.
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